3649-46-5Relevant articles and documents
Hydrogenation reaction method
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Paragraph 0034; 0224-0228, (2020/05/14)
The invention relates to a hydrogenation reaction method, and belongs to the technical field of organic synthesis. The hydrogenation reaction method provided by the invention comprises the following steps: carrying out a hydrogen transfer reaction on a hydrogen acceptor compound, pinacol borane and a catalyst in a solvent in the presence of proton hydrogen, so that the hydrogen acceptor compound is subjected to a hydrogenation reaction; the catalyst is one or more than two of a palladium catalyst, an iridium catalyst and a rhodium catalyst; the hydrogen acceptor compound comprises one or morethan two functional groups of carbon-carbon double bonds, carbon-carbon triple bonds, carbon-oxygen double bonds, carbon-nitrogen double bonds, nitrogen-nitrogen double bonds, nitryl, carbon-nitrogentriple bonds and epoxy. The method is mild in reaction condition, easy to operate, high in yield, short in reaction time, wide in substrate application range, suitable for carbon-carbon double bonds,carbon-carbon triple bonds, carbon-oxygen double bonds, carbon-nitrogen double bonds, nitrogen-nitrogen double bonds, nitryl, carbon-nitrogen triple bonds and epoxy functional groups, good in selectivity and high in reaction specificity.
Visible Light as a Sole Requirement for Intramolecular C(sp3)-H Imination
Li, Jingjing,Zhang, Pengxiang,Jiang, Min,Yang, Haijun,Zhao, Yufen,Fu, Hua
, p. 1994 - 1997 (2017/04/28)
A novel, simple, and practical visible-light-mediated intramolecular α-C(sp3)-H imination of tertiary aliphatic amines containing β-O-aryl oximes leading to N-heterocycles has been developed. The reaction was performed well at rt with tolerance of some functional groups. Importantly, the selective C-H functionalization did not require added catalyst, oxidant, additive, acid, and base; visible light was the sole requirement.
Reduction method of nitrogen-containing heterocyclic compound
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Paragraph 0035; 0036; 0037; 0038, (2017/02/09)
The invention discloses a reduction method of a nitrogen-containing heterocyclic compound. The reduction method comprises the following steps: firstly, adding bis(pinacolato)diboron, palladium acetate and cesium carbonate into a pressure-resisting sealing reaction vessel; filling with nitrogen, adding water and quinoline compounds, performing stirring reaction at room temperature, and tracking by using TLC and GC in a reaction process so as to decide specific reaction time; secondly, after the reaction is ended, taking out a reaction product in the first step from the pressure-resisting sealing reaction vessel, cooling to room temperature, then adding ethyl acetate for fully mixing, and subsequently performing filtering and washing of ethyl acetate to obtain an organic phase; thirdly, performing spin drying on a solvent in the organic phase obtained in the second step, purifying by using a silica gel column, and then leaching with an eluant to obtain a product. The eluant is a mixed solution of petroleum ether and the ethyl acetate. The reduction method disclosed by the invention accords with the idea of green chemistry, and is better in economy and simple in operation.
