35909-01-4

Basic information

• Product Name: L-Proline, 1-nitroso-, methyl ester (9CI)
• Synonyms: L-Proline, 1-nitroso-, methyl ester (9CI)
• CAS NO: 35909-01-4
• Molecular Formula: C₆H₁₀N₂O₃
• Molecular Weight: 158.1552
• Product Categories: PYRROLE
• Mol File: 35909-01-4.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 279.5°Cat760mmHg
• Flash Point: 122.8°C
• Appearance: /
• Density: 1.36g/cm³
• Vapor Pressure: 0.004mmHg at 25°C
• Refractive Index: 1.559
• CAS DataBase Reference: L-Proline, 1-nitroso-, methyl ester (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: L-Proline, 1-nitroso-, methyl ester (9CI)(35909-01-4)
• EPA Substance Registry System: L-Proline, 1-nitroso-, methyl ester (9CI)(35909-01-4)

Safety Data

• Hazardous Substances Data: 35909-01-4(Hazardous Substances Data)

Usage

InChI:InChI=1/C6H10N2O3/c1-11-6(9)5-3-2-4-8(5)7-10/h5H,2-4H2,1H3/t5-/m0/s1

Upstream product

• 220060-08-2 (R)-2-methylpyrrolidine-2-carboxylic acid methyl ester hydrochloride 
• 104-15-4 toluene-4-sulfonic acid 
• 147-85-3 L-proline 
• 2133-40-6 L-proline methyl ester monohydrochloride 
• 2577-48-2 methyl (2S)-pyrrolidine carboxylate 
• 67-56-1 methanol 
• 7519-36-0 nitrosoproline 

Downstream Products

• 604003-91-0 (S)-1-aminopyrrolidine-2-carboxylic acid methyl ester 

Relevant articles and documents

Prolinimines: N-Amino- l -Pro-methyl Ester (Hydrazine) Schiff Bases from a Fish Gastrointestinal Tract-Derived Fungus, Trichoderma sp. CMB-F563

A rice cultivation of a fish gastrointestinal tract-derived fungus, Trichoderma sp. CMB-F563, yielded natural products incorporating a rare hydrazine moiety, embedded within a Schiff base. Structures inclusive of absolute configurations were assigned to prolinimines A-D (1-4) on the basis of detailed spectroscopic and C3 Marfey's analysis, as well as biosynthetic considerations, biomimetic total synthesis, and chemical transformations. Of note, monomeric 1 proved to be acid labile and, during isolation, underwent quantitative transformation to dimeric 3 and trimeric 4. Prolinimines are only the second reported natural products incorporating an N-amino-Pro residue, the first to include l-Pro, the first to occur as Schiff bases, and the first to be isolated from a microorganism.

DIHYDROPYRIDAZINE-3,5-DIONE DERIVATIVE AND PHARMACEUTICALS CONTAINING THE SAME

The present invention provides a dihydropyridazine-3,5-dione derivative or a salt thereof, or a solvate of the compound or the salt, a pharmaceutical drug, a pharmaceutical composition, a sodium-dependent phosphate transporter inhibitor, and a preventive and/or therapeutic agent for hyperphosphatemia, secondary hyperparathyroidism, chronic renal failure, chronic kidney disease, and arteriosclerosis associated with vascular calcification comprising the compound as an active ingredient, and a method for prevention and/or treatment.

Diversity-oriented synthesis of a drug-like system displaying the distinctive N→C=O interaction

(Chemical Equation Presented) This study describes the syntheses and characterization of two hydrazino ureas. These fold into a six-membered ring by virtue of the infrequently observed δ+N→C=O δ- interaction when solvated by polar pr