43035-11-6Relevant articles and documents
Molecular probe derived from calcium-sensitive receptor protein antagonist and application of molecular probe in parathyroid gland resection surgery
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Paragraph 0048; 0072-0074, (2021/07/28)
The invention discloses a molecular probe derived from a calcium-sensitive receptor protein antagonist and application of the molecular probe in parathyroid gland resection surgery. The molecular probe is specifically a molecular probe which is derived fr
A preparation method of methylene blue
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Paragraph 0015; 0027; 0047; 0061; 0062; 0072; 0073; 0083, (2018/04/02)
The invention discloses a preparation method of methylene blue, and belongs to the technical field of intermediate synthesis in fine chemical engineering. The preparation method comprises the following steps: in a condensed hydrochloric acid solution, carrying out nitrosation reactions between sodium nitrite and N,N-dimethylaniline so as to obtain an intermediate namely p-nitroso-N,N-dimethylaniline; subjecting p-nitroso-N,N-dimethylaniline to hydrogenation reduction to prepare p-amino-N,N-dimethylaniline; oxidizing p-amino-N,N-dimethylaniline, then adding sodium thiosulfate to carry out addition reactions to prepare 2-amino-5-dimethylaminophenyl thiosulfonic acid, adding N,N-dimethylaniline into 2-amino-5-dimethylaminophenyl thiosulfonic acid to carry out oxidative condensation reactions to generate bis(4-dimethylaminophenyl) thiosulfonic acid; and making bis(4-dimethylaminophenyl) thiosulfonic acid carry out ring-closing reactions to obtain methylene blue. The provided preparation method has the advantages of high product purity, simple technology flow, low manufacture cost, suitability for industrial production, easily-available raw materials, and little pollution to the environment.
Phenothiazinium photosensitisers XI. Improved toluidine blue photoantimicrobials
Wainwright, Mark,O'Kane, Ciara,Rawthore, Sophie
, p. 68 - 71 (2016/05/19)
The phenothiazinium derivative toluidine blue O (TBO) is widely employed as a photoantimicrobial agent in clinical trialling, particularly in dentistry. However, its activity against a range of pathogenic microbial species is not significantly different t