352-12-5

Basic information

• Product Name: Benzene, 1-chloro-4-(fluoromethyl)-
• CAS NO: 352-12-5
• Molecular Formula: C7H6ClF
• Molecular Weight: 144.576
• Mol File: 352-12-5.mol
• Article Data: 24

Chemical Properties

• CAS DataBase Reference: Benzene, 1-chloro-4-(fluoromethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzene, 1-chloro-4-(fluoromethyl)-(352-12-5)
• EPA Substance Registry System: Benzene, 1-chloro-4-(fluoromethyl)-(352-12-5)

Safety Data

• Hazardous Substances Data: 352-12-5(Hazardous Substances Data)

Upstream product

• 106-43-4 para-chlorotoluene 
• 7693-30-3 4-chlorobenzyl phenyl sulfide 
• 19350-69-7 4-chlorobenzaldehyde p-toluenesulfonylhydrazone 
• 15183-58-1 O-(4-chlorobenzyl) S-methyl carbonodithioate 
• 104-86-9 4-chlorobenzylamine 
• 622-95-7 4-chlorobenzyl bromide 
• 71742-09-1 1-(4-Chloro-benzyl)-2,4,6-triphenyl-pyridinium; fluoride 
• 104-83-6 1-Chloro-4-(chloromethyl)benzene 
• 873-76-7 para-Chlorobenzyl alcohol 

Downstream Products

• 19962-25-5 1-chloro-4-(phenoxymethyl)benzene 
• 33598-76-4 1-chloro-4-(ethoxymethyl)benzene 
• 873-76-7 para-Chlorobenzyl alcohol 
• 831-81-2 4-chlorophenyl(phenyl)methane 
• 85716-72-9 2-[(4-chlorophenyl)methyl]-1,4-dimethylbenzene 
• 477219-29-7 1-(fluoromethyl)-4-isopropylbenzene 
• 104-88-1 4-chlorobenzaldehyde 
• 92-52-4 biphenyl 
• 6425-43-0 4-(4'-chloro-benzyl)morpholine 

Relevant articles and documents

PROCESSES FOR FLUORINATION

The present technology relates to fluorination reactions. Specifically, processes useful for making the fungicide compound, DFT are disclosed. More broadly, also disclosed herein are processes useful for deoxyfluorination at the α-aromatic position of a given compound.

Thiourea-Catalyzed C?F Bond Activation: Amination of Benzylic Fluorides

We describe the first thiourea-catalyzed C?F bond activation. The use of a thiourea catalyst and Ti(OiPr)4 as a fluoride scavenger allows the amination of benzylic fluorides to proceed in moderate to excellent yields. Preliminary results with S- and O-based nucleophiles are also presented. DFT calculations reveal the importance of hydrogen bonds between the catalyst and the fluorine atom of the substrate to lower the activation energy during the transition state.

Expanding the repertoire of cyclopropenium ion phase transfer catalysis: Benzylic fluorination

The application of cyclopropenium ion as a phase transfer catalyst for benzylic fluorination in high yields is reported. Integral to the mechanisms of these fluorination reactions was the role of in situ derived cyclopropenium fluoride complexes, the existence of which was supported by 1H, 19F NMR and UV–Vis spectroscopy. Density functional theory calculations were applied to gain insight into the mechanism of these reactions.