43035-11-6

Upstream product

• 99-98-9 4-amino-N,N-dimethylaniline 
• 7732-18-5 water 
• 64-19-7 acetic acid 
• 7664-93-9 sulfuric acid 
• 2836-03-5 N,N-dimethyl-1,2-phenylenediamine 
• 121-69-7 N,N-dimethyl-aniline 
• 536-47-0 N,N-dimethyl-1,4-phenylenediamine sulfate 
• 57842-97-4 N,N-dimethyl-p-phenylenediamine,radical ion[1+]; bromide 
• 138-89-6 p-dimethylaminonitrosobenzene 

Downstream Products

• 101632-41-1 {2-[4-(2-diethylamino-ethoxy)-phenyl]-benzothiazol-6-yl}-dimethyl-amine 
• 104037-03-8 2-Aethyl-6-dimethylamino-benzthiazol 
• 90872-47-2 2-Methylamino-6-dimethylamino-benzothiazol 
• 7664-93-9 sulfuric acid 
• 7782-99-2 sulphurous acid 
• 3568-81-8 thionol 
• 2516-05-4 methylene violet 
• 152071-32-4 methylene blue 
• 26283-09-0 methylene Blue; zinc chloride-double salt 
• 15967-15-4 (4-(2-(thiosulfate)-4-(dimethylamino)-phenylimino)-cyclohex-2,5-dienylidene)-N,N-dimethyl ammonium 
• 10205-77-3 [2-(4-dimethylamino-phenyl)-benzothiazol-6-yl]-dimethyl-amine 
• 10205-73-9 6-dimethylamino-2-phenylbenzothiazole 
• 43036-43-7 2-amino-5-dimethylamino-phenyl mercaptan 
• 2941-73-3 6-(N,N-dimethylamino)-2-methylbenzothiazole 

Relevant academic research and scientific papers

Molecular probe derived from calcium-sensitive receptor protein antagonist and application of molecular probe in parathyroid gland resection surgery

The invention discloses a molecular probe derived from a calcium-sensitive receptor protein antagonist and application of the molecular probe in parathyroid gland resection surgery. The molecular probe is specifically a molecular probe which is derived fr

Preparation method of methylene blue hapten and methylene blue immunogen

The invention relates to the technical field of medicines, and provides a preparation method of methylene blue hapten and immunogen. The preparation method comprises the following steps: carrying outchemical reaction on N, N-dimethyl p-phenylenediamine, a

A preparation method of methylene blue

The invention discloses a preparation method of methylene blue, and belongs to the technical field of intermediate synthesis in fine chemical engineering. The preparation method comprises the following steps: in a condensed hydrochloric acid solution, carrying out nitrosation reactions between sodium nitrite and N,N-dimethylaniline so as to obtain an intermediate namely p-nitroso-N,N-dimethylaniline; subjecting p-nitroso-N,N-dimethylaniline to hydrogenation reduction to prepare p-amino-N,N-dimethylaniline; oxidizing p-amino-N,N-dimethylaniline, then adding sodium thiosulfate to carry out addition reactions to prepare 2-amino-5-dimethylaminophenyl thiosulfonic acid, adding N,N-dimethylaniline into 2-amino-5-dimethylaminophenyl thiosulfonic acid to carry out oxidative condensation reactions to generate bis(4-dimethylaminophenyl) thiosulfonic acid; and making bis(4-dimethylaminophenyl) thiosulfonic acid carry out ring-closing reactions to obtain methylene blue. The provided preparation method has the advantages of high product purity, simple technology flow, low manufacture cost, suitability for industrial production, easily-available raw materials, and little pollution to the environment.

SYNTHESIS OF A THIOSULFONIC ACID BY A STEP OF PERIODATE MEDIATED OXIDATIVE COUPLING OF A THIOSULFONIC ACID WITH AN ANILINE

The present invention pertains generally to the field of chemical synthesis, and more particularly to methods for the chemical synthesis of a thiosulfonic acid of Formula (1) by a step of periodate mediated oxidative coupling of a thiosulfonic acid of For

Phenothiazinium photosensitisers XI. Improved toluidine blue photoantimicrobials

The phenothiazinium derivative toluidine blue O (TBO) is widely employed as a photoantimicrobial agent in clinical trialling, particularly in dentistry. However, its activity against a range of pathogenic microbial species is not significantly different t

METHODS OF CHEMICAL SYNTHESIS OF DIAMINOPHENOTHIAZINIUM COMPOUNDS INCLUDING METHYLTHIONINIUM CHLORIDE (MTC)

Methods of synthesizing and purifying certain 3,7-diamino-phenothiazin-5-ium compounds (referred to herein as "diaminophenothiazinium compounds") including Methythioninium Chloride (MTC) (also known as Methylene Blue) are provided.

TOLUIDINE BLUE DERIVATIVES AS PHOTOSENSITISING COMPOUNDS

A compound of formula (III), or a pharmaceutically acceptable derivative thereof for use in a method of combating and/or detecting a pathogen and/or tumour cells; wherein X is selected from O, S and Se; each of R2, R3 and R4 /s

TOLUIDINE BLUE DERIVATIVES AS PHOTOSENSITISING COMPOUNDS

A compound of formula (III), or a pharmaceutically acceptable derivative thereof for use in a method of combating and/or detecting a pathogen and/or tumour cells; wherein X is selected from O, S and Se; each of R2, R3 and R4 is independently selected from hydrogen or an optionally substituted alkyl, alkenyl, alkynyl or aryl group; and R1 is selected from halogen, sulfo, acyl, sulfoxy, mercapto, nitro, amino, hydroxy or an optionally substituted alkyl, alkenyl, alkynyl, aryl, amine or alkoxy group; wherein R1 is not methyl or hydrogen when each of R3 and R4 is methyl or hydrogen.

COMPOUNDS AND METHODS RELATING THERETO

A compound of formula (II) or a pharmaceutically acceptable derivative thereof for use in a method of combating and/or detecting a pathogen; wherein X is selected from O, S and Se; each of R1, R2, R4, R6, R8, R9, R11, R12, R13 and R14 is independently selected from hydrogen, halogen, sulfo, sulfoxy, mercapto, acyl, nitro, amino or an optionally substituted alkyl, alkenyl, alkynyl, aryl, amine or alkoxy group; provided that at least one of R11, R12, R13 and R14 is an optionally substituted amine group.

METHODS OF CHEMICAL SYNTHESIS OF DIAMINOPHENOTHIAZINIUM COMPOUNDS INVOLVING THE USE OF PERSULFATE OXIDANTS

This invention pertains generally to the field of chemical synthesis and purification, and more specifically to methods of synthesizing and purifying certain 3,7-diamino- phenothiazin-5-ium compounds (referred to herein as "diaminophenothiazinium compound