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Thrombin inhibitors based on [5,5] trans-fused indane lactams

DOI: 10.1016/S0960-894X(99)00244-9

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 1657 - 1662 (1999)

Update date:2022-08-16

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Authors:

Pass, MartinPass, Martin

Abu-Rabie, SaidAbu-Rabie, Said

Baxter, AndrewBaxter, Andrew

Conroy, RichardConroy, Richard

Coote, Steven J.Coote, Steven J.

Craven, Andrew P.Craven, Andrew P.

Finch, HarryFinch, Harry

Hindley, SeanHindley, Sean

Kelly, Henry A.Kelly, Henry A.

Lowdon, Andrew W.Lowdon, Andrew W.

McDonald, EdwardMcDonald, Edward

Mitchell, William L.Mitchell, William L.

Pegg, Neil A.Pegg, Neil A.

Procopiou, Pan A.Procopiou, Pan A.

Ramsden, Nigel G.Ramsden, Nigel G.

Thomas, RhianThomas, Rhian

Walker, Dawn A.Walker, Dawn A.

Watson, Nigel S.Watson, Nigel S.

Jhoti, HarrenJhoti, Harren

Mooney, Christopher J.Mooney, Christopher J.

Tang, Chi-ManTang, Chi-Man

Thomas, Pamela J.Thomas, Pamela J.

Parry, SimonParry, Simon

Patel, ChampaPatel, Champa

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Article abstract of DOI:10.1016/S0960-894X(99)00244-9

A series of trans-fused lactams containing the indane nucleus has been prepared. Compound 19 has much enhanced plasma stability compared with its lactone counterpart and shows appreciable in vitro anticoagulant activity.

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Full text of DOI:10.1016/S0960-894X(99)00244-9

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