41208-54-2

Upstream product

• 41208-22-4 1-(2-Amino-2-phenyl-ethyl)piperidin 
• 7101-04-4 (E/Z)-1-(2-hydroximino-2-phenylethyl)piperidine 
• 41208-34-8 1-(2-Acetylamino-2-phenyl-ethyl)piperidin 

Downstream Products

• 41208-22-4 1-(2-Amino-2-phenyl-ethyl)piperidin 
• 41208-66-6 2-phenyl-perhydroimidazo[1,2-a]pyridine 
• 99258-42-1 2,3,5,6,7,8-Hexahydro-2-phenyl-8-p-methoxybenzylthioimidazo[1,2-a]pyridine fumarate 
• 99258-48-7 2,3,5,6,7,8-Hexahydro-2-phenyl-8-ipropylthioimidazo[1,2-a]pyridine sulfate 
• 99258-38-5 2,3,5,6,7,8-Hexahydro-2-phenyl-8-p-chlorophenylthioimidazo[1,2-a]pyridine sulfate 
• 3649-46-5 2-Phenyl-5,6,7,8-tetrahydro-imidazo<1,2-a>pyridin 

Relevant academic research and scientific papers

Dehydrogenation of cyclic tertiary amines with neighbouring of enantiomeric nucleophiles

For stereochemical investigation of their dehydrogenation, the enantiomers of the aminoalcohols 1, 2, and 3 were prepared from optically active sources, while the enantiomers of the diamines 8 and 9 were available by resolution of the racemates. The pure antipodes of 1, 2, and 3 reacted with mercury(II)-EDTA by a twofold dehydrogenation via intermediate participation of the neighbouring alcoholic group to the optically active lactams 5, 6, and 7 under complete retention of configuration. In the same manner the diamines 8 and 9 generated by four electron withdrawal the cycloamidines 10 and 11.

Neighbour Group Participation with Reductions and Hydride Abstractions - Part 2

The reduction of N-(2-aminoalkyl)lactams with diisobutylaluminium hydride and the hydride ion abstraction of the corresponding diamines give under neighbour group participation the fused aminals.