17467-60-6Relevant academic research and scientific papers
H2O2-Mediated Synthesis of 1,2,4-Thiadiazole Derivatives in Ethanol at Room Temperature
Cao, Xian-Ting,Zheng, Zuo-Ling,Liu, Jie,Hu, Yu-He,Yu, Hao-Yun,Cai, Shasha,Wang, Guannan
, p. 689 - 694 (2022/01/11)
Herein, we report the H2O2-mediated synthesis of 1,2,4-thiadiazole derivatives under metal-free conditions at room temperature with ethanol as the sole solvent. Various substrates could undergo the reaction smoothly, providing the ex
Transition-metal-free visible Light-promoted photoredox oxidative dehydrogenative cyclization:expeditious approach to 1,2,4-thiadiazoles
Chen, Junmin,Sheng, Shouri,Xiong, Zhiqiang,Zhong, Qihao
, (2021/09/06)
A novel visible-light-catalyzed oxidative N-S bond formation for the synthesis of 3,5-disubstituted 1,2,4-thiadiazoles has been developed. This protocol features a metal-free approach, green oxidant, room temperature process, broad substrate scope, good functional group tolerance, excellent yields and a one-pot reaction without the isolation of the intermediates.
Catalyst-free, one-pot strategy to access 3-substituted-5-amino-1,2,4-thiadiazoles in water
Nagaraju, Chaithra,Ashok, Swarup Hassan,Narayana, Yatheesh,Nagarakere, Sandhya C.,Kempegowda, Mantelingu,Kanchugarkoppal, Rangappa S.
, p. 3610 - 3619 (2021/10/14)
A protocol has been devised for the synthesis of 3-substituted 5-amino-1,2,4-thiadiazoles utilizing isothiocyanates, amidoximes and water as an eco-friendly solvent. The strategy involves consecutive C?N and S?N bonds formation in a one-pot reaction under
Electrochemical Synthesis of 1,2,4-Thiadiazoles through Intermolecular Dehydrogenative S-N Coupling
Li, Jiang-Sheng,Xie, Xin-Yun,Yang, Pan-Pan,Jiang, Si,Tao, Li,Li, Zhi-Wei,Lu, Cui-Hong,Liu, Wei-Dong
supporting information, p. 771 - 775 (2019/12/12)
An electrochemical intermolecular dehydrogenative coupling reaction of isothiocyanates with 2-aminopyridines/amidines was developed. Using n-Bu4NI as the catalyst and electrolyte, 1,2,4-thiadiazoles and pyrido-fused 1,2,4-thiadiazoles were readily accessed with good to excellent efficiency under the undivided electrolysis conditions. This electrochemical approach obviates the use of external oxidants and transition-metal catalysts. (Figure presented.).
External oxidant-free electrooxidative intramolecular S-N bond formation for one-pot synthesis for 3,5-disubstituted 1,2,4-thiadiazoles
Zhong, Qihao,Sheng, Shouri,Chen, Junmin
, p. 988 - 993 (2020/07/04)
An electrochemical oxidative reaction protocol for the synthesis of 5-amino and 3,5-diamino substituted 1,2,4-thiadiazole derivatives has been developed under undivided electrolytic conditions. The newly developed one-pot methodology involves the reaction
Electrochemical Oxidative Intramolecular N-S Bond Formation: Synthesis of 3-Substituted 5-Amino-1,2,4-Thiadiazoles
Yang, Zan,Zhang, Jiaqi,Hu, Liping,Li, Lijun,Liu, Kun,Yang, Tao,Zhou, Congshan
, p. 3358 - 3363 (2020/03/23)
A facile and efficient protocol for the synthesis of 3-substituted 5-amino-1,2,4-thiadiazoles has been developed through the electro-oxidative intramolecular dehydrogenative N-S bond formation of imidoyl thioureas. Various 1,2,4-thiadiazole derivatives we
Transition-metal-free S-N bond formation: Synthesis of 5-amino-1,2,4-thiadiazoles from isothiocyanates and amidines
Yang, Zan,Cao, Ting,Liu, Si,Li, An,Liu, Kun,Yang, Tao,Zhou, Congshan
supporting information, p. 6465 - 6468 (2019/05/06)
A novel and green method for the synthesis of 5-amino-1,2,4-thiadiazoles has been developed by the reaction of isothiocyanates with amidines. This protocol which is free of metal, catalyst and iodine involves O2 oxidative S-N bond formation for
Co-Catalyzed Intramolecular S-N Bond Formation in Water for 1,2-Benzisothiazol-3(2H)-ones and 1,2,4-Thiadiazoles Synthesis
Yang, Liting,Song, Lijuan,Tang, Shanyu,Li, Longjia,Li, Heng,Yuan, Bingxin,Yang, Guanyu
, p. 1281 - 1285 (2019/01/14)
An efficient and versatile Co-catalyzed intramolecular S-N bond formation in water to synthesize 1,2-benzisothiazol-3(2H)-one and 1,2,4-thiadiazoles derivatives in good to excellent yields was developed. The transformation showed great tolerance with a broad range of substituents. The mother liquor was able to be recycled 6 times with minor loss in product yield.
Regioselective C-C cross-coupling of 1,2,4-thiadiazoles with maleimides through iridium-catalyzed C-H activation
Tian, Ting,Dong, An-Shun,Chen, Dan,Cao, Xian-Ting,Wang, Guannan
supporting information, p. 7664 - 7668 (2019/08/30)
A regioselective C-C cross-coupling of 1,2,4-thiadiazoles with maleimides through iridium catalysis was developed. This transformation tactically linked the 1,2,4-thiadiazoles and succinimides together, and the novel molecules formed may have potential biological activity.
Copper-Catalyzed Aerobic Oxidative [3+2] Annulation for the Synthesis of 5-Amino/Imino-Substituted 1,2,4-Thiadiazoles through C-N/N-S Bond Formation
Yu, Wentao,Huang, Yubing,Li, Jianxiao,Tang, Xiaodong,Wu, Wanqing,Jiang, Huanfeng
, p. 9334 - 9343 (2018/07/30)
A copper-catalyzed aerobic oxidative annulation reaction of 2-aminopyridine/amidine with isothiocyanate has been reported. This strategy involving C-N/N-S bond formations provides various 5-amino/imino-substituted 1,2,4-thiadiazole derivatives under a Cu/O2 catalytic system. This method has demonstrated high reactivity, mild reaction conditions, and a broad substrate scope. Furthermore, the synthetic utilities of the approach are demonstrated by further modifications.
