344360-08-3

Basic information

• Product Name: 2-Pentenoic acid, 5-(4-methoxyphenyl)-, ethyl ester
• CAS NO: 344360-08-3
• Molecular Formula: C14H18O3
• Molecular Weight: 234.295
• Mol File: 344360-08-3.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: 2-Pentenoic acid, 5-(4-methoxyphenyl)-, ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Pentenoic acid, 5-(4-methoxyphenyl)-, ethyl ester(344360-08-3)
• EPA Substance Registry System: 2-Pentenoic acid, 5-(4-methoxyphenyl)-, ethyl ester(344360-08-3)

Safety Data

• Hazardous Substances Data: 344360-08-3(Hazardous Substances Data)

Upstream product

• 105-13-5 4-Methoxybenzyl alcohol 
• 5406-18-8 3-(p-methoxyphenyl)-1-propanol 
• 123-11-5 4-methoxy-benzaldehyde 
• 943-89-5 (E)-3-(4-methoxyphenyl)acrylic acid 
• 20401-88-1 3-(4-methoxyphenyl)propional 
• 1099-45-2 ethyl (triphenylphosphoranylidene)acetate 
• 1929-29-9 3-(4-methoxyphenyl)propanoic acid 
• 15823-04-8 methyl 3-(4-methoxyphenyl)propionate 
• 22767-72-2 ethyl 3-(4-methoxyphenyl)propanoate 
• 24393-56-4 ethyl p-methoxycinnamate 
• 867-13-0 diethoxyphosphoryl-acetic acid ethyl ester 

Downstream Products

• 160968-45-6 (2E)-5-(4-methoxyphenyl)-2-penten-1-ol 
• 79023-06-6 5-(4-methoxyphenyl)pentanoic acid ethyl ester 
• 14374-54-0 5-(4-methoxyphenyl)pentan-1-ol 
• 7508-04-5 5-(4-methoxyphenyl)pentanoic acid 
• 127047-17-0 5-(4-methoxyphenyl)pentan-1-al 
• 104375-73-7 N-tosyl-2-(p-methoxyphenyl)piperidine 
• 905293-02-9 tert-butyl (5-(4-methoxyphenyl)pentyl)carbamate 

Relevant articles and documents

Iridium-Catalyzed Regioselective Hydroalkynylation of Internal Alkenes Directed by an Oxime

We report here an iridium-catalyzed hydroalkynylation of allylic alcohols protected by an oxime group. Catalytic alkynylation occurs exclusively at the distal position of the alkene. This method generates γ-alkynyl alcohol oximes directly from internal alkenes and terminal alkynes. The oxime group can be readily removed to afford a free alcohol, thus providing an indirect route for the catalytic hydroalkynylation of allylic alcohols.

Synthesis, in vitro and in silico evaluation of diaryl heptanones as potential 5LOX enzyme inhibitors

A new series of diaryl heptanones (12a-q) were synthesized and their structures were confirmed by its 1H, 13C NMR and Mass spectral data. These analogs were evaluated for their anti-oxidant activity and potential to inhibit 5-lipoxygenase. Compounds 12k and 12o showed potent in vitro 5-lipoxygenase enzyme inhibitory activity with IC50 values of 22.2, 21.5 μM, which are comparable to curcumin (24.4 μM). Further they also have shown significant antioxidant activity. Molecular docking studies clearly showed correlation between binding energy and potency of these compounds.

GSK-3BETA INHIBITOR

For the purpose of providing a GSK-3β inhibitor containing a 2-aminopyridine compound or a salt thereof or a prodrug thereof useful as an agent for the prophylaxis or treatment of a GSK-3β-related pathology or disease, the present invention provides a GSK-3β inhibitor containing a compound represented by the formula (IA): wherein each symbol is as defined in the specification. or a salt thereof or a prodrug thereof.