351416-13-2

Upstream product

• 351416-09-6 5-(4-chloro-phenyl)-2-methoxymethyl-6-phenyl-2H-pyridazin-3-one 
• 1679-18-1 4-Chlorophenylboronic acid 
• 491876-40-5 5-bromo-2-hydroxymethyl-6-phenyl-3(2H)-pyridazinone 
• 433330-74-6 3-(4-chloro-phenyl)-4-oxo-4-phenyl-butyric acid 
• 247158-79-8 5-Bromo-2-methoxymethyl-6-phenylpyridazin-3-one 
• 6332-83-8 2-(4-chlorophenyl)-1-phenylethanone 
• 433935-99-0 5-bromo-6-chloro-3-phenylpyridazine 
• 25026-34-0 4-chlorophenacetyl chloride 
• 132566-31-5 ethyl 3-(4-chlorophenyl)-4-phenyl-4-oxobutanoate 
• 1878-66-6 4-chlorophenylacetic Acid 
• 90766-97-5 5-bromo-6-phenylpyridazin-3(2H)-one 
• 433330-78-0 5-(4-chloro-phenyl)-6-phenyl-4,5-dihydro-2H-pyridazin-3-one 
• 136549-55-8 6-chloro-4-(4-chloro-phenyl)-3-phenyl-pyridazine 

Downstream Products

• 136549-55-8 6-chloro-4-(4-chloro-phenyl)-3-phenyl-pyridazine 

Relevant academic research and scientific papers

Pyridazines. Part 36: Synthesis and antiplatelet activity of 5-substituted-6-phenyl-3(2H)-pyridazinones

A convenient and efficient palladium-catalysed retro-ene-assisted method has been developed to prepare a series of 5-substituted-6-phenyl-3(2H)- pyridazinones as potential antiplatelet drugs. The most active compounds were those that contain a 3-phenyl-3-

Pyridazines. Part 35: Traceless solid phase synthesis of 4,5- and 5,6-diaryl-3(2H)-pyridazinones

A new method for the traceless solid phase synthesis of 3(2H)-pyridazinones has been developed employing dihydropyran-functionalized resin. The procedure has permitted the preparation of several diarylpyridazinones through a Suzuki cross-coupling reaction and cleavage conditions that promoted a retro-ene fragmentation.

Mono- and di-substituted 5,6-diphenyl-3-alkylaminopyridazines active as ACAT inhibitors

A series of mono- or di-para-substituted 5,6-diphenyl-3-alkylaminopyridazines were synthesized and their inhibitory activity against acyl-CoA:cholesterol acyltransferase (ACAT) was tested on the enzyme prepared from rat liver microsomes. The compound which combines a chlorine atom on the 6-phenyl ring and a n-hexylamino chain showed a significant enhancement of activity with respect to the unsubstituted derivative. Attempts to correlate the activity of the compounds to their structural features, also through theoretical calculations, are reported.

Pyridazines. Part 26: Efficient and regioselective Pd-catalysed arylation of 4-bromo-6-chloro-3-phenylpyridazine

The regioselective arylation at position 4 of 4-bromo-6-chloro-3-phenylpyridazine has been performed using a Suzuki cross-coupling reaction. This route allows access to a wide-ranging series of pharmacologically useful pyridazine derivatives and confirms

Pyridazines. Part 30:1 Palladium-catalysed synthesis of 5-substituted 6-phenyl-3(2H)-pyridazinones asissted by a retro-ene transformation

The efficient one-pot functionalization, through palladium-catalysed reactions, of position 5 of the 6-phenyl-3(2H)-pyridazinone system has been performed using a retro-ene-assisted fragmentation. This route allows access through a short synthetic sequenc

Pyridazines part XXIII: Efficient arylation at position 5 of the 6-phenyl-(2H)-pyridazin-3-one system using a Suzuki cross-coupling reaction

A highly efficient procedure for introducing aryl or heteroaryl rings at position 5 of the 6-phenyl-(2H)-pyridazin-3-one system using a Suzuki cross-coupling reaction has been developed in the search for new platelet aggregation inhibitors.