3510-48-3

Upstream product

• 623-03-0 4-Cyanochlorobenzene 
• 5315-86-6 4-chlorobenzaldehyde semicarbazone 
• 104-88-1 4-chlorobenzaldehyde 
• 102461-59-6 (α-anilino-4-chloro-benzyl)-malonic acid diethyl ester 
• 31061-79-7 benzoic acid (4-chlorobenzylidene)hydrazide 
• 19277-54-4 p-chlorophenyldiazomethane 
• 80414-86-4 3-Hydrazinosulfonyl-5-chlorosalicylic acid 
• 90701-80-7 N-(o-azidobenzoyl)-p-chlorobenzaldehyd hydrazone 
• 3485-71-0 N-(4-Chlor-benzyliden)-4-rhodan-anilin 
• 691-38-3 (Z)-4-methyl-2-pentene 
• 110-82-7 cyclohexane 
• 354-58-5 1,1,1-Trichloro-2,2,2-trifluoroethane 
• 52372-80-2 (4-chlorobenzylidene)hydrazine 
• 558-13-4 carbon tetrabromide 

Downstream Products

• 5121-74-4 4,4'-dichlorostylbene 
• 92253-54-8 N,N'-bis-(4-chloro-benzyl)-hydrazine 
• 39122-61-7 3-(4-chloro-benzylideneamino)-2-(4-chloro-phenyl)-6-phenyl-2,3-dihydro-[1,3,5]thiadiazin-4-one 
• 722-32-7 (2-(4-chlorophenyl)methylene)hydrazolyl-1,3-thiazolidin-4-one 
• 904-60-9 4-chloro-benzaldehyde [5-(4-chloro-benzylidene)-4-oxo-thiazolidin-2-ylidene]-hydrazone 
• 111474-68-1 4,4'-Dichlor-benzaldazin-monoxyd 
• 91122-50-8 2,2'-Bis-(4-chloro-phenyl)-[3,3']bithiazolidinyl-4,4'-dione 
• 3395-81-1 4-chlorobenzaldehyde dimethyl acetal 
• 2403-61-4 p-chlorobenzaldehyde diethyl acetal 
• 2510-74-9 (E)-1,2-di(4-chlorophenyl)ethene 
• 120106-66-3 4,5-bis(4-chlorophenyl)-2H-1,2,3-triazole 
• 104-88-1 4-chlorobenzaldehyde 
• 134898-23-0 p-chlorobenzyldehyde azine-3,3'-disulfonyl chloride 
• 5406-33-7 4-chlorobenzyl acetate 

Relevant academic research and scientific papers

Reaction of aldehydes with hydrazine in the system sulfur-alkali

Dissolution of sulfur in the system hydrazine hydrate-alkali leads to strong activation of hydrazine, so that the latter readily reacts at room temperature with aldehydes of the aromatic and thiophene series to give the corresponding aldehyde azines in high yield. The mechanism of activating effect of sulfur is discussed.

Ruthenium(ii)-catalysed 1,2-selective hydroboration of aldazines

Herein, an efficient and simple catalytic method for the selective and partial reduction of aldazines using ruthenium catalyst [Ru(p-cymene)Cl2]2 (1) has been accomplished. Under mild conditions, aldazines undergo the addition of pinacolborane in the presence of a ruthenium catalyst, which delivered N-boryl-N-benzyl hydrazone products. Notably, the reaction is highly selective, and results in exclusive mono-hydroboration and desymmetrization of symmetrical aldazines. Mechanistic studies indicate the involvement of in situ formed intermediate [{(η6-p-cymene)RuCl}2(μ-H-μ-Cl)] (1a) in this selective hydroboration.

Dihydrazone compound high in affinity with Abeta protein and Tau protein, derivative thereof, and applications of dihydrazone compound and derivative

The invention provides a dihydrazone compound high in affinity with Abeta protein and Tau protein, a derivative thereof, and applications of the dihydrazone compound and the derivative. The structureof the dihydrazone compound is represented by formula I. The dihydrazone compound can be directly taken as a fluorescence probe used for detecting neurofibrillary tangles in vivo or in tissue samples;when the dihydrazone compound is adopted in nuclear medicine imaging, appropriate radioisotopes are needed for labeling. The dihydrazone compound is especially suitable to be used for diagnosis of neurodegenerative diseases, and diagnosis of patients with diseases with Abeta plaques including Alzheimer's disease.

