35283-09-1

Usage

Uses

Used in Organic Synthesis:
(3-NITRO-PHENYL)-PROPYNOIC ACID ETHYL ESTER is used as a building block for creating diverse molecules with potential biological activities. Its unique structure allows for further chemical modifications, making it a valuable component in the synthesis of various organic compounds.
Used in Pharmaceutical Research:
In the pharmaceutical industry, (3-NITRO-PHENYL)-PROPYNOIC ACID ETHYL ESTER is used as a key intermediate in the development of new drugs. Its nitrophenyl and propynoic acid moieties contribute to its interesting chemical and pharmacological properties, which can be exploited to design and synthesize novel therapeutic agents.
Used in Structure-Activity Relationship Studies:
(3-NITRO-PHENYL)-PROPYNOIC ACID ETHYL ESTER is also utilized in the study of structure-activity relationships. By examining the effects of modifications to (3-NITRO-PHENYL)-PROPYNOIC ACID ETHYL ESTER, researchers can gain insights into the relationship between a molecule's structure and its biological activity, which is crucial for the design of more effective drugs.
Used in Organic Solvents:
Due to the presence of the ethyl ester group, (3-NITRO-PHENYL)-PROPYNOIC ACID ETHYL ESTER is suitable for use in organic solvents. This property makes it a valuable component in various chemical processes and reactions where organic solvents are required.

Upstream product

• 64-17-5 ethanol 
• 4996-15-0 3-(3-nitrophenyl)propynoic acid 
• 99-61-6 3-nitro-benzaldehyde 
• 111598-99-3 (Ethoxycarbonyliodomethyl)triphenylphosphonium iodide 
• 645-00-1 m-iodonitrobenzene 
• 623-47-2 propynoic acid ethyl ester 
• 3034-94-4 3-nitrophenylacetylene 
• 541-41-3 chloroformic acid ethyl ester 

Downstream Products

• 4996-15-0 3-(3-nitrophenyl)propynoic acid 

Relevant academic research and scientific papers

Concise Synthesis of Furo[2,3- b ]indolines via [3,3]-Sigmatropic Rearrangement of N -Alkenyloxyindoles

A concise new synthetic route to furo[2,3- b ]indolines has been developed by taking advantage of the reactivity of N -alkenyloxyindole intermediates. These compounds spontaneously undergo [3,3]-sigmatropic rearrangement followed by cyclization to form hemiaminals as single diastereomers. Tin-promoted N -hydroxyindole formation followed by conjugate addition to activated alkynes provides simple and modular access to a diverse array of N -alkenyloxyindoles and their corresponding furo[2,3- b ]indolines. Microscale high-throughput experimentation was used to facilitate investigation of the scope and tolerance of this transformation and related studies on the nucleophilic aromatic substitution and rearrangement of N -hydroxyindoles with halogenated arenes have also been evaluated.

Efficient Synthesis of Functionalized β-Keto Esters and β-Diketones through Regioselective Hydration of Alkynyl Esters and Alkynyl Ketones by Use of a Cationic NHC–AuICatalyst

Regioselective hydration of α-alkynyl esters and ketones by using a cationic NHC–AuIcatalyst results in β-keto esters and β-diketones, respectively. Controlled release of water in acetone by aldol self-condensation under the reaction conditions makes acetone as better solvent than 1,4-dioxane/water for the hydration of α-alkynyl esters having sensitive ester moieties.

(Ethoxycarbonyliodomethyl)triphenylphosphonium Iodide: A Convenient Reagent for the Direct Synthesis of β-Substituted Propiolic Acids via the Corresponding Esters

Reaction between (ethoxycarbonyliodomethyl)triphenylphosphonium iodide, potassium carbonate, and various aromatic or aliphatic aldehydes in a liquid solid two phases system gives β-substituted propiolic esters.The corresponding acids are obtained in good yield by hydrolysis.