341027-26-7

Upstream product

• 589-15-1 1-bromomethyl-4-bromobenzene 
• 341027-25-6 (2R,5R)-3-(3,5-dichlorophenyl)-2-isopropyl-5-methyl-1-(2,2,2-trichloroacetyl)-imidazolidin-4-one 
• 341027-24-5 (2S,5R)-3-(3,5-dichlorophenyl)-2-isopropyl-5-methylimidazolidin-4-one 
• 302840-64-8 (2R)-2-amino-N-(3,5-dichlorophenyl)-propionamide 

Downstream Products

• 302840-67-1 (2R)-2-amino-3-(4-bromophenyl)-N-(3,5-dichlorophenyl)-2-methyl-propionamide 
• 213208-73-2 (5R)-5-(4-bromobenzyl)-3-(3,5-dichlorophenyl)-5-methyl-1H-imidazole-2,4(3H,5H)-dione 
• 835917-14-1 3-(4-bromo-phenyl)-N-(3,5-dichloro-phenyl)-2-methyl-2-(5-oxo-2-thioxo-imidazolidin-1-yl)-propionamide 
• 835917-10-7 {[2-(4-bromo-phenyl)-1-(3,5-dichloro-phenylcarbamoyl)-1-methyl-ethylcarbamoyl]-methyl}-carbamic acid tert-butyl ester 
• 835917-12-9 2-(2-amino-acetylamino)-3-(4-bromo-phenyl)-N-(3,5-dichloro-phenyl)-2-methyl-propionamide 
• 397329-89-4 phosphoric acid 5-(4-bromobenzyl)-7-(3,5-dichlorophenyl)-5-methyl-6-oxo-6,7-dihydro-5H-imidazo[1,2-a]imidazol-3-yl ester diethyl ester 
• 321656-73-9 (R)-3-(4-bromobenzyl)-1-(3,5-dichlorophenyl)-5-iodo-3-methyl-1H-imidazo[1,2-α]imidazol-2-one 
• 397329-88-3 3-(4-bromobenzyl)-1-(3,5-dichlorophenyl)-3-methyl-1,6-dehydroimidazo[1,2-a]imidazole-2,5-dione 

Relevant academic research and scientific papers

An improved synthesis of N-aryl-hydantoin LFA-1 antagonists via the enantiospecific alkylation of an isobutyraldehyde-derived imidazolidinone template

An improved and cost-effective process for the synthesis of N-aryl-hydantoin LFA-1 antagonists is described. Key transformations include the synthesis and stereospecific alkylation of the trans-isobutyraldehyde-derived template 4, and the one-pot hydrolys

A practical synthesis of LFA-1 inhibitors utilizing CuCl-promoted intramolecular cyclization of thiohydantoins

An efficient and chromatography-free approach for synthesis of a new class of LFA-1 inhibitors was developed. A copper(I) chloride-promoted intramolecular cyclization of thiohydantoins 7a-b serves as a key step to highly functionalized bicyclic guanidines