364-22-7

Basic information

• Product Name: 2-Fluoronicotinamide
• Synonyms: 2-fluoropyridine-3-carboxamide;2-fluoro-nicotinic acid aMide;2-Fluoronicotinamide
• CAS NO: 364-22-7
• Molecular Formula: C₆H₅FN₂O
• Molecular Weight: 140.12
• Product Categories: Pyridines
• Mol File: 364-22-7.mol

Chemical Properties

• Melting Point: 120.9-122 °C
• Boiling Point: 287.9°Cat760mmHg
• Flash Point: 127.9°C
• Appearance: /
• Density: 1.327g/cm³
• Vapor Pressure: 0.00242mmHg at 25°C
• Refractive Index: 1.542
• Storage Temp.: 2-8°C
• PKA: 14.10±0.50(Predicted)
• CAS DataBase Reference: 2-Fluoronicotinamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Fluoronicotinamide(364-22-7)
• EPA Substance Registry System: 2-Fluoronicotinamide(364-22-7)

Safety Data

• Hazardous Substances Data: 364-22-7(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
2-Fluoronicotinamide is used as an intermediate in the production of pharmaceuticals for its potential applications in the development of new drugs. It contributes to the synthesis of compounds with therapeutic properties, enhancing the range of available treatments.
Used in Agrochemical Industry:
2-Fluoronicotinamide is utilized as a precursor in the synthesis of agrochemicals, specifically for the development of new pesticides or other agricultural chemicals. Its incorporation aids in creating more effective and targeted products for crop protection and enhancement of agricultural yields.
Used in Research and Development:
2-Fluoronicotinamide serves as a key building block in the research and development of novel compounds with potential applications in medicine and agriculture. Its unique structure allows scientists to explore new avenues for drug discovery and the improvement of existing therapeutic agents.
Used as an Anti-Inflammatory Agent:
2-Fluoronicotinamide is studied for its potential as an anti-inflammatory agent, which could be beneficial in treating various inflammatory conditions. Its properties may contribute to the modulation of inflammatory responses, providing a new approach to managing inflammation-related disorders.
Used as a Neuroprotective Agent:
2-Fluoronicotinamide has been investigated for its neuroprotective potential, making it a candidate for the development of treatments aimed at preserving or improving neuronal function in neurodegenerative diseases. Its protective effects on neurons could lead to advancements in the management of such conditions.

InChI:InChI=1/C6H5FN2O/c7-5-4(6(8)10)2-1-3-9-5/h1-3H,(H2,8,10)

Upstream product

• 119899-26-2 2-fluoronicotinic acid chloride 
• 2369-18-8 2-fluoro-3-methylpyridine 
• 1603-40-3 3-methylpyridin-2-ylamine 
• 393-55-5 2-fluoronicotinic acid 
• 5345-47-1 2-aminopyridin-3-carboxylic acid 
• 446-26-4 methyl 2-fluoro-3-pyridinecarboxylate 

Downstream Products

• 10128-92-4 2-hydroxynicotinamide 
• 609-71-2 2-hydroxy-3-carboxypyridine 
• 3939-13-7 3-cyano-2-fluoropyridine 

Relevant articles and documents

CB1 MODULATOR COMPOUNDS

Novel compounds of structural formula (I) are disclosed. As modulators of the Cannabinoid-1 (CB1) receptor, these compounds are useful in the treatment, prevention and suppression of diseases mediated by the CB1 receptor. As such, compounds of the present invention are useful as in the treatment, prevention and suppression of psychosis, memory deficits, cognitive disorders, migraine, neuropathy, neuro-inflammatory disorders (e.g., multiple sclerosis, Guillain-Barre syndrome and the inflammatory sequelae of viral encephalitis), cerebral vascular accidents, head trauma, anxiety disorders, stress, epilepsy, Parkinson's disease, and schizophrenia. The compounds are also useful for the treatment of substance abuse disorders, particularly to opiates, alcohol, and nicotine. The compounds are also useful for the treatment of obesity or eating disorders associated with excessive food intake and complications associated therewith.