33985-68-1

Usage

Uses

Used in Pharmaceutical Applications:
3,3'-((4-Methoxyphenyl)Methylene)bis(1H-indole) is used as a therapeutic agent for targeting the Nur77 receptor. Its activation of the receptor can potentially lead to the modulation of various cellular pathways and processes, offering potential benefits in the treatment of certain diseases and conditions.
Used in Research and Development:
In the field of research, 3,3'-((4-Methoxyphenyl)Methylene)bis(1H-indole) serves as a valuable tool for studying the role and function of the Nur77 receptor in cellular processes. By understanding the interactions between 3,3'-((4-Methoxyphenyl)Methylene)bis(1H-indole) and the receptor, researchers can gain insights into the development of novel therapeutic strategies and drug candidates targeting Nur77-related pathways.
Used in Drug Discovery:
3,3'-((4-Methoxyphenyl)Methylene)bis(1H-indole) is utilized in drug discovery efforts to identify new compounds with improved Nur77 agonist properties. By optimizing the structure and function of 3,3'-((4-Methoxyphenyl)Methylene)bis(1H-indole), researchers can develop more potent and selective Nur77 agonists, which may exhibit enhanced therapeutic effects and reduced side effects in clinical applications.

Upstream product

• 120-72-9 indole 
• 836-41-9 p-methoxybenzylidene-phenylamine 
• 123-11-5 4-methoxy-benzaldehyde 
• 1968-81-6 (E)-N-(4-methoxybenzylidene)4-methylaniline 
• 98986-86-8 (E)-N-(4-chlorophenyl)-1-(4-methoxyphenyl)methanimine 
• 1613-96-3 N-(4-methoxybenzylidene)aniline 
• 57270-82-3 5-(4-methoxy-benzylidene)-1,3-dimethyl-pyrimidine-2,4,6-trione 
• 769-42-6 1,3-dimethylbarbituric acid 
• 105-13-5 4-Methoxybenzyl alcohol 
• 5765-29-7 E-2-(4-methoxybenzylidene)cyclohexanone 
• 6275-32-7 (2E,6E)-2,6-bis(4-methoxybenzylidene)cyclohexanone 
• 2051-07-2 1,5-bis-(4-methoxyphenyl)-1,4-pentadien-3-one 
• 14674-38-5 N-(4-methoxybenzylidene)-p-toluenesulfonamide 
• 2186-92-7 p-Anisaldehyde dimethyl acetal 

Downstream Products

• 120-72-9 indole 
• 1018685-90-9 12-(4-methoxyphenyl)-6-(4-methylphenyl)-5,7-dihydroindolo[2,3-b]carbazole 
• 1018685-91-0 12-(4-methoxyphenyl)-6-phenyl-5,7-dihydroindolo[2,3-b]carbazole 
• 1016883-57-0 3-[(1H-indol-3-yl)(4-methoxy-phenyl)methylene]-3H-indole 

Relevant academic research and scientific papers

Well-Defined NNS-Mn Complex Catalyzed Selective Synthesis of C-3 Alkylated Indoles and Bisindolylmethanes Using Alcohols

Herein, we demonstrated Mn-catalyzed selective C-3 functionalization of indoles with alcohols. The developed catalyst can also furnish bis(indolyl)methanes from the same set of substrates under slightly modified reaction conditions. Mechanistic studies reveal that the C-3 functionalization of indoles is going via a borrowing hydrogen pathway. To highlight the practical utility, a diverse range of substrates including nine structurally important drug molecules are synthesized. Furthermore, we also introduced a one-pot cascade strategy for synthesizing C-3 functionalized indoles directly from 2-aminophenyl ethanol and alcohol.

Phosphine-Free Manganese(II)-Catalyst Enables Acceptorless Dehydrogenative Coupling of Alcohols with Indoles

Herein, an air-stable, molecularly defined NNN?Mn(II) pincer complex catalyzed acceptorless dehydrogenative coupling of alcohols with indoles is reported. A wide variety of symmetrical and unsymmetrical bis(indolyl)methane derivatives as well as some structurally important products such as Vibrindole A, Turbomycin B alkaloid, Antileukemic, and Anticancer agents were synthesized. Mechanistic studies illustrate the importance of the NH moiety in the complex and the crucial role of metal-ligand cooperation during catalysis. (Figure presented.).

