350014-19-6

Basic information

• Product Name: 2-tert-butyl 1-methyl 6-hydroxy-3,4-dihydroisoquinoline-1,2(1H)-dicarboxylate
• Synonyms: 2-tert-butyl 1-methyl 6-hydroxy-3,4-dihydroisoquinoline-1,2(1H)-dicarboxylate;2-tert-butyl 1-methyl 3,4-dihydro-6-hydroxyisoquinoline-1,2(1H)-dicarboxylate
• CAS NO: 350014-19-6
• Molecular Formula: C₁₆H₂₁NO₅
• Molecular Weight: 307.34164
• Mol File: 350014-19-6.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-tert-butyl 1-methyl 6-hydroxy-3,4-dihydroisoquinoline-1,2(1H)-dicarboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: 2-tert-butyl 1-methyl 6-hydroxy-3,4-dihydroisoquinoline-1,2(1H)-dicarboxylate(350014-19-6)
• EPA Substance Registry System: 2-tert-butyl 1-methyl 6-hydroxy-3,4-dihydroisoquinoline-1,2(1H)-dicarboxylate(350014-19-6)

Safety Data

• Hazardous Substances Data: 350014-19-6(Hazardous Substances Data)

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 350014-18-5 1,2,3,4-Tetrahydro-6-hydroxy-1-isoquinolinecarboxylic acid methyl ester 
• 2039-67-0 2-(3-methoxyphenyl)-1-ethanamine 
• 38449-59-1 2-(3-hydroxyphenyl)ethylamine hydrobromide 
• 1068562-72-0 C₂₁H₂₉NO₇ 
• 91523-50-1 rac-6-hydroxy-1,2,3,4-tetrahydroisoquinoline-1-carboxylic acid 
• 588-05-6 m-tyramine 
• 77-78-1 dimethyl sulfate 
• 362492-00-0 2-(tert-butoxycarbonyl)-6-hydroxy-1,2,3,4-tetrahydroisoquinoline-1-carboxylic acid 

Downstream Products

• 531554-36-6 C₂₈H₃₉N₃O₃ 
• 373638-23-4 1-[[[(R)-2-[bis(1-methylethyl)amino]ethyl]amino]carbonyl]-3,4-dihydro-6-(phenylmethoxy)-2-(1H)-isoquinoline-carboxylic acid 1,1-dimethylethyl ester 
• 373633-80-8 1-[[[(S)-2-[bis(1-methylethyl)amino]ethyl]amino]carbonyl]-3,4-dihydro-6-(phenylmethoxy)-2-(1H)-isoquinoline-carboxylic acid 1,1-dimethylethyl ester 
• 531553-76-1 C₃₅H₃₇N₃O₃ 
• 373633-79-5 1-[[[2-[bis(1-methylethyl)amino]ethyl]amino]carbonyl]-3,4-dihydro-6-(phenylmethoxy)-2-(1H)-isoquinoline-carboxylic acid 1,1-dimethylethyl ester methanesulfonate 
• 499139-27-4 2-(tert-butoxycarbonyl)-6-methoxy-1,2,3,4-tetrahydroisoquinoline-1-carboxylic acid 
• 1447733-07-4 4-(6-methoxy-1,2,3,4-tetrahydroisoquinoline-1-carboxamido)benzoic acid trifluoracetate 
• 1430216-08-2 (E)-4-(2-(3-(5-chloro-2-(1H-tetrazol-1-yl)phenyl)acryloyl)-6-methoxy-1,2,3,4-tetrahydroisoquinoline-1-carboxamido)benzoic acid 
• 1430217-41-6 4-(6-(2-methoxyethoxy)-1,2,3,4-tetrahydroisoquinoline-1-carboxamido)benzoic acid trifluoroacetate 
• 1430216-07-1 (E)-4-(2-(3-(5-chloro-2-(1H-tetrazol-1-yl)phenyl)acryloyl)-6-(2-methoxyethoxy)-1,2,3,4-tetrahydroisoquinoline-1-carboxamido)benzoic acid 

Relevant articles and documents

Enzymatic resolution of methyl (1RS)-N-tBoc-6-hydroxy-3,4-dihydro-1H-isoquinoline-1-carboxylate by Seaprose S

An efficient biocatalytic process has been developed for the resolution of methyl (1RS)-N-tBoc-6-hydroxy-3,4-dihydro-1H-isoquinoline-1-carboxylate rac-1 by means of Seaprose S-mediated enantioselective hydrolysis to afford (1S)-2 and (1R)-1 in 87% and 93% isolated yield, 101% and 96% potency, and ee >99.8% and >99.5%, respectively.

Tetrahydroisoquinoline LXR modulators

A compound of formula I wherein X, R1, R2a, R3a, R3b, R4a, R4b, R4c and R5 are defined herein.

Tetrahydroisoquinoline 1-carboxamides as growth hormone secretagogues

Several novel series of tetrahydroisoquinoline 1-carboxamides were prepared and shown to be potent growth hormone (GH) secretagogues. Among them, carbamate 12a-E2 displays excellent in vivo activity by increasing plasma GH 10-fold in an anesthetized IV rat model.

Tetrahydroisoquinoline analogs as modulators of chemokine receptor activity

Tetrahydroisoquinoline analogs are provided which are modulators of chemokine receptor activity. The tetrahdroisoquinoline analogs thereof have the structure wherein R1, R2, R3, R3a, X1, X2, X3, X4, m, n and p are as described herein.

Lactam derivatives as antiarrhythmic agents

Lactam derivatives of the formula where X is —C(═O)NR3′—, —NR3′C(═O)—, —C(═NCN)NR3′—, —NR3′C(═NCN)—, —CH2NR3′—, —CH(alkyl)NR3′—, —CH(COOalkyl)NR3′—, —CH(CH2