34877-80-0Relevant academic research and scientific papers
One-Pot Enol Silane Formation-Alkylation of Ketones with Propargyl Carboxylates Promoted by Trimethylsilyl Trifluoromethanesulfonate
Downey, C. Wade,Confair, Danielle N.,Liu, Yiqi,Heafner, Elizabeth D.
supporting information, p. 12931 - 12938 (2018/10/20)
Ketones readily undergo conversion to enol silanes in the presence of a trialkylamine base and trimethylsilyl trifluoromethanesulfonate (TMSOTf) and add to propargyl cations to yield β-alkynyl ketones. The propargyl cations are generated in the same react
A alkynyl ketone compound synthesis method
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Paragraph 0030; 0031; 0032; 0033, (2017/08/25)
The invention provides a synthetic method of an acetylenic ketone compound shown in a formula (III). The synthetic method comprises the following steps: a compound shown in a formula (I), a compound shown in a formula (II) and an organic solvent are added to a reaction kettle in a nitrogen atmosphere, the mixture is heated to 40-50 DEG C and stirred and mixed for 10 min, then a catalyst and an additive are added, heat is preserved and stirring is performed for reaction for 3-5 h, and the compound shown in the formula (III) shown in the specification is obtained through posttreatment after the reaction, wherein R is H, a C1-C6 alkoxy group or halogen; Ar1 and Ar2 are independently selected from an unsubstituted phenyl group, a phenyl group with a substituent, an unsubstituted thienyl group or a thienyl group with a substituent respectively, and the substituent is a C1-C6 alkyl group or a C1-C6 alkoxy group. According to the synthetic method, the yield of a product is increased effectively by the aid of the synergistic effects of three components including the catalyst, the additive and the organic solvent, an excellent technological effect is obtained, and broad industrial application prospects and production potential are realized.
Michael Addition of Soft Carbon Nucleophiles to Alkylidene Isoxazol-5-ones: A Divergent Entry to β-Branched Carbonyl Compounds
Capreti, Naylil M. R.,Jurberg, Igor D.
supporting information, p. 2490 - 2493 (2015/05/27)
A novel, divergent strategy toward the synthesis of β-branched (and linear) carbonyl compounds is developed by taking advantage of alkylidene isoxazol-5-ones as key building blocks. The yields obtained range from good to excellent, therefore making the described methods attractive options for building such molecules. (Chemical Equation).
ORGANOBORON COMPOUND AND METHOD FOR PRODUCING THE SAME
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Paragraph 0199-0200, (2016/10/08)
PROBLEM TO BE SOLVED: To provide a method for producing an organoboron compound including a carbon atom (C≡C-B) having both a triple bond with another carbon atom and a bond with a boron atom utilizing a dehydrogenative borylation reaction inexpensively and simply and to provide the novel organoboron compound. SOLUTION: The method for producing an organoboron compound makes a compound having an ethynyl group at a terminal of the molecule and a compound represented by formula (2) as given below in the coexistence of a Lewis acid react to form a bond between a carbon atom to which a hydrogen atom of the ethynyl group is bonded and a boron atom of the compound represented by formula (2). The organoboron compound is represented by formula (3) as given below. COPYRIGHT: (C)2015,JPOandINPIT
Silver hexafluoroantimonate-catalyzed direct α-alkylation of unactivated ketones
Naveen, Naganaboina,Koppolu, Srinivasa Rao,Balamurugan, Rengarajan
, p. 1463 - 1473 (2015/05/26)
A practically simple and direct α-alkylation of unactivated ketones using benzylic alcohols has been achieved. The in situ formed acetals are the key for the success of the reaction. The catalyst, silver hexafluoroantimonate(V) (AgSbF6) provide
Catalytic decarboxylative alkylation of β-keto acids with sulfonamides via the cleavage of carbon-nitrogen and carbon-carbon bonds
Yang, Cui-Feng,Wang, Jian-Yong,Tian, Shi-Kai
supporting information; experimental part, p. 8343 - 8345 (2011/09/16)
An efficient decarboxylative alkylation reaction of β-keto acids with N-benzylic or N-allylic sulfonamides has been developed, for the first time, through sequential cleavage of carbon-nitrogen and carbon-carbon bonds in the presence of 10 mol% of FeCl3.
1, 4-addition of terminal alkynes to conjugated enones in water using green catalyst bis[(l)prolinato-N,O]Zn-An environmentally benign protocol
Kidwai, Mazaahir,Jain, Arti,Bhardwaj, Saurav
experimental part, p. 183 - 190 (2011/10/05)
An easy, low cost, and green procedure is proposed for the 1, 4-addition of terminal alkynes to conjugated enones in water as a sole medium using easily accessible Zn[(l)Proline]2. This protocol has advantages of high yield, mild reaction condi
A novel indium-catalyzed three-component reaction: General and efficient one-pot synthesis of substituted pyrroles
Lin, Min,Hao, Lu,Ma, Rui-Da,Zhan, Zhuang-Ping
experimental part, p. 2345 - 2351 (2010/11/04)
A convenient and general approach towards the synthesis of substituted pyrroles from propargylic acetates, silyl enol ethers, and primary amines was described. This novel transformation was catalyzed by indium trichloride in a one-pot synthesis, and high
Rapid 1,4-alkynylation of acyclic enones using K[F3BC≡CR]
Bertolini, Ferruccio,Woodward, Simon
experimental part, p. 51 - 54 (2009/05/27)
Conjugate alkynylation of acyclic enones using sp-hybridised potassium organotrifluoroborates in the presence of BF3·OEt2 is rapidly attained. The simplicity of the processes is suitable for the preparation of small compound librarie
FeCl3-catalyzed nucleophilic substitution of propargylic acetates with enoxysilanes
Zhan, Zhuang-Ping,Cai, Xu-Bin,Wang, Shao-Pei,Yu, Jing-Liang,Liu, Hui-Juan,Cui, Yuan-Yuan
, p. 9838 - 9841 (2008/03/28)
(Chemical Equation Presented) An efficient FeCl3-catalyzed substitution reaction of propargylic acetates with enoxysilanes under mild conditions to afford corresponding γ-alkynyl ketones has been developed. The substitution reaction is followed