Chickpea leaf exudates: A green Br?nsted acid type biosurfactant for bis(indole)methane and bis(pyrazolyl)methane synthesis

A clean and highly efficient protocol for green synthesis of bis(indole)methanes and bis(pyrazolyl)methanes has been successfully achieved by using a naturally sourced bio-surfactant, chickpea leaf exudates (CLE), as a Br?nsted acid-type catalyst. The rea

Preparation of G-CuO NPs and G-ZnO NPs with mallow leaves, investigation of their antibacterial behavior and synthesis of bis(indolyl)methane compounds under solvent-free microwave assisted dry milling conditions using G-CuO NPs as a catalyst

In this study, biogenic copper and zinc oxide nanoparticles (G-ZnONPs and G-CuONPs) were synthesized by the green synthesis method using Malva parviflora L. (Millow) leaf extract and the obtained nanoparticles were characterized in detail with UV-Vis, FTIR, SEM, XRD. The antibacterial properties of the synthesized nanoparticles on gram-positive and gram-negative bacteria were investigated and it was found that the nanoparticles had high antimicrobial activity in the results of the experiments. With the obtained G-CuONPs, the synthesis of bis(indolyl)methanes with the "green" one-pot synthesis using microwave was achieved quickly and with high efficiency, and the thermal behavior of the obtained products was investigated.

Application of Magnetically Recoverable Core–Shell Nanocomposite in the Synthesis of Bis(indolyl)methanes at Room Temperature

Abstract: A sulfonated polyethylene glycol-supported nano-magnetite (Fe3O4@PEG-SO3H) has been prepared, characterized, and evaluated as a magnetically recoverable core–shell nanocomposite catalyst for the synthesis of bis(

Bis-indolylation of aldehydes and ketones using silica-supported FeCl3: Molecular docking studies of bisindoles by targeting SARS-CoV-2 main protease binding sites

We report herein an operationally simple, efficient and versatile procedure for the synthesis of bis-indolylmethanes via the reaction of indoles with aldehydes or ketones in the presence of silica-supported ferric chloride under grindstone conditions. The prepared supported catalyst was characterized by SEM and EDX spectroscopy. The present protocol has several advantages such as shorter reaction time, high yield, avoidance of using harmful organic solvents during the reaction and tolerance of a wide range of functional groups. Molecular docking studies targeted toward the binding site of SARS-CoV-2 main protease (3CLpro or Mpro) enzymes were investigated with the synthesized bis-indoles. Our study revealed that some of the synthesized compounds have potentiality to inhibit the SARS-CoV-2 Mpro enzyme by interacting with key amino acid residues of the active sites via hydrophobic as well as hydrogen bonding interactions.

GO-Fe3O4-Ti(IV) as an efficient magnetic catalyst for the synthesis of bis(indolyl)methanes and benzo[a]xanthen-11-one derivatives

In this study, a new and efficient magnetic composite was synthesized based on graphene oxide (GO). Initially, GO was coated with magnetite, and then Ti(IV) was fixed on GO-Fe3O4 via a covalent graft. The magnet

Magnetically recyclable CuFe2O4 catalyst for efficient synthesis of bis(indolyl)methanes using indoles and alcohols under mild condition

Bis(3-indolyl)methanes (BIM) are highly valuable and appear in the core structure of many natural products and pharmacologically active compounds (anticancer, anti-inflammatory, antiobesity, antimetastatic, antimicrobial, etc.). Herein, we have disclosed

Ruthenium Pincer Complex Catalyzed Selective Synthesis of C-3 Alkylated Indoles and Bisindolylmethanes Directly from Indoles and Alcohols

Herein, we presented Ru-SNS complex that serves as a useful catalyst for C-3 alkylation of 1H-indoles with various aliphatic primary and secondary alcohols including cyclic alcohols as well as benzylic alcohols. The selective synthesis of bisindolylmethane derivatives is also achieved from the same set of indole and alcohol just by altering the reaction parameters. Furthermore, the sustainable synthesis of C-3 alkylated indoles directly from 2-(2-nitrophenyl)ethan-1-ol and alcohols catalysed by a Ru-complex via “borrowing hydrogen” strategy is reported. This protocol provides an atom-economical sustainable route to access structurally important compounds like arundine, vibrindole A and tryptamine based derivatives. (Figure presented.).

Heterogeneous SO3H@Fe3O4 magnetic nanocatalyst as an efficient and reusable medium for the synthesis of 3,3′-(arylmethylene)-bis-(4-hydroxycoumarin), bis-(indolyl)-methane, and 1,8-dioxo-octahydroxanthene derivatives

This work aimed to synthesize a new heterogeneous catalyst (SO3H@Fe3O4 magnetic nanoparticles) and the study of its catalytic behavior in synthesizing 3,3′-(arylmethylene)-bis-(4-hydroxycoumarin), bis-(indolyl)-methane, an