359887-29-9

Upstream product

• 16537-10-3 tert-butyl 3-phenylpropanoate 
• 98-88-4 benzoyl chloride 
• 54441-66-6 tert-butyl benzoylacetate 
• 100-39-0 benzyl bromide 
• 5397-27-3 tert-butyl 3-hydroxy-3-phenylpropionate 
• 100-52-7 benzaldehyde 
• 540-88-5 acetic acid tert-butyl ester 
• 119515-83-2 tert-butyl 2-benzoyl-3-phenylacrylate 
• 108-86-1 bromobenzene 
• 135513-98-3 tert-butyl 2-(hydroxy(phenyl)methyl)acrylate 

Downstream Products

• 1155875-09-4 tert-butyl 2-benzyl-2-fluoro-3-oxo-3-phenylpropanoate 
• 850147-87-4 tert-butyl α-benzyl-α-diazoacetate 

Relevant academic research and scientific papers

Asymmetric Synthesis of α-Chloro-α-halo Ketones by Decarboxylative Chlorination of α-Halo-β-ketocarboxylic Acids

Chiral α-chloro-α-fluoro ketones were synthesized by enantio-selective decarboxylative chlorination of α-chloro-β-ketocarboxylic acids in the presence of a chiral amine catalyst. The reaction yielded the corresponding α-chloro-α-fluoro ketones with modera

Method for preparing alpha-alkyl-beta-ketone ester compound

The invention discloses a method for preparing an alpha-alkyl-beta-ketone ester compound shown as a formula (I). The method comprises the following steps: a 1,4-dihydropyridine ester compound shown asa formua (III) is taken as a reducing agent, and under existence of a Lewis acid catalyst, a compound in a formula (II) is subjected to a reduction reaction to obtain the alpha-alkyl-beta-ketone ester compound shown as the formula (I). The method has the advantages of simple operation, mild condition and environmental protection, and is suitable for a plurality of substrates, and the yield can reach as highest as 95%. By using the method of the invention, a plurality of alpha-alkyl-beta-ketone ester compounds can be efficiently prepared, types of medical intermediates are enriched, and the method has an excellent industrial application prospect.

Enantioselective and Diastereoselective Ir-Catalyzed Hydrogenation of α-Substituted β-Ketoesters via Dynamic Kinetic Resolution

An iridium/f-amphol catalytic system for the enantioselective hydrogenation of α-substituted β-ketoesters via dynamic kinetic resolution is reported. The desired anti products were obtained in high yields (up to 98%) with good diastereoselectivity (up to 96:4 diastereometic ratio (dr)) and excellent enantioselectivity (up to >99% enantiomeric excess (ee)). A catalytic model is proposed to explain the stereoselectivity.

Thiourea catalysed reduction of α-keto substituted acrylate compounds using Hantzsch ester as a reducing agent in water

The first method for the reduction of α-keto substituted acrylate compounds by Hantzsch ester in water under the catalysis of thiourea has been developed. The products were isolated in moderate to high yields (38-95%). These products are important intermediates in the synthesis of a series of natural products and other biologically active molecules.

Simple preparation of α-diazo esters

(Chemical Equation Presented) The TiCl4-mediated reaction of an ester with benzoyl chloride results in high yields of the α-benzoylated ester. Diazo transfer of the benzoylated ester utilizing p- acetoamidobenzenesulfonyl azide affords the α-diazo ester in good yield. Using this simplified procedure, it is easy to prepare gram quantities of α-diazo esters.

Arylation of α-substituted acrylates in ionic liquids catalyzed by a Pd-benzothiazole carbene complex

A Pd-catalyst with benzothiazole carbene as ligands allows, in tetrabutylammonium bromide melt as solvent, very fast and efficient reactions of bromoaromatics with 3-hydroxy-2-methylenealkanoates to give β-arylketones.