33829-87-7

Usage

Uses

Used in Pharmaceutical Research:
(4-CHLORO-PHENYL)-FURAN-2-YLMETHYL-AMINE is used as a potential candidate for drug development in pharmaceutical research for its ability to be a part of new therapeutic agents. Its chemical structure, which includes both a furan ring and an amine group, makes it a subject of interest for further studies and potential applications in treating various conditions.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, (4-CHLORO-PHENYL)-FURAN-2-YLMETHYL-AMINE is used as a building block or a starting material for the synthesis of more complex molecules with potential medicinal properties. Its unique combination of functional groups allows for the creation of diverse chemical entities that can be optimized for specific biological targets.

Upstream product

• 98-01-1 furfural 
• 100-00-5 4-chlorobenzonitrile 
• 106-47-8 4-chloro-aniline 
• 617-89-0 furan-2-ylmethanamine 
• 98-00-0 (2-furyl)methyl alcohol 
• 13533-22-7 N-(2-furylmethylene)-p-chloraniline 

Downstream Products

• 95124-31-5 1-(4-Chloro-phenyl)-1-furan-2-ylmethyl-3-phenyl-thiourea 
• 95848-41-2 2-(4-chloro-phenyl)-1,2,3,6,7,7a-hexahydro-3a,6-epioxido-isoindole 

Relevant academic research and scientific papers

Furfural and 5-(hydroxymethyl)furfural valorization using homogeneous Ni(0) and Ni(II) catalysts by transfer hydrogenation

The complex [dippeNi(COD)] (dippe =1,2-bis(diisopropyl phosphino)ethane) was used as a catalytic precursor in furfural (FF) and 5-(hydroxymethyl)furfural (HMF) valorization, along with formic acid as hydrogen transfer agent, to produce the corresponding a

A Domino Aza-Piancatelli Rearrangement/Intramolecular Diels-Alder Reaction: Stereoselective Synthesis of Octahydro-1 H-cyclopenta[ cd]isoindole

For the first time, an efficient one-pot method for the construction of an angularly fused 5-6-5 aza-tricyclic framework has been developed in a highly stereoselective manner. This domino reaction is a novel combination of aza-Piancatelli rearrangement an

One-pot solvothermal synthesized CoS2@MoS2 nanocomposites for selective reduction coupling reaction to synthesize imines

Selective reduction coupling of nitroaromatics and aldehydes for imines synthesis has been investigated by using a series of bifunctional CoS2@MoS2 catalysts prepared by one-pot solvothermal method. Under optimal Co/Mo ratio of 0.75 and preparation temperature (180 °C), CoS2@MoS2–180-0.75 catalyst shows 96.5% nitrobenzene conversion, 93.0% imine selectivity and good versatility for substituted nitrobenzene and different aldehydes under mild conditions (60 °C, 1.5 MPa H2). The characterizations reveal that high nitroaromatics hydrogenation activity and good selectivity are mainly due to the formation of CoMoS phase, the coupling reaction between aniline derivatives and aldehydes is achieved by the appropriate acidity of CoS2@MoS2 nanocomposites.

Unsymmetrical indazolyl-pyridinyl-triazole ligand-promoted highly active iridium complexes supported on hydrotalcite and its catalytic application in water

Herein, an indazolyl-pyridinyl-triazole ligand was synthesized and its iridium complex supported on hydrotalcite was characterized via X-ray power diffraction (XRD), X-ray photoelectron spectroscopy (XPS), energy dispersive X-ray (EDX) spectroscopy and transmission electron microscopy (TEM). This new heterogeneous catalyst bearing the unsymmetrical indazolyl-pyridinyl-triazole ligand exhibits high catalytic activity in water. Both functionalized amines and imines were obtained from the challenging selective reaction of benzylamines with arylamines through transfer hydrogenation and dehydrogenation under clean conditions. In particular, it was observed that this catalyst system showed good recovery performance in water. Mechanistic studies showed that this transformation occurs via amine dehydrogenation, hydrolysis and condensation processes. The direct capture of the reaction intermediate provides sufficient proof for this process.

Copper N-Heterocyclic Carbene: A Catalyst for Aerobic Oxidation or Reduction Reactions

Copper N-heterocyclic carbene complexes can be readily used as catalysts for both aerobic oxidation of alcohols to aldehydes and reduction of imines to amines. Our methodology is universal for aromatic substrates and shows versatile tolerance to potential cascade reactions. A one-pot tandem synthetic strategy could afford useful imines and secondary amines via an oxidation-reduction strategy.

Structure-activity relationship study of homoallylamines and related derivatives acting as antifungal agents

The synthesis, in vitro evaluation, and structure-activity relationship studies of homoallylamines and related derivatives acting as antifungal agents are reported. Among them, compounds N-(4-bromophenyl)-N-(2-furylmethyl)amine and N-(4-chlorophenyl)-N-(2

STUDIES IN THE FURAN SERIES. 22. N-ARYLFURFURYL- AND N-ARYL-5-METHYLFURFURYLAMINES AND THEIR N-ALLYL DERIVATIVES.

The compounds, where aryl is a meta- or para-substituted chlorophenyl, methoxyphenyl, or methylphenyl group, were prepared by reduction of corresponding azomethines. Their allylation with allyl iodide or allyl bromide yielded tertiary N-arylfurfurylamines