33815-55-3

Upstream product

• 79-55-0 1,2,2,6,6-pentamethylpiperidine 
• 960505-49-1 (E)-2-(3-phenylprop-2-enoyl)phenyl nonafluorobutanesulfonate 
• 673-32-5 1-Phenylprop-1-yne 
• 774-48-1 (diethoxymethyl)benzene 
• 100-52-7 benzaldehyde 
• 859314-73-1 ethyl-(1-phenyl-propenyl)-ether 
• 14182-01-5 (2E)-2-methyl-1,3-diphenylprop-2-en-1-one 
• 10242-40-7 1,1-diethoxy-1-phenylpropane 
• 93-55-0 1-phenyl-propan-1-one 
• 13304-52-4 2-methyl-3-phenylinden-1-one 
• 33815-55-3 (2R,3R)-2-methyl-3-phenyl-2,3-dihydro-1H-inden-1-one 
• 1125-88-8 benzaldehyde dimethyl acetal 

Downstream Products

• 33815-55-3 (2S,3R)-2-methyl-3-phenyl-2,3-dihydro-1H-inden-1-one 
• 75032-38-1 1-allyl-2-methyl-3-phenylindene 
• 62907-54-4 1-phenyl-2-methyl-3-allylindene 
• 75032-47-2 cis-1-allyl-2-methyl-3-phenyl-1-indanol 
• 75032-40-5 1-phenyl-2-methyl-3-(4-butenyl)indene 
• 75032-41-6 1-(4-butenyl)-2-methyl-3-phenylindene 

Relevant academic research and scientific papers

Cobalt-Catalyzed Enantio- and Diastereoselective Intramolecular Hydroacylation of Trisubstituted Alkenes

Enantio- and diastereoselective synthesis of trans-2,3-disubstituted indanones is achieved by intramolecular hydroacylation of 2-alkenylbenzaldehydes bearing trisubstituted alkenyl groups under cobalt-chiral diphosphine catalysis. Notably, a high level of enantioselectivity is induced regardless of the stereochemistry (E/Z ratio) of the alkenyl group of the starting material. Deuterium-labeling experiments shed light on the productive reaction pathways of the E- and Z-isomers.

Palladium-catalyzed asymmetric reductive Heck reaction of aryl halides

Asymmetric reductive Heck reaction of aryl halides is realized in high stereoselectivity. Hydrogen-bond donors, trialkylammonium salts in a glycol solvent, were used to promote halide dissociation from neutral arylpalladium complexes to access cationic, stereoselective pathways.

In(III)/PhCO2H binary acid catalyzed tandem [2 + 2] cycloaddition and nazarov reaction between alkynes and acetals

A facile tandem [2 + 2] cycloaddition and Nazarov reaction has been developed. The combination of In(OTf)3 and benzoic acid was found to synergistically promote the coupling of alkynes and acetals to form 2,3-disubstituted indanones in excellent yield and diastereoselectivity.

Novel one-pot approach to synthesis of indanones Through Sb(V)-catalyzed reaction of phenylalkynes with aldehydes

Catalytic SbF5 and the use of EtOH as an additive efficiently converted a mixture of phenylalkynes and aldehydes to indanone compounds in one pot, and the reaction stereoselectively afforded the corresponding 2,3-disubstituted indanones as a single trans-isomer.

Synthesis of chiral 3-substituted indanones via an enantioselective reductive-heck reaction

(Chemical Equation Presented) An efficient intramolecular palladium-catalyzed, asymmetric reductive-Heck reaction has been developed, which allowed for the synthesis of either enantiomerically enriched 3-substituted indanones or α-exo-methylene indanones depending on the base used.