3450-91-7

Upstream product

• 3341-67-1 methyl 2-(1-methyl-3-benzyl-2-oxo-2,3-dihydro-1H-indol-3-yl)acetate 
• 88320-94-9 2-benzylpropenoyl chloride 
• 501-52-0 3-Phenylpropionic acid 
• 49769-78-0 2-benzyl-malonic acid dimethyl ester 
• 5669-19-2 2-Benzyl-2-propenoic acid 
• 100-39-0 benzyl bromide 
• 67-66-3 chloroform 

Downstream Products

• 1360238-49-8 (S)-3-(2-((S)-3-benzyl-1-methyl-2-oxoindolin-3-yl)-acetyl)-4-phenyloxazolidin-2-one 
• 1360238-30-7 (S)-3-(2-((R)-3-benzyl-1-methyl-2-oxoindolin-3-yl)acetyl)-4-phenyloxazolidin-2-one 

Relevant academic research and scientific papers

Palladium-Catalyzed Heck-type Domino Cyclization and Carboxylation to Synthesize Carboxylic Acids by Utilizing Chloroform as the Carbon Monoxide Source

A palladium-catalyzed domino cyclization and carboxylation reaction for synthesis of a variety of carboxylic acids was developed, where chloroform was used as "carbon monoxide" source. The in situ generated neopentylpalladium species by Heck cyclization was efficiently trapped by dichlorocarbene to form a series of carboxylic acids. It was found that in this type of domino reaction CHCl3 is a convenient and safe alternation for CO gas.

Absolute configuration determination of 2-(2-oxo-3-indolyl)acetamide derivatives

We describe a reliable method for determining the absolute configuration of 2-(2-oxo-3-indolyl)acetamides based on analysis of the 1H NMR spectra of their phenylethylamide diastereomers. The conformational preferences for two diastereomeric ami