35296-14-1

Usage

Uses

Used in Organic Synthesis:
8-Benzyl-1-oxa-8-azaspiro[4.5]decan-2-one is utilized as a building block in organic synthesis, providing a versatile structure that can be further modified or functionalized to create new compounds with desired properties.
Used in Drug Discovery:
In the field of drug discovery, 8-benzyl-1-oxa-8-azaspiro[4.5]decan-2-one serves as a valuable starting point for the development of new pharmaceutical agents. Its unique structure and potential pharmacological properties make it an attractive candidate for the design of novel therapeutic agents.
Used in Medicinal Chemistry:
8-Benzyl-1-oxa-8-azaspiro[4.5]decan-2-one is employed in medicinal chemistry for the exploration of its diverse pharmacological properties. Researchers can use 8-benzyl-1-oxa-8-azaspiro[4.5]decan-2-one to investigate its interactions with biological targets and evaluate its potential as a therapeutic agent.
Used in Pharmaceutical Research:
In pharmaceutical research, 8-benzyl-1-oxa-8-azaspiro[4.5]decan-2-one is used to study its bioactivity and drug-like properties. This can help in the identification of new drug candidates and the optimization of their pharmacological profiles for improved efficacy and safety.

InChI:InChI=1/C15H19NO2/c17-14-6-7-15(18-14)8-10-16(11-9-15)12-13-4-2-1-3-5-13/h1-5H,6-12H2

Upstream product

• 35296-24-3 3-(1-benzyl-1,2,3,6-tetrahydro-pyridin-4-yl)-propionamide 
• 19867-34-6 N-benzyl-1-oxa-6-azaspiro[2,5]-octane 
• 105-53-3 diethyl malonate 
• 100-52-7 benzaldehyde 
• 167364-29-6 1-oxa-8-aza-spiro[4.5]decan-2-one 

Relevant academic research and scientific papers

4(SPIROPIPERIDINYL)METHYL SUBSTITUTED PYRROLIDINES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY

3-Substituted pyrrolidines having a spiropiperidinylmethyl substituent on the 4-position of the ring are useful as modulators of chemokine receptor activity. In particular, these compounds are useful as modulators of the chemokine receptors CCR-3 and/or CCR-5.

SYNTHESIS OF 3-METHYLENE-1-OXA-8-HETERASPIRODECAN-2-ONES AND 1-OXA-8-HETERASPIRODECAN-2-ONES. NOVEL FORMATION AND CRYSTAL STRUCTURE OF 3--1-OXA-8-THIASPIRODECAN-2-ONE

A series of new 3-methylene-1-oxa-8-heteraspirodecan-2-ones have been prepared as the first members of the family.Reaction of 1-oxa-6-heteraspirooctanes with diethyl malonate, followed by hydrolysis, gave 3-carboxy-1-oxa-8-heteraspirodecan-2-ones.The carboxy lactone, upon treatment with diethylamine and formaldehyde followed by sodium acetate and acetic acid, produced α-methyl-eneheteraspiro lactones in good yields and in high purity.Moreover, the carboxy lactones could be decarboxylated smoothly to give 1-oxa-8-heteraspirodecan-2-ones in good yields.The present method appears to be superior to the widely used Reformatsky reaction since only low yields of the required lactones could be obtained when applied in the work reported herein.An investigation of dilithiated acetic acid as a co-reactant with spiro epoxides of heteracyclohexyl systems was undertaken but rather than the expected γ-lactones, unusual γ-hydroxylactones were obtained.Apparently, the anionic behavior of the dilithiated acetic acid caused the condensation to occur.All lactone systems were characterized via IR, 1H NMR and 13C NMR analysis and mass spectral data.A single crystal analysis by X-ray diffraction of 3--1-oxa-8-thiaspirodecane-2-one l2l2l, Z=4, a=5.916(2), b=11.585(3), c=21.986(5) Angstroem, T=138 K> was completed.Least-squares refinement converged to R=0.045 for 1319 diffractometer data.Both thiacyclohexyl rings are in the chair conformation and have C-O bonds which are axial.The sulfur ring with the hydroxyl group is orientationally disordered.This is the first example of such a fused heterocycle in which a structure of the crystal has been reported.