364362-49-2

Basic information

• Product Name: N-methyl-N-phenyl-1-naphthalenesulfonamide
• Synonyms: N-methyl-N-phenyl-1-naphthalenesulfonamide
• CAS NO: 364362-49-2
• Molecular Formula: C₁₇H₁₅NO₂S
• Molecular Weight: 297.3715
• Mol File: 364362-49-2.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: N-methyl-N-phenyl-1-naphthalenesulfonamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-methyl-N-phenyl-1-naphthalenesulfonamide(364362-49-2)
• EPA Substance Registry System: N-methyl-N-phenyl-1-naphthalenesulfonamide(364362-49-2)

Safety Data

• Hazardous Substances Data: 364362-49-2(Hazardous Substances Data)

Upstream product

• 85-46-1 1-Naphthalenesulfonyl chloride 
• 121-69-7 N,N-dimethyl-aniline 
• 7647-01-0 hydrogenchloride 
• 16358-37-5 N-methyl-N-phenylnaphthalene-2-sulfonamide 

Downstream Products

• 479-45-8 tetryl 
• 91-20-3 naphthalene 
• 74-87-3 methylene chloride 
• 7664-93-9 sulfuric acid 
• 62-53-3 aniline 
• 529-36-2 1-Naphthalenethiol 

Relevant articles and documents

Synthetic use of 1,1,2,2-tetraphenyldisilane for the preparation of biaryls through the intramolecular free radical ipso-substitution of N-(2-bromoaryl)arenesulfonamides

Treatment of various N-methyl-N-(2-bromoaryl)arenesulfonamides (1a-g, 1i, and 1m) with 1,1,2,2-tetraphenyldisilane and AIBN under heating conditions gave the corresponding biaryl products (2a-g, 2i, and 2m) in moderate yields through the intramolecular radical ipso-substitution. However, N-H free N-(2-bromoaryl)arenesulfonamides 1h and 2-bromoaryl arenesulfonate 1j did not give the corresponding biarys. 1,1,2,2-Tetraphenyldisilane is the most effective reagent for 1,5-ipso-substitution on the sulfonamides among typical radical reagents such as diphenylsilane, tributyltin hydride, tris(trimethylsilyl)silane, and 1,1,2,2-tetraphenyldisilane. Furthermore, 1,1,2,2-tetraphenyldisilane has the advantages of low toxicity, stability, and ease of preparation.