36273-77-5

Upstream product

• 36273-76-4 6β-(4-nitro-benzylideneamino)-penicillanic acid benzyl ester 
• 74-88-4 methyl iodide 
• 49626-56-4 6α-(4-nitro-benzylideneamino)-penicillanic acid benzyl ester 
• 36273-76-4 6ξ-(4-nitro-benzylideneamino)-penicillanic acid benzyl ester 
• 49626-61-1 benzyl (4S)-4,5-dihydro-5,5-dimethylthiazole-4-carboxylate 
• 49626-59-7 D-penicillamine benzyl ester 
• 555-16-8 4-nitrobenzaldehdye 
• 49626-54-2 benzyl (2S,5R,6S)-6-amino-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate 
• 49626-62-2 6α-azido-penicillanic acid benzyl ester 
• 100-39-0 benzyl bromide 
• 551-16-6 6-Aminopenicillanic Acid 
• 3956-31-8 benzyl (2S,5R,6R)-6-amino-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate 

Downstream Products

• 36273-79-7 (5R)-3,3,6c-trimethyl-7-oxo-6t-(2-phenyl-acetylamino)-(5rH)-4-thia-1-aza-bicyclo[3.2.0]heptane-2c-carboxylic acid benzyl ester 
• 40400-91-7 (5R)-3,3,6c-trimethyl-7-oxo-6t-(2-phenyl-acetylamino)-(5rH)-4-thia-1-aza-bicyclo[3.2.0]heptane-2c-carboxylic acid 
• 388568-32-9 (2S,5R,6R)-3,3,6-Trimethyl-6-[(R)-5-(4-nitro-benzyloxycarbonyl)-5-(4-nitro-benzyloxycarbonylamino)-pentanoylamino]-7-oxo-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid benzyl ester 
• 36273-78-6 (5R)-6t-amino-3,3,6c-trimethyl-7-oxo-(5rH)-4-thia-1-aza-bicyclo[3.2.0]heptane-2c-carboxylic acid benzyl ester 

Relevant academic research and scientific papers

Contrasting fates for 6-α-methylpenicillin N upon oxidation by deacetoxycephalosporin C synthase (DAOCS) and deacetoxy/deacetylcephalosporin C synthase (DAOC/DACS)

6-α-Methylpenicillin N was synthesised via known routes from 6-aminopenicillanic acid, and tested as a substrate for recombinant DAOCS and DAOC/DACS. Incubation with DAOCS resulted in conversion of 2-oxoglutarate without oxidation of the penicillin substrate ('uncoupled turnover'). Incubation with DAOC/DACS resulted in oxidation to the cephem aldehyde. This is the first example of substrate-induced 'uncoupled turnover', which has been proposed to be an editing mechanism for these enzymes. Elsevier Science Ltd. All rights reserved.

7-(or 6-) Substituted-7-(or 6-)acylimino cephalosporin (or penicillin) compounds

A process is provided which yields derivatives of cephalosporins and penicillins. The process starts with 7-aminodecephalosporanic acid or 6-APA and reacts with a carbonyl containing compound to form a Schiff's base (imino) adduct. This latter compound is