35973-14-9

Usage

Uses

Used in Pharmaceutical Industry:
6-Chloro-4-hydroxyquinoline-3-carboxylic acid is used as a pharmaceutical intermediate for the development of new therapeutic agents, leveraging its potential biological activities and reactivity.
Used in Antibacterial Applications:
In the field of microbiology, 6-CHLORO-4-HYDROXYQUINOLINE-3-CARBOXYLIC ACID is used as an antibacterial agent, targeting a range of bacterial pathogens due to its ability to interfere with their metabolic processes.
Used in Antifungal Applications:
6-CHLORO-4-HYDROXYQUINOLINE-3-CARBOXYLIC ACID is also utilized as an antifungal agent, effective against various fungal species, thereby offering potential in treating fungal infections.
Used in Chelating Agent Applications:
6-CHLORO-4-HYDROXYQUINOLINE-3-CARBOXYLIC ACID is used as a chelating agent in chemical research and industrial processes, particularly for metal ion sequestration and the inhibition of metalloenzymes, which can be beneficial in various chemical and environmental applications.
Used in Metalloenzyme Inhibition:
In the field of biochemistry, 6-CHLORO-4-HYDROXYQUINOLINE-3-CARBOXYLIC ACID is used to inhibit metalloenzymes, which can be crucial in understanding enzyme function and developing enzyme-targeted therapies.

InChI:InChI=1/C10H6ClNO3/c11-5-1-2-8-6(3-5)9(13)7(4-12-8)10(14)15/h1-4H,(H,12,13)(H,14,15)

Upstream product

• 70271-77-1 6-chloro-4-hydroxyquinoline-3-carboxylic acid ethyl ester 
• 105-53-3 diethyl malonate 
• 2032-24-8 N,N'-di(p-chlorophenyl)formamidine 
• 106-47-8 4-chloro-aniline 
• 19056-79-2 diethyl 4-chloroanilinomethylenemalonate 

Downstream Products

• 41957-78-2 9-chloro-3-cyclohexyl-2-cyclohexylimino-2,3-dihydro-[1,3]oxazino[5,6-c]quinolin-4-one 
• 4203-18-3 4,6-dichloroquinoline 
• 23432-43-1 6-chloro-4-hydroxyquinoline 
• 24337-70-0 4-anilino-6-chloroquinoline-3-carboxylic acid 

Relevant academic research and scientific papers

PAPD5 INHIBITORS AND METHODS OF USE THEREOF

The present application provides compounds that are PAPD5 inhibitors and are useful in treating a variety of conditions such as cancer, telomere diseases, and aging-related and other degenerative disorders.

Design, synthesis, and biological evaluation of novel quinoline derivatives as HIV-1 Tat-TAR interaction inhibitors

Thirty-two quinoline derivatives were designed and synthesized as HIV-1 Tat-TAR interaction inhibitors. All the compounds showed high antiviral activities in inhibiting the formation of SIV-induced syncytium in CEM174 cells. Nine of them with low cytotoxicities were evaluated by Tat dependent HIV-1 LTR-driven CAT gene expression colorimetric enzyme assay in human 293T cells, indicating effective inhibitory activities of blocking the Tat-TAR interaction. Molecular modeling experiments indicated that these compounds may inhibit Tat-TAR interaction by binding to Tat protein instead of TAR RNA.

Antimalarials: Synthesis of 4-aminoquinolines that circumvent drug resistance in malaria parasites

The strategies described here have permitted the synthesis of a series of 4-aminoquinoline antimalarials. Substantive improvements over previous syntheses include nucleophilic substitution with neat amine rather than in phenol, regioselective reductive alkylation to convert the terminal primary amine (12a-20a) on the diaminoalkane side chain to a diethylamino group, and purification by column chromatography with basic alumina. The 1H nmr spectra obtained after regioselective reductive alkylation with sodium borodeuteride (in comparison with sodium borohydride) demonstrated that this reductive alkylation proceeds via formation and subsequent reduction of the corresponding diamides in situ.

4-HYDROXY-2-QUINOLONES. 20. SYNTHESIS AND CHEMICAL CONVERSIONS OF ETHYL ESTERS OF CHLORO-SUBSTITUTED QUINOLINE-3-CARBOXYLIC ACIDS

Preparative methods for the synthesis of ethyl esters of 2,4-dichloro- and 2-oxo-4-chloroquinoline-3-carboxylic acids were developed.The behavior of the compounds indicated was studied under conditions of alkaline and acidic hydrolysis, in reactions with some nucleophilic reagents, as well as in reductive dehalogenation.Results of the study of the antimicrobial and antiinflammatory activity of the synthesized compounds are presented.