35008-50-5

Usage

Uses

Used in Pharmaceutical Industry:
(PHENYLSULFONYL)ACETAMIDE is used as a building block in organic synthesis for the development of drugs with anti-inflammatory and analgesic properties. It aids in the creation of medications to treat various conditions, including pain, fever, and inflammation.
Used in Organic Chemistry:
(PHENYLSULFONYL)ACETAMIDE is used as an important intermediate in organic chemistry, facilitating the synthesis of a wide range of pharmaceutical compounds. Its versatility in organic synthesis contributes to the advancement of medicinal chemistry and drug discovery.

InChI:InChI=1/C8H9NO3S/c9-8(10)6-13(11,12)7-4-2-1-3-5-7/h1-5H,6H2,(H2,9,10)

Upstream product

• 7605-30-3 ethyl 2-phenylsulfonylacetate 
• 144-48-9 iodacetamide 
• 873-55-2 sodium benzenesulfonate 
• 7605-28-9 2-(phenylsulfonyl)acetonitrile 
• 79-07-2 Chloroacetamide 
• 64-17-5 ethanol 

Downstream Products

• 36967-95-0 benzenesulfonyl-p-tolylhydrazono-acetic acid amide 
• 36967-96-1 benzenesulfonyl-m-tolylhydrazono-acetic acid amide 
• 17025-47-7 ((tribromomethyl)sulfonyl)benzene 
• 78440-45-6 3-phenylsulfonyl-2-oxo-2H-1-benzopyran 
• 61053-60-9 2-Benzenesulfonyl-2-methanesulfonyl-acetamide 
• 96237-32-0 2-amino-6-phenyl-5-phenylsulphonylpyrimidin-4(1H)-one 
• 96237-33-1 2-amino-5-phenylsulphonyl-6-(p-tolyl)pyrimidin-4(1H)-one 
• 50709-90-5 (Z)-2-Benzenesulfonyl-3-(4-nitro-phenyl)-acrylamide 
• 50709-92-7 (Z)-2-Benzenesulfonyl-3-(4-hydroxy-phenyl)-acrylamide 
• 40235-50-5 (Z)-2-Benzenesulfonyl-3-(4-dimethylamino-phenyl)-acrylamide 
• 69563-96-8 3-Phenylsulfonyl-2,6-dichlorpyridin 
• 69564-06-3 3-benzenesulfonyl-2,4,6-trichloro-pyridine 
• 69563-98-0 3-Benzenesulfonyl-6-diethylamino-pyridin-2-ol 
• 73481-57-9 3-Benzenesulfonyl-N²,N⁶-diphenethyl-pyridine-2,6-diamine 

Relevant academic research and scientific papers

Benzenesulfonamide compounds

The present invention provides a benzenesulfonamide compound represented by chemical formula 1 or a biotinylated compound thereof. The compounds of the present invention selectively react with a sulfhydryl group (-SH) having unoxidized cysteine, and do no

Bis(allyl)ruthenium(rV) complexes containing water-soluble phosphane ligands: Synthesis, structure, and application as catalysts in the Selective hydration of organonitriles into amides

The novel mononuclear ruthenium(IV) complexes [RuCl2(η 3: η3-C10H16)(L)] [L = (meta-sulfonatophenyl)diphenylphosphane sodium salt (TPPMS) (2a), 1,3,5-triaza-7-phosphatricyclo[3.3.1.13,7]decane (PTA) (2b), 1-benzyl-3,5-diaza-1-azonia-7-phosphatricyclo[3.3.1.13,7]decane chloride (PTABn) (2c), 3,7-diacetyl-1,3,7-triaza-5-phosphabicyclo[3.3.1]nonane (DAPTA) (2d), and 2,4,10-trimethyl-1,2,4,5,7,10-hexaaza-3-phosphatricyclo[3.3.1. 13,7]decane (THPA) (2e)] have been synthesized by treatment of the dimeric precursor [{RuCl(μ-Cl)((η3: η3-C 10H16)}2] (C10H16 = 2,7-dimethylocta-2,6-diene-1,8-diyl) (1) with two equivalents of the corresponding water-soluble phosphane. Reaction of 1 with one equivalent of the cage-type diphosphane ligand 2,3,5,6,7,8-hexamethyl-2,3,5,6,7,8-hexaaza-1,4- diphosphabicyclo[2.2.2]octane (THDP) allowed also the high-yield preparation of the dinuclear derivative [[RuCl2(η3: η3-C10H16)}2(μ-THDP)] (2f). All these new complexes have been analytically and spectroscopically (IR and multinuclear NMR) characterized. In addition, the structure of 2b, 2c, 2d, and 2 f was unequivocally confirmed by X-ray diffraction methods. Complexes 2a-f are active catalysts for the selective hydration of nitriles to amides in pure aqueous medium under neutral conditions. The wide scope of this catalytic transformation has been evaluated by using the most active catalysts [RuCl 2(η3: η3-C10H 16)(THPA)] (2e) and [{RuCl2(η3: η3-C10H16)}2(μ-THDP)] (2f). Advantages of using MW versus conventional thermal heating are also discussed.

Selective ruthenium-catalyzed hydration of nitriles to amides in pure aqueous medium under neutral conditions

A study was conducted to demonstrate that water-soluble ruthenium(II) complexes can be used as catalysts for the hydration of nitriles in pure aqueous media and under neutral conditions. The hydration of benzonitrile was investigated as a model reaction and the ruthenium precursor was added to a 0.33M aqueous solution of benzonitrile at 100°C, while the reaction was monitored by gas chromatography. All the complexes checked, were found to be active and selective catalysts in the hydration process, providing benzamide as a specific reaction product. The most relevant results were obtained by using ruthenium complexes, bearing a nitrogen-containing ligand, which led to appropriate production of benzamide. The most effective ruthenium complex was found to be an efficient catalyst for the selective hydration of a large number of other nitriles.

Efficient lactam synthesis

Lactams, libraries of lactams, and an efficient method of synthesizing a lactam, including a γ-lactam, in which an α-diazoacetamide of the general structure (I) is reacted under conditions promoting intramolecular C—H insertion, for example in the presenc

Efficient lactam synthesis

Lactams, libraries of lactams, and an efficient method of synthesizing a lactam, including a γ-lactam, in which an a-diazoacetamide of the general structure (I) is reacted under conditions promoting intramolecular C-H insertion, for example in the presenc

Efficient lactam synthesis

Lactams, libraries of lactams, and an efficient method of synthesizing a lactam, including a γ-lactam, in which an α-diazoacetamide of the general structure (I) is reacted under conditions promoting intramolecular C—H insertion, for example in the presenc

Organic Syntheses without Solvent: Preparation of Sulfones and Dithioacetals

Sulfones are prepared by alkylation of sulfinate salts under solid-liquid phase-transfer catalysis without solvent; dithioacetals are obtained by heterogeneous uncatalyzed reactions of potassium arenethiolates and gem-dihaloalkanes.In both cases, the yields are high and the reaction conditions are mild.Some limitations are given.