33950-46-8

Usage

Uses

Used in Pharmaceutical Industry:
2,2-DIMETHYL-1-PHENYL-1,3-PROPANEDIOL, 9 7% is used as a chiral building block for the synthesis of chiral drugs and fine chemicals. Its unique structure allows for the creation of enantiomerically pure compounds, which are essential in the development of effective and safe medications.
Used in Polymer Industry:
In the polymer industry, 2,2-DIMETHYL-1-PHENYL-1,3-PROPANEDIOL, 9 7% is utilized as an intermediate in the production of polymers with specific properties. Its chiral nature contributes to the development of polymers with tailored characteristics for various applications.
Used in Fragrance and Flavor Industry:
2,2-DIMETHYL-1-PHENYL-1,3-PROPANEDIOL, 9 7% is employed as a key component in the synthesis of fragrances and flavors. Its ability to create chiral compounds enables the production of unique and complex scents and tastes for various consumer products.
Used in Specialty Chemicals Production:
This versatile chemical is also used in the production of specialty chemicals, where its chiral properties and reactivity contribute to the development of high-quality and innovative products for diverse applications.

InChI:InChI=1/C11H16O2/c1-11(2,8-12)10(13)9-6-4-3-5-7-9/h3-7,10,12-13H,8H2,1-2H3

Upstream product

• 597-31-9 2,2-dimethyl-3-hydroxypropionaldehyde 
• 100-52-7 benzaldehyde 
• 78-84-2 isobutyraldehyde 
• 50-00-0 formaldehyd 
• 611-70-1 phenyl isopropyl ketone 
• 1750-74-9 2-benzoyl-2-methylpropanal 
• 6651-34-9 2-methyl-1-(trimethylsilyloxy)-1-propene 
• 598-26-5 dimethylketene 
• 25491-42-3 ethyl 2,2-dimethyl-3-oxo-3-phenylpropionate 
• 52178-65-1 ethyl 3-hydroxy-2,2-dimethyl-3-phenylpropanoate 

Downstream Products

• 121108-77-8 5,5-dimethyl-4-phenyl-1,3-dioxane 
• 768-49-0 (2-methyl-1-propenyl)-benzene 
• 611-70-1 phenyl isopropyl ketone 
• 101499-58-5 1,3-diacetoxy-2,2-dimethyl-1-phenyl-propane 
• 100612-73-5 3-acetoxy-2,2-dimethyl-1-phenyl-propan-1-one 
• 24632-19-7 3,3-dimethyl-2-phenyloxetane 
• 98675-02-6 2-chloro-5,5-dimethyl-4-phenyl-1,3,2-dioxaphosphorinane 2-oxide 
• 167031-87-0 3-methanesulfonyloxy-2,2-dimethyl-1-phenyl-1-propanol 
• 64-19-7 acetic acid 
• 65-85-0 benzoic acid 
• 515174-36-4 racemic 2H-2-oxo-5,5-dimethyl-4-phenyl-1,3,2-dioxaphosphorinane 
• 170640-34-3 2-chloro-5,5-dimethyl-4-phenyl-[1,3,2]dioxaphosphinane 2-sulfide 

Relevant academic research and scientific papers

Phosphinous Acid Platinum Complex as Robust Catalyst for Oxidation: Comparison with Palladium and Mechanistic Investigations

Secondary phosphine oxides proved to be effective preligands to stabilise a hydroxy-platinum based catalyst that allows the aerobic/anaerobic oxidation of challenging substrates. Kinetic comparisons showed that this system is more efficient and stable than previously reported similar palladium-based catalysts. A neutral platinum dimer bearing bridging hydroxy ligands has been isolated and fully characterised by X-ray diffraction and its involvement in the mechanism has been evidenced by mechanistic studies.

