35547-70-7Relevant articles and documents
Synthesis and Computational Studies on Optoelectronically Important Novel Acridin-Isoindoline-1,3-Dione Derivatives
Mane, Smita,Katagi, Kariyappa,Melavanki, Raveendra
, (2019)
A series of novel 2-(4-(acridin-9-ylamino)phenyl)isoindoline-1,3-dione derivatives were designed and synthesized namely 2-(4-(4-methoxyacridin-9-ylamino)phenyl)isoindoline-1,3-dione [S1], 2-(4-(3-chloroacridin-9ylamino)phenyl)isoindoline-1,3-dione [S2], 2-(4-(2-fluor oacridin-9ylamino)phenyl)isoindoline-1,3-dione [S3], 2-(4-(1,4-dichloroacridin-9ylamino) phenyl)isoindoline-1,3-dione [S4]. The photophysical, thermal properties of these compounds were characterized by the spectroscopic and thermographic method. The absorbance and fluorescence spectra of these derivatives were recorded in different solvents to understand the role of solute and solvent interaction. The compounds showed high thermal stability with thermal decomposition temperatures at 5% weight loss in a range of 250–287?°C. Compared with these compounds, donor groups containing derivatives exhibited excellent properties as fluorescent compounds. Computational studies were done using DFT (Density Functional Theory) G09 software (B3LYP/6-311G++V(d,p)) basis sets in order to calculate the optical band gap and FMO (Frontier Molecular Orbital) energies. The chemical stability of the four derivatives was determined by means of chemical hardness (η) using HOMO-LUMO energies.
Novel synthetic acridine derivatives as potent DNA-binding and apoptosis-inducing antitumor agents
Lang, Xuliang,Li, Lulu,Chen, Yuzong,Sun, Qinsheng,Wu, Qin,Liu, Feng,Tan, Chunyan,Liu, Hongxia,Gao, Chunmei,Jiang, Yuyang
, p. 4170 - 4177 (2013/07/27)
Acridine derivatives have been explored as DNA-binding anticancer agents. Some derivatives show undesired pharmacokinetic properties and new derivatives need to be explored. In this work, a series of novel acridine analogues were synthesized by modifying previously unexplored linkers between the acridine and benzene groups and their antiproliferative activity and the DNA-binding ability were evaluated. Among these derivatives, compound 5c demonstrated DNA-binding capability and topoisomerase I inhibitory activity. In K562 cell lines, 5c induced apoptosis through mitochondria-dependent intrinsic pathways. These data suggested that compound 5c and other acridine derivatives with modified linkers between the acridine and benzene groups might be potent DNA-binding agents.
The Intercalation of 6-Chloro-substituted-9-amino>acridines with DNA
Kitchen, S. E.,Wang, Yueh-Hwa,Baumstark, A. L.,Wilson, W. D.,Boykin, D. W.
, p. 940 - 944 (2007/10/02)
A series of 6-chloro-2-substituted -9-amino>acridines has been prepared.The binding affinities and the unwinding angles for the acridine derivatives, relative to ethidium, were determined from viscometric titrations with ccs-DNA.
