345635-46-3

Upstream product

• 3058-47-7 methyl 2-nitrophenyl sulfide 
• 7726-95-6 bromine 
• 64-19-7 acetic acid 
• 624-92-0 Dimethyldisulphide 
• 875-51-4 4-Bromo-2-nitroaniline 
• 110-46-3 isopentyl nitrite 
• 67-68-5 dimethyl sulfoxide 
• 364-73-8 4-Bromo-1-fluoro-2-nitrobenzene 
• 5188-07-8 sodium thiomethoxide 

Downstream Products

• 14601-59-3 4-bromo-1-methanesulfonyl-2-nitro-benzene 
• 139192-88-4 2-amino-4-bromophenyl methyl sulphide 
• 63837-11-6 5-bromo-2-methylbenzothiazole 

Relevant academic research and scientific papers

Freezing the conductance of platinum(II) complexes by quantum interference effect

Understanding the impact of substituents on the quantum interference effect at single molecule scale is of great importance for the design of molecular devices. In this work, three platinum(II) complexes with –H, –NH2 and –NO2 groups on conductive backbones were designed and synthesized. Single-molecule conductance, which was measured using scanning tunnelling microscope break junction (STM-BJ) technique, demonstrated a conductance freeze phenomenon under the variation of substituents. Theoretical study revealed that, despite the electronic effect of the substituents shifting the energy level of molecular orbital, the quantum interference effect vanished the influence of electronic effect on the conductance and eventually leaded to the conductance freeze.

Visible Light-Induced Metal-Free and Oxidant-Free Radical Cyclization of (2-Isocyanoaryl)(methyl)sulfanes with Ethers

A novel cascade cyclization of (2-isocyanoaryl) (methyl)sulfanes and ethers is developed. With 4CzIPN as a photocatalyst and the irradiation of blue LED light, ether radicals are efficiently generated without adding any oxidant, endowing the strategy with features of oxidant-free, metal-free, mild reaction conditions, and operational simplicity. This strategy provides efficient approach to access various ether-containing benzothiazoles in acceptable to good yields.

Sodium Sulfite-Involved Photocatalytic Radical Cascade Cyclization of 2-Isocyanoaryl Thioethers: Access to 2-CF2/CF3-Containing Benzothiazoles

A visible-light-induced radical cascade cyclization of 2-isocyanoaryl thioethers for the synthesis of 2-CF2/CF3-containing benzothiazoles has been developed. Sodium sulfite can participate in the photocatalytic cycle as a reductant that efficiently transforms Ir4+ into Ir3+ to promote the fluoroalkylation under mild reaction conditions.

Di- tert-butyl Peroxide-Mediated Radical C(sp2/sp3)-S Bond Cleavage and Group-Transfer Cyclization

A novel strategy of cascade radical C(sp2/sp3)-S bond cleavage and group-transfer cyclization is disclosed. Triggered by alkyl radicals, varieties of 2-isocyanoaryl thioethers containing aliphatic, aryl, and heteroaromatic groups can be cleaved and precisely reinstalled to give benzothiazole derivatives. Mechanistic studies reveal that the cascade reaction undertakes an intermolecular pathway, and the inner radical sources (R radicals) exhibit high priority over those of methyl radical origin from di-tert-butyl peroxide.

Copper-catalyzed decarboxylative methylthiolation of aromatic carboxylate salts with DMSO

A novel copper-catalyzed decarboxylative methylthiolation of arenecarboxylate salts has been realized using DMSO as the methylthiolation source. Various potassium aryl carboxylates underwent decarboxylative methylthiolation under air to furnish the corresponding aryl methyl thioethers in moderate to excellent yields. The reaction tolerated a wide variety of functional groups. Notably, the synthesis of ethylthioethers was also successfully achieved directly from diethyl sulfoxide under similar reaction conditions.

Process for the preparation of N-(phenylethyl) anilines salts and solvates thereof useful as serotonin 5-HT6 antagonists

The invention relates to a process for preparing N-(1-phenylethyl)anilines, salts, and solvates thereof, to novel intermediates, and to the use of the intermediates in the preparation of serotonin 5-HT6 antagonists.

Tetrazolyl-phenyl acetamide glucokinase activators

Tetrazolyl-phenyl acetamides are active as glucokinase activators, and are able to increase insulin secretion, which makes them useful for treating type II diabetes.

Tetrazolyl-phenyl acetamide glucokinase activators

Tetrazolyl-phenyl acetamides are active as glucokinase activators, and are able to increase insulin secretion, which makes them useful for treating type II diabetes.

Trans olefinic glucokinase activators

2,3-Di-substituted trans olefinic N-heteroaromatic or urido propionamides with said substitution at the 2-position being a substituted phenyl group and at the 3-position being a cycloalkyl ring, said propionamides being glucokinase activators which increase insulin secretion in the treatment of type II diabetes.