34900-45-3

Usage

Molecular Weight

173.19 g/mol

Structure

A pyrrolidine-2,5-dione derivative with a phenyl substituent at the 3-position.

Applications

Versatile in organic synthesis and pharmaceutical research, studied for potential therapeutic effects in the treatment of various diseases and conditions.

Importance

A key intermediate in the synthesis of various organic compounds, used as a building block in the production of pharmaceuticals and other chemicals.

Upstream product

• 541-59-3 maleiimide 
• 100-34-5 benzene diazonium chloride 
• 7732-18-5 water 
• 67-64-1 acetone 
• 553-54-8 lithium benzoate 
• 80-17-1 benzenesufonyl hydrazide 
• 98-09-9 benzenesulfonyl chloride 
• 36122-35-7 2-phenylmaleic anhydride 
• 62-53-3 aniline 

Downstream Products

• 257865-87-5 N-(3,5-dinitrophenyl)-methyl-α-phenylmaleimide 
• 142-82-5 n-heptane 
• 940055-66-3 3-(2-aminobenzylamino)-4-phenylpyrrolidine-2,5-dione 
• 940055-65-2 3-(2-oxo-1,4-dihydro-2H-quinazolin-3-yl)-4-phenylpyrrolidine-2,5-dione 
• 114531-21-4 (S)-3-phenyl-2,5-pyrrolidinedione 
• 114531-20-3 (R)-3-phenyl-2,5-pyrrolidinedione 

Relevant academic research and scientific papers

Approach to the Synthesis of Unsymmetrical/Symmetrical Maleimides via Desulfitative Arylation at Different Temperatures

New routes toward selective synthesis of both mono-and diaryl maleimides have been innovated. The mere requirement to this end is through the increase of temperature. The method works effectively for maleic anhydride and maleic acid as well. Also, the fir

Weak Coordinating Carboxylate Directed Rhodium(III)-Catalyzed C-H Activation: Switchable Decarboxylative Heck-Type and [4 + 1] Annulation Reactions with Maleimides

A weakly coordinating carboxylate directing group assisted C-H activation with maleimides leading to novel and switchable decarboxylative Heck-type and [4 + 1] annulation products catalyzed by Rh(III) has been reported. In these reactions, solvents play a

The base-catalysed Tamura cycloaddition reaction: Calculation, mechanism, isolation of intermediates and asymmetric catalysis

A combined experimental and computational investigation has revealed that the base-catalysed Tamura cycloaddition between homophthalic anhydride and activated alkenes/alkynes-a reaction previously thought of as a Diels-Alder type process-proceeds via a stepwise mechanism involving conjugate addition and ring closure; which allowed the first catalytic asymmetric α-substitution reactions to be demonstrated with up to >99% ee.

Selective and tunable synthesis of 3-arylsuccinimides and 3-arylmaleimides from arenediazonium tetrafluoroborates and maleimides

A highly efficient synthetic strategy for synthesizing 3-arylsuccinimides has been developed from arenediazonium tetrafluoroborates and maleimides in the presence of TiCl3. The reactions generated 3-arylsuccinimides in satisfactory yields under mild reaction conditions. In addition, 3-arylmaleimides were obtained by the coupling of arenediazonium tetrafluoroborate and maleimides catalyzed by CuCl. This methodology provided the selective and tunable synthesis of two classes of products by simply switching different metal reagents. The methods are simple, efficient and practical.

Pyrrolidine(thi)ones Substituted by Heterocyclic Substituents in The 3-Position

Pyrrolidine(thi)one compounds substituted by heterocyclic substituents in the 3-position, their preparation and use in pharmaceutical compositions, in particular as immunomodulators for treatment and/or inhibition of inflammatory and autoimmune diseases and haematological-oncological diseases.