36076-26-3

Usage

Uses

Used in Pharmaceutical Industry:
1,4-Phenylenediacetic Acid Diethyl Ester is used as a key intermediate in the synthesis of potent β-3 receptor agonists. These agonists play a crucial role in the development of medications targeting conditions such as obesity, diabetes, and other metabolic disorders. 1,4-PHENYLENEDIACETIC ACID DIETHYL ESTER's ability to interact with β-3 receptors makes it a valuable component in the design and production of these therapeutic agents.

Upstream product

• 64-17-5 ethanol 
• 622-75-3 1,4-phenylenediacetonitrile 
• 105077-01-8 diethyl α-methylthio-1,4-benzenediacetate 
• 7325-46-4 1,4-phenylenediacetic acid 
• 101-97-3 Ethyl 2-phenylethanoate 
• 872-31-1 3-Bromothiophene 
• 105-53-3 diethyl malonate 
• 106-39-8 bromochlorobenzene 
• 624-38-4 para-diiodobenzene 
• 141-97-9 ethyl acetoacetate 

Downstream Products

• 109588-07-0 p-phenylenedi-acetic acid ethyl ester-(2-diethylamino-ethyl ester) 
• 7325-46-4 1,4-phenylenediacetic acid 
• 104183-09-7 benzenediethanol-1,1,1',1'-d4 
• 79815-73-9 p-phenylene-bis-(diethyl malonate) 
• 1244044-73-2 1,4-bis[2,2-bis(4-n-pentyloxyphenyl)vinyl]benzene 
• 1244044-72-1 1,4-bis[2,2-bis(4-ethoxyphenyl)vinyl]benzene 
• 1244044-80-1 1,4-bis[2,2-bis(4-hydroxyphenyl)vinyl]benzene 
• 1244044-77-6 1,4-bis[2,2-bis(4-i-propoxyphenyl)vinyl]benzene 
• 1244044-74-3 1,4-bis[2,2-bis(4-n-hexyloxyphenyl)vinyl]benzene 
• 1244044-76-5 1,4-bis[2,2-bis(4-n-nonyloxyphenyl)vinyl]benzene 
• 1244044-75-4 1,4-bis[2,2-bis(4-n-heptyloxyphenyl)vinyl]benzene 
• 113520-36-8 2-(4-(2-ethoxy-2-oxoethyl)phenyl)acetic acid 
• 101566-38-5 6-(2-hydroxyethyl)-2(3H)-indolone 
• 1044954-75-7 2,2'-(1,4-phenylene)dibutyric acid 

Relevant academic research and scientific papers

HETEROCYCLIC COMPOUNDS, PROCESS FOR PREPARATION OF THE SAME AND USE THEREOF

The present invention provides a heterocyclic compound represented by the formula (I), its stereoisomers, or a pharmaceutically acceptable salt thereof, pharmaceutical compositions thereof, and their use in preparing a medicament for the prevention and/or treatment of central nervous system disease.

Alcohol assisted C-C bond breaking: Copper-catalyzed deacetylative α-arylation of β-keto esters and amides

A method of alcohol-assisted copper-catalyzed highly selective deacetylative α-arylation of β-keto esters and amides has been demonstrated, which illustrated an efficient example of achieving α-aryl esters and amides. From the synthetic point of view, this arylation protocol is general and practical, representing a simple way to produce α-arylated carbonyl compounds from basic starting materials at low cost.

Practical synthesis of 2-arylacetic acid esters via palladium-catalyzed dealkoxycarbonylative coupling of malonates with aryl halides

A new palladium-based system was developed that catalyzes the coupling of aryl halides with diethyl malonates in the presence of mild bases. In the course of the reaction, the intermediately formed diethyl arylmalonate is directly converted into the arylacetic acid ester via liberation of carbon dioxide and an alkanol. This cross-coupling/dealkoxycarbonylation process provides an efficient and high-yielding synthetic entry to diversely functionalized arylacetic acid esters. Two complementary protocols were developed, one of which is optimal for electron-rich, the other for electron-poor aryl halides. Both make use of low loadings of palladium(0) bis(dibenzylideneacetone) (0.5 mol%)/tri-tert-butylphosphonium tetrafluoroborate (1.1 mol%) as the catalyst and diethyl malonate as the reaction solvent. The new procedures are particularly effective for sterically hindered substrates. Copyright

Synthesis of 1,4-bis[2,2-bis(4-alkoxyphenyl)vinyl]benzenes and side chain modulation of their solid-state emission

Figure Presented. A series of 1,4-bis[2,2-bis(4-alkoxyphenyl)vinyl]benzene molecules with aggregation-induced emission (AIE) activity were synthesized. The conformations and packing arrangements of these molecules in the solid state can be adjusted by changing the side chains, which subsequently modulates their solid-state emission. The fluorescence quantum yield of 1e with the n-C 6H13 side chain in the solid state could reach up to 60.3% in the solid state.

Synthesis of naphthalenes and 2-naphthols by the electrophilic cyclization of alkynes

A wide variety of substituted naphthalenes are readily prepared regioselectively under mild reaction conditions by the 6-endo-dig electrophilic cyclization of appropriate arene-containing propargylic alcohols by IC1, I 2, Br2, NBS, and PhSeBr. 3-Iodo-2-naphthols have also been prepared in excellent yields by the cyclization of analogous 1-aryl-3-alkyn-2-ones. This methodology readily accommodates various functional groups and has been successfully extended to the synthesis of substituted carbazoles and dibenzothiophenes.

Sulfonamide derivatives for the treatment of diseases

The invention relates to compounds of formula (1) and to processes for the preparation of, intermediates used in the preparation of, compositions containing and the uses of, such derivatives. The compounds according to the present invention are useful in numerous diseases, disorders and conditions, in particular inflammatory, allergic and respiratory diseases, disorders and conditions.

Syntheses of Arenediacetic Esters and Acetonyl-Substituted Arylacetic Esters by Means of Friedel-Crafts Reaction with α-Acyl-α-chlorosulfides

Friedel-Crafts reaction of the phenylacetates 5a, b with ethyl α-chloro-α-(methylthio)acetate (1) in the presence of stannic chloride gave the α-methylthio-1,4-benzenediacetates 7a, b.The reactions of biphenyl, diphenylmethane, and diphenyl ether with an excess amount of 1 gave directly the corresponding disubstituted products 10a-c.Desulfurization of 7a, b and 10a-c gave the corresponding diacetates 8a, b and 11a-c.Methyl 4-(2-oxopropyl)phenylacetate (14) was prepared by reaction of methyl phenylacetate with α-chloro-α-(methylthio)acetone (2) followed by desulfurization of the resulting product.Methyl 2-(2-furyl)propionate (19) reacted with 2 in the presence of zinc chloride to give the 2,5-disubstituted furan 20, whose desulfurization gave methyl 2-propionate (21).Keywords - arenediacetic ester; Friedel-Crafts reaction; α-chlorosulfide; nonactic acid; nonactin; desulfurization; Raney nickel; stannic chloride; zinc chloride