359887-29-9Relevant academic research and scientific papers
Asymmetric Synthesis of α-Chloro-α-halo Ketones by Decarboxylative Chlorination of α-Halo-β-ketocarboxylic Acids
Iwasa, Seiji,Kitahara, Kazumasa,Mizutani, Haruna,Shibatomi, Kazutaka
supporting information, p. 4385 - 4392 (2019/11/21)
Chiral α-chloro-α-fluoro ketones were synthesized by enantio-selective decarboxylative chlorination of α-chloro-β-ketocarboxylic acids in the presence of a chiral amine catalyst. The reaction yielded the corresponding α-chloro-α-fluoro ketones with modera
Enantioselective and Diastereoselective Ir-Catalyzed Hydrogenation of α-Substituted β-Ketoesters via Dynamic Kinetic Resolution
Gu, Guoxian,Lu, Jiaxiang,Yu, Ouran,Wen, Jialin,Yin, Qin,Zhang, Xumu
supporting information, p. 1888 - 1892 (2018/04/16)
An iridium/f-amphol catalytic system for the enantioselective hydrogenation of α-substituted β-ketoesters via dynamic kinetic resolution is reported. The desired anti products were obtained in high yields (up to 98%) with good diastereoselectivity (up to 96:4 diastereometic ratio (dr)) and excellent enantioselectivity (up to >99% enantiomeric excess (ee)). A catalytic model is proposed to explain the stereoselectivity.
Method for preparing alpha-alkyl-beta-ketone ester compound
-
Paragraph 0104-0107, (2018/05/01)
The invention discloses a method for preparing an alpha-alkyl-beta-ketone ester compound shown as a formula (I). The method comprises the following steps: a 1,4-dihydropyridine ester compound shown asa formua (III) is taken as a reducing agent, and under existence of a Lewis acid catalyst, a compound in a formula (II) is subjected to a reduction reaction to obtain the alpha-alkyl-beta-ketone ester compound shown as the formula (I). The method has the advantages of simple operation, mild condition and environmental protection, and is suitable for a plurality of substrates, and the yield can reach as highest as 95%. By using the method of the invention, a plurality of alpha-alkyl-beta-ketone ester compounds can be efficiently prepared, types of medical intermediates are enriched, and the method has an excellent industrial application prospect.
Thiourea catalysed reduction of α-keto substituted acrylate compounds using Hantzsch ester as a reducing agent in water
Weng, Guanglin,Ma, Xiaobo,Fang, Dongmei,Tan, Ping,Wang, Lijiao,Yang, Linlin,Zhang, Yuanyuan,Qian, Shan,Wang, Zhouyu
, p. 22909 - 22912 (2017/07/10)
The first method for the reduction of α-keto substituted acrylate compounds by Hantzsch ester in water under the catalysis of thiourea has been developed. The products were isolated in moderate to high yields (38-95%). These products are important intermediates in the synthesis of a series of natural products and other biologically active molecules.
Simple preparation of α-diazo esters
Taber, Douglass F.,Sheth, Ritesh B.,Joshi, Pramod V.
, p. 2851 - 2854 (2007/10/03)
(Chemical Equation Presented) The TiCl4-mediated reaction of an ester with benzoyl chloride results in high yields of the α-benzoylated ester. Diazo transfer of the benzoylated ester utilizing p- acetoamidobenzenesulfonyl azide affords the α-diazo ester in good yield. Using this simplified procedure, it is easy to prepare gram quantities of α-diazo esters.
Arylation of α-substituted acrylates in ionic liquids catalyzed by a Pd-benzothiazole carbene complex
Calò, Vincenzo,Nacci, Angelo,Lopez, Luigi,Napola, Annalisa
, p. 4701 - 4703 (2007/10/03)
A Pd-catalyst with benzothiazole carbene as ligands allows, in tetrabutylammonium bromide melt as solvent, very fast and efficient reactions of bromoaromatics with 3-hydroxy-2-methylenealkanoates to give β-arylketones.
