33931-48-5

Basic information

• Product Name: Formamide, N-cyclohexyl-N-methyl-
• Synonyms: Formamide,N-cyclohexyl-N-methyl;N-cyclohexyl-N-methyl-formamide;N-Cyclohexyl-N-methyl-formamid;N-cyclohexylpiperidine-1-carboxaldehyde
• CAS NO: 33931-48-5
• Molecular Formula: C8H15NO
• Molecular Weight: 141.213
• Mol File: 33931-48-5.mol
• Article Data: 13

Chemical Properties

• Boiling Point: 250 °C
• Density: 0.96±0.1 g/cm3(Predicted)
• CAS DataBase Reference: Formamide, N-cyclohexyl-N-methyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Formamide, N-cyclohexyl-N-methyl-(33931-48-5)
• EPA Substance Registry System: Formamide, N-cyclohexyl-N-methyl-(33931-48-5)

Safety Data

• Hazardous Substances Data: 33931-48-5(Hazardous Substances Data)

Upstream product

• 100-60-7 N-methylcyclohexylamine 
• 124-38-9 carbon dioxide 
• 123-39-7 N-Methylformamide 
• 108-94-1 cyclohexanone 
• 98-94-2 N,N-dimethyl-cyclohexanamine 
• 64678-87-1 N-methyl-N-((trimethylsilyl)methyl)cyclohexanamine 
• 85462-16-4 N-Methyl-O-p-nitrophenylsulphonylhydroxylamine 
• 2043-61-0 cyclohexanecarbaldehyde 
• 64-18-6 formic acid 

Relevant articles and documents

Method for preparing formamide compound by using MCOF to catalyze CO2 as carbon source at normal temperature and pressure

The invention provides a method for preparing a formamide compound by using MCOF to catalyze CO2 as a carbon source at normal temperature and pressure, and belongs to the technical field of chemistry and chemical engineering. Under the conditions of normal temperature and normal pressure, CO2 is used as a carbon source to realize N-formylation reaction of various amine substrates. The method has the advantages that the reaction system uses the metal ion-doped two-dimensional covalent organic framework MCOF as the catalyst, CO2 is reduced at normal temperature and normal pressure to provide acyl, high-pressure hydrogen and toxic CO are prevented from being used, and the reaction conditions are mild (normal temperature and normal pressure). According to the method for preparing the formamide, the greenhouse gas carbon dioxide serves as a carbon source, the cost is low, operation is easy, reaction conditions are mild (normal temperature and normal pressure), the yield of the prepared formamide product is excellent (99%), and a green synthesis method is provided for N-acylation reaction.

Eco-friendly acetylcholine-carboxylate bio-ionic liquids for controllable: N-methylation and N-formylation using ambient CO2 at low temperatures

Catalytic fixation of CO2 to produce valuable fine chemicals is of great significance to develop a green and sustainable circulation of excessive carbon in the environment. Herein, a series of non-toxic, biodegradable and recyclable acetylcholine-carboxylate bio-ionic liquids with different cations and anions were simply synthesized for producing formamides and methylamines using atmospheric CO2 as a carbon source, and phenylsilane as a hydrogen donor. The selectivity toward products was tuned by altering the reaction temperature under solvent or solvent-free conditions. N-Methylamines (ca. 96% yield) were obtained in acetonitrile at 50 °C, while N-formamides (ca. 99% yield) were attained without a solvent at 30 °C. The established bio-ionic liquid catalytic system found a wide range of applicability in substrates and possessed a high potentiality in scale-up to gram-grade production. The developed catalytic system was fairly stable, which could be easily reused without an apparent loss of reactivity, possibly due to the strong electrostatic interactions between the cation and anion. The combination of experimental and computational results explicitly elucidated the reaction mechanism: PhSiH3 activated by a bio-IL was favorable for the formation of silyl formate from hydrosilylation of CO2, followed by a reaction with an amine to give an N-formamide, while an N-methylamine was formed by further hydrosilylation of the N-formamide.

Catalyst-free: N -formylation of amines using BH3NH3 and CO2 under mild conditions

The catalyst-free N-formylation of amines using CO2 as the C1 source and BH3NH3 as the reductant has been developed for the first time. The corresponding formylated products of both primary and secondary amines are obtained in good to excellent yields (up to 96% of isolated yield) under mild conditions.