3506-54-5Relevant academic research and scientific papers
Synthesis of enaminones containing diverse N,N-disubstitution via simple transamination: a study with sustainable catalyst-free operation
Gao, Yong,Liu, Yunyun,Wei, Li,Wan, Jieping
, p. 5547 - 5555 (2017/09/23)
Abstract: A systematic investigation on the synthesis of β-enaminones containing diverse N,N-disubstitution via the transamination of N,N-dimethyl amino functionalized β-enaminones and secondary amines has been conducted by employing biomass available green solvent ethyl lactate as reaction medium. A class of β-enaminones containing different N,N-disubstitutions have been smoothly synthesized under the sustainable conditions without using any catalyst.
Scalable synthesis of enaminones utilizing Gold's reagents
Schuppe, Alexander W.,Cabrera, James M.,McGeoch, Catherine L.B.,Newhouse, Timothy R.
, p. 3643 - 3651 (2017/06/13)
Several Gold's reagents were synthesized from cyanuric chloride and N,N-dialkylformamides. These synthetic equivalents of N,N-dimethylformamide dimethyl acetal were used in an optimized and scalable procedure for the regioselective synthesis of a variety
Electrosynthesis of enaminones directly from methyl ketones and amines with nitromethane as a carbon source
Xu, Kun,Zhang, Zhenlei,Qian, Peng,Zha, Zhenggen,Wang, Zhiyong
supporting information, p. 11108 - 11111 (2015/07/02)
An efficient and mechanistically different method for the electrosynthesis of enaminone directly from methyl ketones, amines and nitromethane was developed. This transition-metal-free method proceeded at room temperature to give a wide array of enaminones
Acetylide Ion (C22-) as a synthon to link electrophiles and nucleophiles: A simple method for enaminone synthesis
Yu, Dingyi,Sum, Yin Ngai,Ean, Amanda Chng Cheng,Chin, Mei Ping,Zhang, Yugen
, p. 5125 - 5128 (2013/06/27)
Friendly competition: A three-component reaction system composed of calcium carbide, an aryl aldehyde, and an amine gave enaminones or propargylamines (see picture) in a predictable manner through competitive pathways. The system enables the cost-efficient synthesis of a variety of enaminones from readily accessible small molecules and demonstrates the versatility of the acetylide ion, which can be used to bridge electrophiles and nucleophiles. Copyright
AMINOLYSIS OF VINYLAMMONIUM SALTS. EFFECTS OF STRUCTURE AND MEDIUM
Kravchenko, V. V.,Popov, A. F.,Kotenko, A. A.
, p. 1332 - 1336 (2007/10/02)
The kinetics of the aminolysis of a series of vinylammonium salts ZCH=CHN+R3*X- were investigated in polar solvents and in water at 25 deg C.A quantitative assessment was made of the effect of the nature of the medium and the structure of activating group Z on the rate of the investigated processes.The aminolysis rate of the salts increases with increase in the donating characteristics of the solvent on account of the greater stabilization of the transition state compared with the initial state.Increase in the accepting characteristics of the medium leads to retardation of the process as a result of increase in the electrophilic solvation of the amine in the initial state.
