3609-87-8

Basic information

• Product Name: N-BENZYL 4-BROMOBENZENESULFONAMIDE
• Synonyms: N-BENZYL 4-BROMOBENZENESULFONAMIDE;N-BENZYL-4-BROMOBENZENESULPHONAMIDE;N-Benzyl-4-bromobenzenesulphonamide 98%;N-Benzyl-4-bromobenzenesulphonamide98%
• CAS NO: 3609-87-8
• Molecular Formula: C₁₃H₁₂BrNO₂S
• Molecular Weight: 326.21
• Product Categories: blocks;Bromides;Sulfonamides
• Mol File: 3609-87-8.mol
• Article Data: 20

Chemical Properties

• Melting Point: 102-104
• Boiling Point: 447.4 °C at 760 mmHg
• Flash Point: 224.4 °C
• Appearance: /
• Density: 1.503 g/cm³
• Vapor Pressure: 3.39E-08mmHg at 25°C
• Refractive Index: 1.62
• CAS DataBase Reference: N-BENZYL 4-BROMOBENZENESULFONAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: N-BENZYL 4-BROMOBENZENESULFONAMIDE(3609-87-8)
• EPA Substance Registry System: N-BENZYL 4-BROMOBENZENESULFONAMIDE(3609-87-8)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 3609-87-8(Hazardous Substances Data)

Usage

General Description

N-Benzyl 4-bromobenzenesulfonamide is a chemical compound with the molecular formula C14H12BrNO2S. It is a sulfonamide derivative with a benzyl group attached to the nitrogen atom. N-BENZYL 4-BROMOBENZENESULFONAMIDE is commonly used as a reagent in organic chemistry for the synthesis of various pharmaceutical and agrochemical products. It is also known for its potential antibacterial and antifungal properties, making it a valuable compound in the development of new drugs. Additionally, N-benzyl 4-bromobenzenesulfonamide has been studied for its potential use in the treatment of various medical conditions, making it an important compound in the field of medicinal chemistry.

InChI:InChI=1/C13H12BrNO2S/c14-12-6-8-13(9-7-12)18(16,17)15-10-11-4-2-1-3-5-11/h1-9,15H,10H2

Upstream product

• 100-46-9 benzylamine 
• 98-58-8 4-bromobenzenesulfonyl chloride 
• 20846-02-0 4-bromo-benzenesulfonic acid ethyl ester 
• 701-34-8 4-bromo-benzenesulfonic acid amide 
• 100-51-6 benzyl alcohol 
• 108-88-3 toluene 
• 100-52-7 benzaldehyde 

Downstream Products

• 170948-01-3 C₁₈H₂₀BrNO₄S 
• 56768-47-9 Ν-benzyl-4-cyanobenzenesulfonamide 
• 14674-31-8 N-(p-bromobenzenesulfonyl)benzenealdimine 

Relevant articles and documents

Copper-boryl mediated transfer hydrogenation of N-sulfonyl imines using methanol as the hydrogen donor

B2Pin2-assisted copper-catalyzed transfer hydrogenation of aromatic sulfonylimines has been achieved, delivering a variety of aryl/heteroaryl sulfonamides in good to excellent yields under mild reaction conditions and with methanol a

Method for synthesizing N-alkyl sulfonamide in water

The invention discloses a method for synthesizing N-alkyl sulfonamide in water, in particular to a method for synthesizing an N-alkyl sulfonamide derivative from a sulfonamide derivative and alcohol,and a water-soluble iridium complex is adopted to catalyze the reaction of N-alkyl sulfonamide. Compared with the previous synthesis method, the method has the advantages that a reaction equivalent substrate is used in the reaction process, so that raw material waste is avoided; weak base is used, and reaction conditions are mild; non-toxic and harmless pure water is used as a solvent in the reaction, only water is generated as a by-product, the atom reaction economy is high, and the requirement of green chemistry is met.

The: N -alkylation of sulfonamides with alcohols in water catalyzed by a water-soluble metal-ligand bifunctional iridium complex [Cp?Ir(biimH2)(H2O)][OTf]2

The iridium complex [Cp?Ir(biimH2)(H2O)][OTf]2 (Cp? = η5-pentamethylcyclopentadienyl, biimH2 = 2,2′-biimidazole) was synthesized and developed as a new-type of water-soluble metal-ligand bifunctional catalyst for the N-alkylation of poorly nucleophilic sulfonamides with alcohols in water. In the presence of catalyst (1 mol%) and Cs2CO3 (0.1 equiv.), a series of desirable products was obtained in 74-91% yields under microwave irradiation. Mechanistic experiments revealed that the presence of NH units in the imidazole ligand is crucially important for the catalytic activity of the iridium complex. Notably, this research would facilitate the process of water-soluble metal-ligand bifunctional catalysis for the hydrogen autotransfer process.