35729-40-9Relevant academic research and scientific papers
Bifunctional chiral selenium-containing 1,4-diarylazetidin-2-ones with potent antitumor activities by disrupting tubulin polymerization and inducing reactive oxygen species production
Tang, Hairong,Liang, Yuru,Cheng, Jiayi,Ding, Kuiling,Wang, Yang
, (2021/05/29)
Organoselenium compounds have attracted growing interests as promising antitumor agents over recent years. Herein, four series of novel selenium-containing chiral 1,4-diarylazetidin-2-ones were asymmetrically synthesized and biologically evaluated for ant
Sulfur and selenium derivatives of quinazoline and pyrido[2,3-d]pyrimidine: Synthesis and study of their potential cytotoxic activity in vitro
Moreno, Esther,Plano, Daniel,Lamberto, Iranzu,Font, María,Encío, Ignacio,Palop, Juan Antonio,Sanmartín, Carmen
experimental part, p. 283 - 298 (2012/02/16)
The synthesis, cytotoxic activities and selectivities of 35 derivatives related to quinazoline and pyrido[2,3-d]pyrimidine are described. The synthesized compounds were screened in vitro against four tumoral cell lines - leukemia (CCRF-CEM), colon (HT-29), lung (HTB-54) and breast (MCF-7) - and two cell lines derived from non-malignant cell lines, one mammary (184B5) and one from bronchial epithelium (BEAS-2B). MCF-7 and HTB-54 were the most sensitive cell lines with GI50 values below 10 μM for eleven and ten compounds, respectively. Two compounds (2o and 3a) were identified that evoked a marked cytotoxic effect in all cell lines tested and one compound, 7h, was potent and selective against MCF-7. A preliminary study into the mechanism of the potent derivatives 2o, 3a and 7h indicated that the cytotoxic activities of these compounds might be mediated by inducing cell death without affecting cell cycle phases.
Porphyrin architectures constructed by CH...π interactions: Synthesis and crystal structures of 5,10,15,20-tetrakis(4-methylchalcogenophenyl)-21H,23H-porphyrins
Sugiura, Ken-Ichi,Ushiroda, Kantaro,Tanaka, Takanori,Sawada, Masami,Sakata, Yoshiteru
, p. 927 - 928 (2007/10/03)
Tetraphenylporphyrins substituted with methylchalcogeno groups (XMe: X = Te, Se, S, and O) were prepared. Crystal structure analysis revealed that a novel type of molecular alignments was achieved by intermolecular CH...π interactions between XCH3 and porphyrin π-systems.