Exploiting Carbonyl Groups to Control Intermolecular Rhodium-Catalyzed Alkene and Alkyne Hydroacylation

Readily available β-carbonyl-substituted aldehydes are shown to be exceptional substrates for Rh-catalyzed intermolecular alkene and alkyne hydroacylation reactions. By using cationic rhodium catalysts incorporating bisphosphine ligands, efficient and selective reactions are achieved for β-amido, β-ester, and β-keto aldehyde substrates, providing a range of synthetically useful 1,3-dicarbonyl products in excellent yields. A correspondingly broad selection of alkenes and alkynes can be employed. For alkyne substrates, the use of a catalyst incorporating the Ampaphos ligand triggers a regioselectivity switch, allowing both linear and branched isomers to be prepared with high selectivity in an efficient manner. Structural data, confirming aldehyde chelation, and a proposed mechanism are provided.

Optical enrichment in enzyme-catalyzed resolution of 1-aryl-2,2-dimethyl-1,3-propanediols

Novozym 435 efficiently catalyzed the chemo-, regio-, and enantioselective transesterification of 1-aryl-2,2-dimethyl-1,3-propanediols in different organic solvents with vinyl acetate as the acetyl donor at room temperature. This enzyme-catalyzed chemical

Hindered Bronsted bases as Lewis base catalysts

KHMDS and KOtBu are well established as strong, hindered, non-nucleophilic Bronsted bases. However, in the present work these bases are applied as highly active Lewis base catalysts for the formal [2+2] cycloaddition of ketenes with aldehydes and imines.

Synthesis and biological activity of a-hydroxyphosphonates

Ten α-hydroxyphosphates were synthesized and the preliminary bioessay indicated that these compounds exhibited certain herbicidal activities. Copyright Taylor & Francis Group, LLC.

A novel synthesis of 2,5-disubstituted 1,3,4-oxadiazolines by the regioselective cyclization of 1,4-disubstituted thiosemicarbazides

A novel and efficient route for the regioselective synthesis of 5-aryl-2-[(4-aryl-2-oxo-1,3,2-dioxaphosphinan-2-yl)imino]-2,3-dihydro-1,3, 4-oxadiazoles in high yield and purity by the desulfurization and cyclization of 1-benzoyl-4-[(4-aryl-2-oxo-1,3,2-di

Asymmetric cyclic phosphorothonamides containing substituted pyridine

In order to find high-acitivity and low-toxicity pesticidal lead compounds, a type of novel, asymmetric cyclic phosphorothonamides containing substituted pyridine were synthesized via the condensation reactions of 2-chloro-4- substitutedphenyl-5,5-dimethy

Phosphorus-derived chiral auxiliaries for α-alkylation of secondary amines by anodic oxidation

Chiral phosphorus-based structures were investigated as N-activating groups for anodic oxidation and as chiral inductors. This first study presents the results obtained for pyrrolidine, with allyltrimethylsilane as a standard nucleophile. The methoxylated

Lithium acetate-catalyzed crossed aldol reaction between aldehydes and trimethylsilyl enolates generated from other aldehydes

Crossed aldol reaction between aromatic aldehydes having an electron-withdrawing group and trimethylsilyl enolates generated from several aldehydes proceeded smoothly in dry or water-containing DMF in the presence of a catalytic amount of a Lewis base such as lithium acetate or lithium benzoate. Successive reduction of the produced aldehydes with sodium borohydride (NaBH4) afforded the corresponding 1,3-diols in good to high yields in one-pot. Copyright

Synthesis and biological activity of cis 2-(6-chloropyridine-3-yl) methylamino-4-substitutedphenyl-5,5-dimethyl-1,3,2-dioxaphosphinane 2-oxides

A series of novel, asymmetric-cyclic phosphoramides containing substituted pyridine were synthesized via the condensation reactions of trans 2-chloro-4-substitutedphenyl-5, 5-dimethyl-1,3,2-dioxaphosphinane 2-oxide with 2-chloro-5-aminomethylpyridine or 3