35811-93-9Relevant articles and documents
Two-Step Synthesis of 3,4-Dihydropyrrolopyrazinones from Ketones and Piperazin-2-ones
Sandoval, Cosme,Lim, Ngiap-Kie,Zhang, Haiming
, p. 1252 - 1255 (2018/02/22)
An expedient two-step synthesis of 3,4-dihydropyrrolopyrazinones has been achieved via a Vilsmeier-Haack reaction of ketones, followed by an annulation of the corresponding chloroaldehydes with commercially available piperazin-2-ones. A variety of cyclic and acyclic ketones and piperazin-2-ones participated in this two-step chemistry, affording the desired 3,4-dihydropyrrolopyrazinones in up to 78% yield.
A general and efficient approach to 2H-indazoles and 1H-pyrazoles through copper-catalyzed intramolecular N-N bond formation under mild conditions
Hu, Jiantao,Cheng, Yongfeng,Yang, Yiqing,Rao, Yu
supporting information; experimental part, p. 10133 - 10135 (2011/10/09)
A new efficient copper-catalyzed intramolecular amination reaction has been developed to readily synthesise a wide variety of multi-substituted 2H-indazole and 1H-pyrazole derivatives from easily accessible starting materials under mild conditions. A highly selective ligand for estrogen receptor β was prepared in three steps by employing this method. The Royal Society of Chemistry 2011.
Synthesis of new thieno[b]azepinediones from α-methylene ketones
Migianu, Evelyne,Kirsch, Gilbert
, p. 1096 - 1100 (2007/10/03)
New substituted 6,7-dihydro-4H-thieno[3,2-b]azepine-5,8-diones were synthesized in seven steps, starting from substituted α-methylene ketones, via 3-aminothiophene-2-carboxylic acid alkyl esters.