35980-25-7

Basic information

• Product Name: AcetaMide, 2,2,2-trifluoro-N-(4-fluorophenyl)-
• Synonyms: AcetaMide, 2,2,2-trifluoro-N-(4-fluorophenyl)-;2,2,2-Trifluoro-N-(4-fluoro-phenyl)-acetamide
• CAS NO: 35980-25-7
• Molecular Formula: C₈H₅F₄NO
• Molecular Weight: 207.1250128
• Mol File: 35980-25-7.mol
• Article Data: 11

Chemical Properties

• Boiling Point: 241.4°C at 760 mmHg
• Flash Point: 99.8°C
• Appearance: /
• Density: 1.447g/cm³
• Vapor Pressure: 0.036mmHg at 25°C
• Refractive Index: 1.484
• CAS DataBase Reference: AcetaMide, 2,2,2-trifluoro-N-(4-fluorophenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: AcetaMide, 2,2,2-trifluoro-N-(4-fluorophenyl)-(35980-25-7)
• EPA Substance Registry System: AcetaMide, 2,2,2-trifluoro-N-(4-fluorophenyl)-(35980-25-7)

Safety Data

• Hazardous Substances Data: 35980-25-7(Hazardous Substances Data)

Usage

InChI:InChI=1/C8H5F4NO/c9-5-1-3-6(4-2-5)13-7(14)8(10,11)12/h1-4H,(H,13,14)

Upstream product

• 404-24-0 2,2,2-trifluoro-N-phenylacetamide 
• 371-40-4 4-fluoroaniline 
• 76-05-1 trifluoroacetic acid 
• 407-25-0 trifluoroacetic anhydride 
• 81290-20-2 (trifluoromethyl)trimethylsilane 
• 1195-45-5 para-fluorophenyl isocyanate 

Downstream Products

• 5083-03-4 4-methyl-N-(4-fluorophenyl)benzamide 
• 62158-94-5 4-fluoro-N-(2,2,2-trifluoroethyl)aniline 
• 75-89-8 2,2,2-trifluoroethanol 
• 371-40-4 4-fluoroaniline 
• 128691-95-2 N-(2-Amino-4-fluoro-phenyl)-2,2,2-trifluoro-acetamide 

Relevant articles and documents

Amination reagent as well as preparation method and application thereof

The invention discloses an amination reagent as well as a preparation method and application thereof. The amination reagent has a structure as shown in a formula disclosed in the invention, wherein Xis selected from any one of I, Cl, Br, NO3 and ClO4, and Y and Z are independently selected from H or alkyl with the carbon atom number of 1-4. The process for preparing the amination reagent is simple, the raw materials are easy to obtain, the cost is low, the yield is stable, and the prepared amination reagent is stable in character, can be stored at room temperature for a long time and can be taken as needed; meanwhile, the prepared amination reagent is efficient in performance, boron substrate applicability is excellent, reaction effect is good, and limitation of amination reaction of organic boron compounds on substrates is greatly expanded.

ACETAMIDO DERIVATIVES AS DNA POLYMERASE THETA INHIBITORS

Disclosed herein are certain acetamido derivatives that are DNA Polymerase Theta (Polθ) inhibitors of Formula (I). Also, disclosed are pharmaceutical compositions comprising such compounds and methods of treating diseases treatable by inhibition of Polθ such as cancer, including homologous recombination (HR) deficient cancers.

Hypervalent iodine mediated para -selective fluorination of anilides

A metal-free method for the direct regioselective fluorination of anilides has been developed. In the presence of bis(tert-butylcarbonyloxy)iodobenzene (PhI(OPiv)2) and hydrogen fluoride-pyridine, the para-fluorination products of anilides were obtained in moderate to good yields. Because of its operational safety and the use of readily available reagents, this new procedure provides facile access to a variety of para-fluorinated anilides.