Bioorganic and Medicinal Chemistry Letters p. 1657 - 1662 (1999)
Update date:2022-08-16
Topics:
Pass, Martin
Abu-Rabie, Said
Baxter, Andrew
Conroy, Richard
Coote, Steven J.
Craven, Andrew P.
Finch, Harry
Hindley, Sean
Kelly, Henry A.
Lowdon, Andrew W.
McDonald, Edward
Mitchell, William L.
Pegg, Neil A.
Procopiou, Pan A.
Ramsden, Nigel G.
Thomas, Rhian
Walker, Dawn A.
Watson, Nigel S.
Jhoti, Harren
Mooney, Christopher J.
Tang, Chi-Man
Thomas, Pamela J.
Parry, Simon
Patel, Champa
A series of trans-fused lactams containing the indane nucleus has been prepared. Compound 19 has much enhanced plasma stability compared with its lactone counterpart and shows appreciable in vitro anticoagulant activity.
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