35152-42-2

Upstream product

• 110-58-7 n-Pentylamine 
• 108-93-0 cyclohexanol 
• 108-91-8 cyclohexylamine 
• 109-72-8 n-butyllithium 
• 1074-58-4 N-(cyanomethyl)cyclohexylamine 
• 110-53-2 1-Bromopentane 
• 110426-45-4 C₁₁H₂₂N^(1-)*K⁽¹⁺⁾ 
• 108-88-3 toluene 
• 123-91-1 1,4-dioxane 
• 6281-14-7 1,3,5-tricyclohexyl-[1,3,5]triazinane 
• 110-59-8 pentanonitrile 
• 18292-76-7 N-(prop-2-yn-1-yl)cyclohexanamine 

Downstream Products

• 101-81-5 Diphenylmethane 
• 110426-40-9 C₁₁H₂₂N^(1-)*Li⁽¹⁺⁾ 
• 110426-45-4 C₁₁H₂₂N^(1-)*K⁽¹⁺⁾ 
• 108-88-3 toluene 
• 69592-01-4 6-[3-(N-Pentyl-N-cyclohexylaminocarbonyl)-propoxy]carbostyril 

Relevant academic research and scientific papers

Metal Acetylide Elimination: The Key Step in the Cascade Decomposition and Transformation of Metalated Propargylamines

Metal acetylide elimination facilitates a novel one-pot cascade metalation and elimination/addition route to a series of unsymmetrical secondary amines from the reaction of secondary propargylamines with organometallic reagents. Spectroscopic evidence suggests a dimetalated amido intermediate rather than an allene.

Chemoselective deprotection of N-allylic amines using DDQ

A highly chemoselective and simple method for the deprotection of N-allylic amines using DDQ has been developed. The use of DDQ in dichloromethane-water provides a mild and efficient one-step deallylation of a wide variety of orthogonally protected tertiary amine derivatives.

BESTIMMUNG DER IONENPAAR-BASIZITAT VON LITHIUM- UND KALIUMAMIDEN

Ion pair basicities of lithio and potassio salts of some secondary amines were determined by equilibration with benzyl compounds.With these bases it is possible to span a range of about 19 pK-units from pK = 27 up to 46.The structural dependence of thermodynamic as well as kinetic basicity is discussed.Some new effective amide bases for preparative purposes are recommended.For the first time the pK-value of toluene has been determined by direct equilibration.It amounts to 40.7 in tetrahydrofuran.

Monoalkylation of Primary Aliphatic Amines via N-Alkyl-N-(alkylthiomethyl)ammonium Chlorides. Evidence for the Formation of Stable N-Methylenealkylamines

Monomeric N-methylenealkylamines (3), formed from N-alkyl-N-(alkylthiomethyl)ammonium chlorides (5) are stable at -60 deg C and may be trapped with organometallic reagents to provide the N,N-dialkylamines (8).

A CONVENIENT SYNTHESIS OF UNSYMMETRICAL SECONDARY AMINES. IN SITU FORMATION OF UNSTABLE FORMALDEHYDE IMINES.

The monoalkylation of aliphatic and aromatic primary amines can be accomplished by the reaction of organolithium or grignard reagents with N-(cyanomethyl) or N-(aminomethyl) derivatives.