3651-67-0

Usage

Chemical Properties

white to pale yellow hygroscopic powder

InChI:InChI=1/C5H11NO.ClH/c1-6-2-4-7-5-3-6;/h2-5H2,1H3;1H

Upstream product

• 91681-56-0 (3R)-3-dodecanoyloxytetradecanoic acid 
• 543-27-1 isobutyl chloroformate 
• 6066-82-6 1-hydroxy-pyrrolidine-2,5-dione 
• 27486-87-9 N-acetyl-S-trityl-L-cysteine 
• 109-02-4 4-methyl-morpholine 
• 3140-73-6 2-chloro-4,6-dimethoxy-1 ,3,5-triazine 
• 158722-22-6 (4S,5R)-2,4-diphenyl-4,5-dihydrooxazole-5-carboxylic acid 
• 110-91-8 morpholine 
• 50-00-0 formaldehyd 
• 32159-21-0 Cbz-L-pGlu-OH 
• 3398-70-7 (2R,4'R,8'R)-α-tocopheramine 
• 4345-03-3 vitamin E succinate 
• 98-79-3 L-Pyroglutamic acid 
• 186581-53-3 diazomethane 

Downstream Products

• 3074-43-9 1-methyl-4-phenylpiperazine 
• 15648-16-5 4-methylmorpholine - borane (1/1) 
• 109-01-3 1-methyl-piperazine 

Relevant academic research and scientific papers

Reductive Alkylation of Amines with Carboxylic Ortho Esters

We have demonstrated for the first time that carboxylic ortho esters could be used as an alkylating agent in the reductive alkylation of amines. A variety of amines, including amino acid esters, were alkylated affording mono-alkylated products with high selectivity in practical to high yields using standard heterogeneous catalysts. By applying acyclic ortho esters alkylation was completed at room temperature. (Figure presented.).

N -Monomethylation of amines using paraformaldehyde and H2

The selective N-monomethylation of amines is an important topic in fine chemical synthesis. Herein, for the first time, we described a selective N-monomethylation reaction of amines with paraformaldehyde and H2 in the presence of a CuAlOx catalyst. A variety of amines, including primary aromatic amines, benzylamine and cyclohexylamine, as well as secondary amines, have been shown to be compatible with this reaction.

Optimized triazine-mediated amidation for efficient and controlled functionalization of hyaluronic acid

Triazine-based coupling agents have the potential to replace carbodiimides in the functionalization of hyaluronic acid (HA) giving derivatives with high degrees of substitution (DS) under mild conditions with excellent efficiency. Kinetics of the triazine

A dramatic effect of the ionic liquid structure in esterification reactions in protic ionic media

Bronsted acidic ionic liquids (ILs) have been synthesized and investigated as catalysts in esterification and transesterification reactions: simple and non-corrosive salts characterized by aliphatic cations associated with an "acidic" anion (in particular, [HSO4]-) gave the higher yields. A quite good correlation between IL acidity (H 0) and catalytic ability was found although also the hydrophilic nature of the ionic medium probably affects the process efficiency.

Vitamin E conjugates

Vitamin E conjugates, methods for their preparation, and compositions that include the conjugates. The vitamin E conjugates include a tocopherol moiety covalently coupled through a linker moiety to either a pyroglutamate moiety, a pyrrolidinone moiety, or a gentisic acid moiety.

Small organic molecule regulators of cell proliferation

The present invention makes available methods and reagents for modulating proliferation or differentiation in a cell or tissue comprising contacting the cell with a hedgehog agonist, such as the compounds depicted in FIGS. 32 and 33. In certain embodiments, the methods and reagents may be employed to correct or inhibit an aberrant or unwanted growth state, e.g., by antagonizing a normal ptc pathway or agonizing smoothened or hedgehog activity.

Novel acyl-dipeptide-like compounds bearing an accessory functional side chain spacer, a method for preparing the same and pharmaceutical compositions containing such products

The present invention is directed in particular to dipeptide-like compounds derived from functionally substituted amino acids, having fatty acid chains bound thereto through amidification of the amine functional groups of said dipeptide-like compounds, one end portion of which bears an accessory functional side chain spacer, with the other end portion being an acid group either in neutral or charged state. Compounds of the present invention have immunomodulating properties like adjuvants, In addition, compounds of the invention can be grafted on a given antigen in order to modulate or tune the immune response or can be equally grafted on a pharmaceutical carrier to enhance the therapeutic effect or targetting thereof. Accordingly, compounds of the invention find use in human and veterinary medicine both as immunogens and diagnostic tools.

THE METHOD FOR PRODUCTION OF SEMI-FINISHED PRODUCTS USEFUL IN SYNTHESIS OF PACLITAXEL

The method for production of the semi-finished products useful in synthesis of Paclitaxel with the generalized formula (2), characterized in that phenyl isoserine derivatives, or mixtures of their epimerides with various configurations on the carbon 2' or their salts, are treated with triazine type condensing agent, possible in the presence of tertiary amine, in medium of anhydrous organic solvent, and the triazine esters produced are treated with Baccatin III, in medium of anhydrous organic solvent, possible in the presence of a catalyst.

Novel antioxidants, preparation processes and their uses

The invention concerns a process for preparing compounds of general formula (I) wherein R and R′ represent an alkyl radical or an aryl group; and R″ is hydrogen or a CO—R1 group wherein R1 is an alkyl radical or an aryl group; and wherein these compounds are or not in the thiazolidine form; by protecting the N-acyl-L-cysteine to form an intermediate compound; and then by coupling said intermediate compound with S-acylcysteamine hydrochloride or with thiazolidine.

Small organic molecule regulators of cell proliferation

A compound represented in general formula (X) and (XI):