3568-81-8Relevant academic research and scientific papers
Fate of the anthelmintic, phenothiazine, in man
Mitchell,Kestell,Steventon,Waring
, p. 771 - 782 (2002)
1. Radiolabelled [35S]-phenothiazine has been administered orally to two healthy adult male volunteers (6 mg kg-1 body weight). Faeces were the major route of excretion of radioactivity (68%), the remainder being eliminated via the urine (32%) with an estimated urinary half-life (biphasic) of 6-16 h. Over the 5 days of the study a complete recovery of radioactivity was achieved. 2. From urinary data, it was shown that metabolism occurred via ring carbon oxidation to form phenothiazone and thionol and via ring sulphur oxidation to form phenothiazine sulphoxide. The majority of urinary material (92%) was present in the form of conjugates of phenothiazine and phenothiazone. Only unchanged phenothiazine was detected in the faeces. Phenothiazine sulphoxide was reduced to phenothiazine during incubation with faecal homogenates.
Boronate ester cross-linked PVA hydrogels for the capture and H2O2-mediated release of active fluorophores
Williams, George T.,Sedgwick, Adam C.,Sen, Sajal,Gwynne, Lauren,Gardiner, Jordan E.,Brewster, James T.,Hiscock, Jennifer R.,James, Tony D.,Jenkins, A. Toby A.,Sessler, Jonathan L.
, p. 5516 - 5519 (2020/06/10)
A new set of PVA hydrogels were formed using the boronate ester fluorescent probe PF1 and the novel boronate fluorescent probe PT1 as the covalent crosslinkers. Treatment with aqueous H2O2 allowed triggered release of the fluorescent dye accompanied by complete dissolution of the hydrogel.
