36701-89-0

Basic information

• Product Name: 2-[3-(TRIFLUOROMETHYL)PHENOXY]NICOTINIC ACID
• Synonyms: 2-[3-(TRIFLUOROMETHYL)PHENOXY]NICOTINIC ACID;2-(3-(trifluoromethyl)phenoxy)-3-pyridinecarboxylicaci;2-(3-(trifluoromethyl)phenoxy)-3-pyridinecarboxylicacid;2-[3-(trifluoroMethyl)phenoxy]nicotiric acid;2-[3-(Trifluoromethyl)phenoxy]pyridine-3-carboxylic acid, 3-[(3-Carboxypyridin-2-yl)oxy]benzotrifluoride
• CAS NO: 36701-89-0
• Molecular Formula: C₁₃H₈F₃NO₃
• Molecular Weight: 283.2
• Mol File: 36701-89-0.mol
• Article Data: 7

Chemical Properties

• Melting Point: 156-159°C
• Boiling Point: 366°Cat760mmHg
• Flash Point: 175.2°C
• Appearance: /
• Density: 1.421g/cm³
• Vapor Pressure: 5.31E-06mmHg at 25°C
• Refractive Index: 1.541
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility: DMSO (Slightly), Methanol (Slightly)
• CAS DataBase Reference: 2-[3-(TRIFLUOROMETHYL)PHENOXY]NICOTINIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 2-[3-(TRIFLUOROMETHYL)PHENOXY]NICOTINIC ACID(36701-89-0)
• EPA Substance Registry System: 2-[3-(TRIFLUOROMETHYL)PHENOXY]NICOTINIC ACID(36701-89-0)

Safety Data

• Hazard Codes: Xi
• Statements: 43
• Safety Statements: 36/37
• HazardClass: IRRITANT
• Hazardous Substances Data: 36701-89-0(Hazardous Substances Data)

Usage

Uses

2-[3-(Trifluoromethyl)phenoxy]nicotinic Acid (cas# 36701-89-0) is a useful reagent for the preparation of difluoroalkylarenes via photocatalytic alkylation of trifluoromethylarenes with alkenes.

InChI:InChI=1/C13H8F3NO3/c14-13(15,16)8-3-1-4-9(7-8)20-11-10(12(18)19)5-2-6-17-11/h1-7H,(H,18,19)

Upstream product

• 2942-59-8 2-chloronicotinic acid 
• 98-17-9 3-Trifluoromethylphenol 
• 59-67-6 nicotinic acid 
• 1570135-74-8 N-(2-(4,5-dihydrooxazol-2-yl)phenyl)nicotinamide 
• 72332-16-2 m-TFO^(1-) 
• 83164-33-4 N-(2,4-difluorophenyl)-2-(3-trifluoromethylphenoxy)-3-pyridinecarboxamide 

Downstream Products

• 1224638-09-8 (3,4-dihydro-2H-quinolin-1-yl)-[2-(3-trifluoromethyl-phenoxy)-pyridin-3-yl]-methanone 
• 40688-79-7 2-(3-trifluoromethylphenoxy)-3-pyridinecarboxylic acid chloride 
• 83164-33-4 N-(2,4-difluorophenyl)-2-(3-trifluoromethylphenoxy)-3-pyridinecarboxamide 
• 214756-71-5 N-[4-(1-Hydroxy-1-methyl-ethyl)-benzyl]-2-(3-trifluoromethyl-phenoxy)-nicotinamide 

Relevant articles and documents

Novel 2－ aryloxynicotinamide compound as well as preparation method and application thereof

The invention relates to a novel 2 - aryloxynicotinamide compound as well as a preparation method and application. of the 2 - aryloxynicotinamide compound as shown in the following formula (I). The compound can be used for preparing,aryloxy nicotinic acid compounds and derivatives thereof through a condensation reaction and a carbon hydrogen bond direct etherification method as shown in the formula shown in the specification. The invention relates to a novel method for preparing. 2 - aryloxynicotinic acid compounds and, derivatives thereof as shown in the structural formula shown. in the structural formula shown in the following formula. In Formula (I), the steric configuration of the carbon atom attached to the substituent R is R or S,Ar, and the aromatic substituent (is shown in more detail in the specification).

NOVEL PHENYL AMIDE OR PYRIDYL AMIDE DERIVATIVES

This invention relates to novel phenyl amide or pyridyl amide derivatives of the formula wherein A1, A2, B1, B2 and R1 to R11 are as defined in the description and in the claims, as well as pharmaceutically acceptable salts thereof. These compounds are GPBAR1 agonists and can be used as medicaments for the treatment of diseases such as type II diabetes.

Nicotinamide Ethers: Novel Inhibitors of Calcium-Independent Phosphodiesterase and Rolipram Binding

The synthesis and biological properties of a series of nicotinamide ethers are described.These compounds, structurally novel calcium-independent phosphodiesterase inhibitors, also inhibit the binding of rolipram to rat brain membranes and reverse rese