35088-89-2

Usage

Uses

Used in Pharmaceutical Research:
1-(4-Methoxyphenylsulfonyl)piperidine, 97% is used as a building block for the development of various therapeutic agents. Its versatile reactivity and potential pharmacological properties make it a valuable component in the creation of drugs for the treatment of neurological disorders, pain management, and other medical conditions.
Used in Organic Synthesis:
In the field of organic synthesis, 1-(4-Methoxyphenylsulfonyl)piperidine, 97% serves as a key intermediate compound. Its unique structure allows for further chemical reactions and modifications, enabling the synthesis of a wide range of complex organic molecules for various applications.

InChI:InChI=1/C12H17NO3S/c1-16-11-5-7-12(8-6-11)17(14,15)13-9-3-2-4-10-13/h5-8H,2-4,9-10H2,1H3

Upstream product

• 110-89-4 piperidine 
• 98-68-0 4-methoxy-phenyl-sulphonyl chloride 
• 35856-62-3 1-piperidinesulfonyl chloride 
• 100-66-3 methoxybenzene 
• 261789-26-8 4-nitrophenyl 4-methoxybenzenesulfonate 
• 766-09-6 1-ethyl-piperidine 
• 1950-68-1 4-methoxybenzenesulfonyl hydrazide 
• 6462-50-6 sodium 4-methoxybenzenesulfinate 
• 5720-07-0 4-methoxyphenylboronic acid 
• 696-62-8 para-iodoanisole 
• 663175-94-8 pentafluorophenyl 4-methoxyphenylsulfonate ester 
• 154853-46-0 2,4-dinitrophenyl 4-methoxybenzenesulfonate 

Downstream Products

• 99986-71-7 4-(piperidin-1-ylsulfonyl)phenol 

Relevant academic research and scientific papers

Iodine-catalyzed sulfonylation of sulfonyl hydrazides with: Tert -amines: A green and efficient protocol for the synthesis of sulfonamides

This study provides a direct, sustainable and eco-friendly method for the synthesis of various sulfonamides via the sulfonylation of sulfonyl hydrazides with tert-amines. The method utilizes sulfonyl hydrazides to oxidize and couple with tertiary amines through selective cleavage of C-N bonds. In this reaction, molecular iodine was used as the catalyst and t-butyl hydroperoxide was used as the oxidant.

Hypervalent Iodine Mediated Sulfonamide Synthesis

A new metal-free sulfonylation reaction is described. The method takes advantage of the Umpolung reactivity and group-transfer properties of iodine(III) compounds, combining hypervalent iodine reagents and sulfinate salts to deliver a clean and mild transfer of sulfonyl groups to amines and anilines. A total of 25 sulfonamides was synthesised in up to 99 % yield, even on gram-scale. The reaction mechanism was investigated by ESI-MS and DFT calculations.

TBAI-catalyzed selective synthesis of sulfonamides and β-aryl sulfonyl enamines: coupling of arenesulfonyl chlorides and sodium sulfinates with tert-amines

A simple, practical and metal-free method has been developed for the synthesis of sulfonamides and β-arylsulfonyl enamines via the selective cleavage of C-N and C-H bonds through the iodine-catalyzed oxidation of arenesulfonyl chlorides and sodium sulfinates with tert-amines. The method uses commercially available inexpensive catalysts and oxidants, and has a wide substrate scope and operational simplicity.

Method for synthesizing benzenesulfonamide compound by using benzenesulfonyl chloride compound and secondary amine through metal-free catalysis

The invention provides a method for synthesizing a benzenesulfonamide compound by using a benzenesulfonyl chloride compound and secondary amine through metal-free catalysis. The method comprises the following steps: taking the benzenesulfonamide compound

Method for synthesizing benzenesulfonamide compound by using benzenesulfonohydrazide derivative and secondary amine through metal-free catalysis

The invention provides a method for synthesizing a benzenesulfonamide compound by using a benzenesulfonohydrazide derivative and secondary amine through metal-free catalysis. The method comprises thefollowing steps: taking the benzenesulfonohydrazide deri

Iron-catalyzed synthesis of arylsulfinates through radical coupling reaction

A novel strategy for installation of a sulfonyl fragment into arenes has been accomplished via an iron-catalyzed radical coupling reaction. Arene radicals derived from diaryliodoniums via single electron transfer reaction combine with sulfoxylate anion radicals readily generated from commercially available rongalite (HOCH2SO2Na·2H2O) to afford arylsulfinates efficiently at room temperature. In this protocol, a broad range of functional groups are tolerated to give products in good yields.

Synthesis of sulfonamides: Via copper-catalyzed oxidative C-N bond cleavage of tertiary amines

A copper-catalyzed coupling reaction of sulfonyl chlorides with tertiary amines via the oxidative C-N bond cleavage of tertiary amines was developed. Sulfonamides were synthesized using this strategy in moderate to good yields. The reaction was applicable to various tertiary amines, as well as sulfonyl chlorides.

Synthesis and Biological Evaluation of Polar Functionalities Containing Nitrodihydroimidazooxazoles as Anti-TB Agents

Novel polar functionalities containing 6-nitro-2,3-dihydroimidazooxazole (NHIO) analogues were synthesized to produce a compound with enhanced solubility. Polar functionalities including sulfonyl, uridyl, and thiouridyl-bearing NHIO analogues were synthes

Palladium-catalyzed sulfination of aryl and heteroaryl halides: Direct access to sulfones and sulfonamides

A novel palladium-catalyzed sulfination of aryl and heteroaryl halides is described. This reaction operates under mild conditions and provides access to a wide range of aryl and heteroaryl sulfinates, a useful and versatile class of synthetic intermediates. Capitalizing on this sulfination reaction, one-pot protocols allowing direct access to sulfones and sulfonamides have also been developed. The practicality of these transformations is illustrated with the parallel synthesis of analogues of the drug Viagra.