49626-54-2Relevant articles and documents
Visible-light-mediated dehydrogenative cross-coupling between terminal alkynes and aldehydes by employing a supramolecular polymeric ensemble of PBI derivative
Kataria, Meenal,Deol, Harnimarta,Singh, Gurpreet,Kumar, Manoj,Bhalla, Vandana
supporting information, p. 822 - 826 (2018/02/06)
A supramolecular polymer of PBI derivative and ZnO NPs has been developed which exhibits remarkable efficiency in direct dehydrogenative cross-coupling between terminal alkynes and aldehydes for the synthesis of ynones under photocatalytic conditions.
Asymmetric synthesis of new β-lactam lipopeptides as bacterial signal peptidase i inhibitors
Crauste, Celine,Froeyen, Matheus,Anne, Jozef,Herdewijn, Piet
, p. 3437 - 3449 (2011/09/12)
The transmembrane bacterial enzyme, signal peptidase I, is recognized as being a promising target for reducing the emergence of drug resistance. The asymmetric synthesis and the biological evaluation of original β-lactam lipopeptides have been performed t
Contrasting fates for 6-α-methylpenicillin N upon oxidation by deacetoxycephalosporin C synthase (DAOCS) and deacetoxy/deacetylcephalosporin C synthase (DAOC/DACS)
Hamilton, Christopher S.,Yasuhara, Akito,Baldwin, Jack E.,Lloyd, Matthew D.,Rutledge, Peter J.
, p. 2511 - 2514 (2007/10/03)
6-α-Methylpenicillin N was synthesised via known routes from 6-aminopenicillanic acid, and tested as a substrate for recombinant DAOCS and DAOC/DACS. Incubation with DAOCS resulted in conversion of 2-oxoglutarate without oxidation of the penicillin substrate ('uncoupled turnover'). Incubation with DAOC/DACS resulted in oxidation to the cephem aldehyde. This is the first example of substrate-induced 'uncoupled turnover', which has been proposed to be an editing mechanism for these enzymes. Elsevier Science Ltd. All rights reserved.