An improved synthesis of N-aryl-hydantoin LFA-1 antagonists via the enantiospecific alkylation of an isobutyraldehyde-derived imidazolidinone template

DOI: 10.1016/S0957-4166(01)00009-X

Source and publish data:

Tetrahedron Asymmetry p. 101 - 104 (2001)

Update date:2022-08-02

Topics:

Authors:

Frutos, Rogelio P.

Stehle, Sandra

Nummy, Laurence

Yee, Nathan

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Article abstract of DOI:10.1016/S0957-4166(01)00009-X

An improved and cost-effective process for the synthesis of N-aryl-hydantoin LFA-1 antagonists is described. Key transformations include the synthesis and stereospecific alkylation of the trans-isobutyraldehyde-derived template 4, and the one-pot hydrolys

Full text of DOI:10.1016/S0957-4166(01)00009-X

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