34477-52-6Relevant academic research and scientific papers
Rapid construction of imidazopyridines from ortho-haloaminopyridines
Li, Chaomin,Chen, Lily,Steinhuebel, Dietrich,Goodman, Andrew
supporting information, p. 2708 - 2712 (2016/06/09)
A practical strategy for the preparation of imidazopyridine derivatives from ortho-haloaminopyridines utilizing a two-step C-N coupling/cyclization reaction sequence has been developed. This procedure provides rapid and efficient access to many medicinally interesting imidazopyridine compounds and related imidazopyrazine/purine heterocycles.
Structure-guided design of substituted aza-benzimidazoles as potent hypoxia inducible factor-1α prolyl hydroxylase-2 inhibitors
Frohn, Mike,Viswanadhan, Vellarkad,Pickrell, Alexander J.,Golden, Jennifer E.,Muller, Kristine M.,Buerli, Roland W.,Biddlecome, Gloria,Yoder, Sean C.,Rogers, Norma,Dao, Jennifer H.,Hungate, Randall,Allen, Jennifer R.
scheme or table, p. 5023 - 5026 (2009/05/26)
We report the structure-based design and synthesis of a novel series of aza-benzimidazoles as PHD2 inhibitors. These efforts resulted in compound 22, which displayed highly potent inhibition of PHD2 function in vitro.
Synthesis and anticonvulsant activity of 1-benzyl-4-alkylamino-1H-imidazo[4,5-c]pyridines
Kelley,Linn,Rideout,Soroko
, p. 1255 - 1258 (2007/10/02)
Four 3-deaza analogues of the potent anticonvulsant purine, BW A78U, were synthesized and tested for anticonvulsant activity. The imidazo[4,5-c]pyridines 9-12 were prepared in two steps from 4-chloro-1H-imidazo[4,5-c]pyridine (2).The compounds were potent
