59304-30-2

Upstream product

• 6269-27-8 3-chloroacridin-9(10H)-one 
• 35547-70-7 3,9-dichloroacridine 
• 104-88-1 4-chlorobenzaldehyde 
• 622-37-7 Phenyl azide 
• 386759-75-7 C₁₃H₉ClFN 
• 108-42-9 3-chloro-aniline 
• 6630-33-7 ortho-bromobenzaldehyde 
• 92044-36-5 4-Chlor-2'-iod-diphenylmethan 
• 615-42-9 1,2-Diiodobenzene 
• 62-53-3 aniline 
• 586-96-9 Nitrosobenzene 
• 1512859-12-9 C₁₉H₁₄Cl₂N₂ 
• 67-66-3 chloroform 
• 101-17-7 3-chlorodiphenylamine 

Downstream Products

• 6269-27-8 3-chloroacridin-9(10H)-one 
• 132239-72-6 N-(4-tolyl)-10-methyl-3(10H)-acridonimine 
• 132239-73-7 N-(methoxyphenyl)-10-methyl-3(10H)-acridonimine 
• 132239-95-3 3-(4-tolylamino)-10-methyl-9(10H)-acridone 
• 132239-76-0 N-(4-carboxyphenyl)-10-methyl-3(10H)-acridonimine 
• 132239-96-4 3-(4-methoxyphenylamino)-10-methyl-9(10H)-acridone 
• 132239-75-9 N-(4-nitrophenyl)-10-methyl-3(10H)-acridonimine 

Relevant academic research and scientific papers

Method for preparing acridine derivative

The invention relates to a method for preparing an acridine derivative, and specifically relates to a method for preparing the acridine derivative from an organic azide compound and a benzene compoundunder the action of an acid. According to the method disclosed by the invention, no transition metal catalyst is used, and the acridine derivative with an anthracene structure is obtained from a simple and easily-available raw material through simple operation steps.

Rh(III)-catalyzed synthesis of unsymmetrical acridines from aldehydes and azides using transient directing strategy in biomass-derived γ-valerolactone

An Rh(III)-catalyzed synthesis of unsymmetrical acridines from aldehydes and azides through bilateral cyclization process in biomass-derived γ-valerolactone has been developed. The in situ-generated imino directing group (DG) from aldehyde and catalytic a

Nitrogen-Iodine Exchange of Diaryliodonium Salts: Access to Acridine and Carbazole

A nitrogen-iodine exchange protocol of diaryliodonium salts with sodium azide salt is developed for general construction of significant functional acridines and carbazoles, in which introduction of nitrogen at a late stage was successfully established avoiding heteroatom incompatibility. Inorganic sodium azide served as the sole nitrogen atom source in this transformation. The diversiform functional acridines and carbazoles were comprehensively achieved through annulated diaryliodonium salts, respectively. Notably, Acridine orange (a fluorescent indicator for cell lysosomal dye) and Carprofen (a nonsteroidal anti-inflammatory drug) were efficiently established through this protocol.

Nitrogen anthracene class compound and its synthetic method and application (by machine translation)

The invention discloses a formula (2) shown in nitrogen anthracene class of compound and its synthetic method, high Iodized salt as reaction raw material, in the inorganic nitrogen reagent, additive, water, alkali, under the action of the metal catalyst, in the 80 - 150 °C conditions, reacts in a solvent 12 - 60 hours to obtain various nitrogen anthracene class compounds. The invention by post method of introducing nitrogen atoms, to avoid the early stage in the reaction of the nitrogen heterocyclic to metal catalyst of the reaction conditions such as not compatibility; in addition, high Iodized salt in the full utilization of the two aryl, shows that the method of the invention atom economy. Prepared by the method of the invention can be further applied [...] compound of the fluorescent indicator acridine orange synthesis. (by machine translation)

Rh(III)-Catalyzed bilateral cyclization of aldehydes with nitrosos toward unsymmetrical acridines proceeding with C-H functionalization enabled by a transient directing group

A Rh(iii)-catalyzed bilateral cyclization was developed for the efficient construction of acridines proceeding with C-H functionalization whereby in situ formation and removal of an imino transient directing group in the presence of catalytic amount of BnNH2 are achieved. In this transformation, a sequential Rh(iii)-catalyzed C-H amination, cyclization, and aromatization process was involved.

Preparation method of multi-functional group acridine compound and derivative thereof

The present invention relates to a preparation method of a multi-functional group acridine compound and a derivative thereof. According to the present invention, specifically a bisphosphine ligand and palladium complex catalyzed series connection coupling/cyclization reaction is used to prepare the acridine compound represented by a formula I, wherein various groups are defined in the specification; and the method has advantages of mild reaction condition, simple operation and wide substrate applicability, and the multi-functional group acridine compound and the derivative thereof can be prepared in the high yield manner. The formula I is defined in the specification.

Facile synthesis of acridines via Pd(0)-diphosphine complex-catalyzed tandem coupling/cyclization protocol

A facile and efficient approach for the synthesis of a variety of acridines via the tandem coupling/cyclization of substituted 2-bromobenzaldehydes and anilines is described. The reaction can be accomplished with ease in the presence of a catalytic amount of Pd2(dba)3 and diphosphine ligand dppf, providing a broad range of substituted acridines in good to excellent yields (up to 99%). The Lewis acid, AlCl3, is required to promote the cyclization for less electron-rich anilines.

Facile synthesis of acridine derivatives by ZnCl2-promoted intramolecular cyclization of o -arylaminophenyl schiff bases

A concise and efficient method for the synthesis of a wide range of acridine derivatives and polycyclic aza-aromatic compounds from a ZnCl 2-promoted cyclization reaction of readily available o-arylaminophenyl Schiff base compounds under convenient conditions was developed. Reaction conditions and scope of the new method were examined in detail.

Facile synthesis of unsymmetrical acridines and phenazines by a Rh(III)-catalyzed amination/cyclization/aromatization cascade

We report formal [3 + 3] annulations of aromatic azides with aromatic imines and azobenzenes to give acridines and phenazines, respectively. These transformations proceed through a cascade process of Rh(III)-catalyzed amination followed by intramolecular electrophilic aromatic substitution and aromatization. Acridines can be directly prepared from aromatic aldehydes by in situ imine formation using catalytic benzylamine.