2-(Dimethylamino)nicotinaldehyde

Base Information

• Chemical Name: 2-(Dimethylamino)nicotinaldehyde
• CAS No.: 35567-32-9
• Molecular Formula: C8H10 N2 O
• Molecular Weight: 150.18
• Hs Code.: 2933399090
• European Community (EC) Number: 819-568-3
• DSSTox Substance ID: DTXSID30424558
• Mol file: 35567-32-9.mol

Synonyms:2-(Dimethylamino)nicotinaldehyde;35567-32-9;2-(dimethylamino)pyridine-3-carbaldehyde;3-Pyridinecarboxaldehyde, 2-(dimethylamino)-;SCHEMBL12253115;DTXSID30424558;VVVIFWBMZJTEDQ-UHFFFAOYSA-N;MFCD07381372;AKOS005073209;KB-0752;SB52462;2-(dimethylamino)-3-pyridinecarboxaldehyde;2-(dimethylamino)nicotinaldehyde, AldrichCPR;3-Pyridinecarboxaldehyde,2-(dimethylamino)-;CS-0091282;D75071;EN300-213399;Z1201624113

Chemical Property of 2-(Dimethylamino)nicotinaldehyde

Chemical Property:

• PSA: 33.20000
• LogP: 0.96010
• XLogP3: 0.8
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 150.079312947
• Heavy Atom Count: 11
• Complexity: 136

Purity/Quality:

98%min ^*data from raw suppliers

2-(Dimethylamino)pyridine-3-carbaldehyde ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CN(C)C1=C(C=CC=N1)C=O
• Uses: 2-(Dimethylamino)pyridine-3-carbaldehyde

Technology Process of 2-(Dimethylamino)nicotinaldehyde

There total 3 articles about 2-(Dimethylamino)nicotinaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

2-chloro-3-carbaldehydepyridine (36404-88-3) + N,N-dimethyl-formamide (68-12-2,33513-42-7) → 2-(dimethylamino)pyridine-3-carbaldehyde (35567-32-9)

Guidance literature:

at 180 ℃; for 0.25h; Microwave irradiation;

DOI:10.1080/00397911.2010.515360

Reference yield: 75.0%

2-chloro-3-carbaldehydepyridine (36404-88-3) + dimethyl amine (124-40-3) → 2-(dimethylamino)pyridine-3-carbaldehyde (35567-32-9)

Guidance literature:

In methanol; water; at 55 ℃; for 48h;

Reference yield:

2-fluoropyridine-3-carboxaldehyde (36404-90-7) + dimethyl amine (124-40-3) → 2-(dimethylamino)pyridine-3-carbaldehyde (35567-32-9)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; Reflux;

DOI:10.1039/c6cc03600g

upstream raw materials:

2-chloro-3-carbaldehydepyridine

N,N-dimethyl-formamide

2-fluoropyridine-3-carboxaldehyde

dimethyl amine

Refernces

• 1、 -. "Substituted Pyrrolidines and Methods of Use". Paragraph 1538. . Retrieved 2018/04/20.
• 2、 Samadi, Abdelouahid,Silva, Daniel,Chioua, Mourad,Carreiras, Maria Do Carmo,Marco-Contelles, Jose. "Microwave irradiation-assisted amination of 2-chloropyridine derivatives with amide solvents". experimental part. p. 2859 - 2869. Retrieved 2011/09/12.