C[sbnd]N bond formation in alicyclic and heterocyclic compounds by amine-modified nanoclay

In the current protocol, amine functionalized montmorillonite K10 nanoclay (NH2-MMT) was applied to catalyze the formation of C[sbnd]N bonds in the synthesis of azines and 2-aminothiazoles at room temperature. In comparison with the current methods of C[sbnd]N bond formation, this approach displays specific advantages include atom economy, clean conversion, design for energy efficiency, the use of nontoxic and heterogeneous catalyst, higher purity and yields, safer solvent and reagents for this organic transformation.

Mononuclear half-sandwich iridium and rhodium complexes through C?H activation: Synthesis, characterization and catalytic activity

A series of mononuclear half-sandwich cyclometalated group 9 (Ir and Rh) metal complexes were synthesized in good yields through metal-mediated C?H bond activation. These air-stable C, N-chelate mode complexes have similar solid state structures. Both experimental results and DFT calculations confirmed that no binuclear complexes were generated in this reaction. The iridium complex 3a exhibited good catalytic activity for the reduction of both electron-rich and electron-poor aryl imines with low catalyst loading in the presence of formic acid/triethylamine (F/T) azeotropic mixture. All complexes were fully characterized by elemental analysis and IR and NMR spectroscopies. The structures of 1a, 1b, 2a, 3a and 4b (see chemical structure formula in Scheme 1 and Scheme 2) were further confirmed by single-crystal X-ray analysis.

A Copper-Benzotriazole-Based Coordination Polymer Catalyzes the Efficient One-Pot Synthesis of (N′-Substituted)-hydrazo-4-aryl-1,4-dihydropyridines from Azines

A series of new (N′-substituted)-hydrazo-4-aryl-1,4-dihydropyridines was successfully synthesized via a facile one-pot catalytic pathway utilizing azines and propiolate esters as starting materials and a one-dimensional copper benzotriazole-based coordination polymer as catalyst. In the absence of catalyst, the corresponding 5-substituted 4,5-dihydropyrazoles were formed in moderate to high yields. Fine-tuning of the catalysts allowed us to gain more insights regarding the plausible reaction mechanism. (Figure presented.).

Cs2CO3-mediated decomposition of N-tosylhydrazones for the synthesis of azines under mild conditions

Abstract: A facile, environmentally and efficient Cs2CO3-mediated decomposition of N-tosylhydrazones reaction has been developed for the synthesis of functionalized azines under mild conditions. This method offers broad substrate scope, occurs as additive-free, without strong base conditions, utilizes readily available reactants, and forms products in good to high yields. Graphical Abstract: [Figure not available: see fulltext.]

Tungsten hexachloride nanoparticles loaded on montmorillonite K-10: a novel solid acid catalyst in the synthesis of symmetrical and unsymmetrical azines

In the present investigation, we have developed a novel technique to prepare azines using nano-WCl6 loaded on Montmorillonite K10 clay as a highly active catalyst. A variety of aldehydes and ketones were efficiently converted to the corresponding azines using catalytic amounts of nanosized WCl6/Mont. K10 under mild conditions. The nanostructures of WCl6 loaded on Mont. K10 as solid acid catalyst have been prepared by solid dispersion method. The advantages of this catalyst are rapid completion of the reactions, simplicity of performance, lack of pollution and mild and green reaction conditions. The morphologies, structure, and chemical components of parent and modified clay were successfully characterized using SEM, FT-IR, CV, XRD and EDX measurements.

Synthesis of Novel Heterocycles Derived from 4-Arylmethylene-2-phenyl-1,3-oxazole-5(4H)-ones

The acid hydrazide derivatives 2 were converted into pyrazolone, triazinone, and schiff bases. However, the reaction of Schiff base 12 with malononitrile or thioglycolic acid gives the pyrazolotriazinone or thiazolidinone derivative, respectively. The str

Direct synthesis of symmetrical azines from alcohols and hydrazine catalyzed by a ruthenium pincer complex: Effect of hydrogen bonding

Azines (2,3-diazabuta-1,3-dienes) are a widely used class of compounds with conjugated CN double bonds. Herein, we present a direct synthesis of azines from alcohols and hydrazine hydrate. The reaction, catalyzed by a ruthenium pincer complex, evolves dihydrogen and can be run in a base-free version The deh dro enative cou lin of benz lic and aliphatic alcohols led to good conversions and yields. Spectroscopic evidence for a hydrazine-coordinated dearomatized ruthenium pincer complex was obtained. Isolation of a supramolecular crystalline compound provided evidence for the important role of hydrogen bonding networks under the reaction conditions.