3543-98-4

Usage

Chemical Family

2,2-dichloro-1,3-diphenylaziridine belongs to the aziridine family.

Physical State

It is a colorless liquid.

Odor

It has a strong, pungent odor.

Usage

It is used as a building block for organic synthesis and pharmaceutical production.

Application

It is also used as a reagent in the research and development of new chemical compounds.

Hazardous Nature

2,2-dichloro-1,3-diphenylaziridine is a hazardous substance.

Health Risks

It can cause skin and eye irritation, and prolonged exposure may lead to harmful health effects.

Safety Measures

Appropriate safety measures and handling procedures should be followed when working with this chemical.

Upstream product

• 56-23-5 tetrachloromethane 
• 538-51-2 benzylidene phenylamine 
• 116-16-5 1,1,1,3,3,3-hexachloro-propan-2-one 
• 1749-19-5 phenyl(1-phenylethylidene)amine 
• 67-66-3 chloroform 
• 100-52-7 benzaldehyde 
• 62-53-3 aniline 
• 76772-99-1 Phenyl-[2,2,2-trichloro-1-phenyl-eth-(E)-ylidene]-amine 
• 1750-36-3 (E)-N-benzylidenebenzenamine 

Downstream Products

• 31529-00-7 4-(2-morpholin-4-yl-2,N-diphenyl-acetimidoyl)-morpholine 
• 74-87-3 methylene chloride 
• 115-10-6 Dimethyl ether 
• 7476-66-6 methyl 2-chloro-2-phenylethanoate 
• 3558-61-0 methyl 2-methoxy-2-phenylacetate 
• 142-04-1 aniline hydrochloride 
• 54755-95-2 2-oxo-1-phenyl-2-(phenylamino)ethyl acetate 
• 5110-77-0 N-phenyl-α-chlorophenylacetamide 
• 10295-54-2 Phenyl-chlor-essigsaeure-<4-nitro-anilid> 
• 69377-94-2 α-Chlor-α-phenyl-2-nitroacetanilid 
• 92884-95-2 Acetic acid (4-nitro-phenylcarbamoyl)-phenyl-methyl ester 
• 92884-96-3 Acetic acid (2-nitro-phenylcarbamoyl)-phenyl-methyl ester 
• 92884-98-5 Acetic acid (4-chloro-2-nitro-phenylcarbamoyl)-phenyl-methyl ester 
• 10295-39-3 α-Chlor-α-phenyl-N-phenyl-acetimidoylchlorid 

Relevant academic research and scientific papers

Ultrasonic assisted synthesis of gem-dichloroaziridine derivatives using Mg/CCl4 under neutral conditions

A novel and convenient method for synthesis of gem-dichloroaziridine derivatives was reported in that was utilized Mg powder with CCl4 for dichlorocarbene generation under ultrasonic irradiation. In this clean and efficient reaction procedure,

Nanocrystalline magnesium oxide as a solid base catalyst promoted one pot synthesis of gem-dichloroaziridine derivatives under thermal conditions

In this study, efficient and mild synthesis of gem-dichloroaziridines from Schiff bases in the presence of nanocrystalline magnesium oxide/chloroform as a novel source of dichlorocarbene intermediate under thermal conditions have been described. The react

PEG400-enhanced synthesis of gem-dichloroaziridines and gem-dichlorocyclopropanes via in situ generated dichlorocarbene

PEG400 is employed as an efficient phase transfer catalyst for the cycloaddition reaction of imines with dichlorocarbene, which is generated in situ from chloroform and sodium hydroxide, to give gem-dichloroaziridines in moderate to excellent yields at ambient temperature. This protocol is also extended to the synthesis of cyclopropanes from a variety of alkenes. In this study, PEG400 behaves as a phase transfer reagent thanks to its ability to coordinate with alkali metal cations. Notably, the one-pot synthesis of gem-dichloroaziridines from benzaldehyde and aromatic amines has also been successfully performed. The in situ generated acid, derived from CO2 and H2O, can also be effectively applied to promote the amide synthesis via the gem-dichloroaziridine pathway. The application of the gem-dichlorocyclopropane as a platform chemical is also briefly demonstrated, to afford the 2-phenylacrylaldehyde derivative via a ring-opening reaction. The Royal Society of Chemistry 2013.

Sonocatalyzed facile and mild one pot synthesis of gem-dichloroaziridine derivatives under alkaline conditions

In this research, rapid and efficient preparation of 2,2-dichloro-1,3- diarylaziridines through the reaction of Schiff base compounds with dichlorocarbene yielded in situ from chloroform and sodium hydroxide without any phase transfer catalyst under ultrasonic irradiation is described. The advantages of this reaction are very short reaction times, excellent product yields, simplicity of the method and high purity of products.

A novel catalyst-free one-pot synthesis of some new N-(α- hydroxybenzyl)formamides by treatment of 2,2-dichloroaziridines with dimethyl sulfoxide and water under neutral conditions

A novel, mild, and efficient method is reported for the preparation of new N-(α-hydroxybenzyl)formamides in excellent yields and appropriate reaction times through the reaction of 2,2-dichloroaziridines with aqueous DMSO as the O-donor under neutral condi

Ultrasonic-assisted synthesis of 1,3-diaryl-2,2-dichloroaziridine derivatives in the presence of phase-transfer catalyst under low-concentration alkaline conditions

In this research, rapid and efficient preparation of 1,3-diaryl-2,2- dichloroaziridines through the reaction of Schiff base compounds with dichlorocarbene yielded in situ in the presence of cetyltrimethylammonium bromide (CTAB) as phase-transfer catalyst

Mild, convenient and efficient synthesis of novel 2,2-dichloro-1,3- diarylaziridines from Schiff bases by phase transfer CTAB catalysis under low concentration alkaline conditions

A mild and efficient method for preparation of novel 2,2-dichloro-1,3- diarylaziridines from Schiff base compounds in the presence of N-cetyl-N,N,N-trimethyl ammonium bromide (CTAB) as phase transfer catalyst has been described. The reaction is dramatical

Novel synthesis of gem-dichloroaziridines from imines via the KF/Al 2O3-promoted generation of dichlorocarbene from chloroform

KF/Al2O3 was found to be an efficient base for the reaction of imines with chloroform in acetonitrile to give gem- dichloroaziridines 2 in moderate to high yields. The KF/ Al2O 3-promoted dichloroaziridination c

Synthesis of 2,2-Dichloro-1,3-diarylaziridines by Reduction of Trichloroacetophenone Imines

2,2-Dichloro-1,3-diarylaziridines, usually obtained by addition of dichlorocarbene to benzylideneanilines, were synthesized by reaction of N-aryl-α,α,α-trichloroacetophenone imines with lithium aluminium hydride in ether.