36729-28-9

Usage

Uses

Used in Pharmaceutical Industry:
2,3-diphenyl-1H-indole-5-carboxylic acid is used as a precursor or intermediate for the synthesis of pharmaceuticals and other organic compounds. Its unique structure and properties make it a valuable component in the development of new drugs, contributing to the advancement of medicinal chemistry.
Used in Drug Development:
2,3-diphenyl-1H-indole-5-carboxylic acid is used as a key component in the formulation of new drugs. Its potential role in the synthesis of pharmaceuticals allows for the exploration of its therapeutic applications, which could lead to the discovery of novel treatments for various diseases and conditions.

Upstream product

• 451-40-1 phenyl benzyl ketone 
• 619-67-0 4-Hydrazinobenzoic acid 
• 24589-77-3 4-hydrazinobenzoic acid hydrochloride 
• 501-65-5 diphenyl acetylene 
• 150-13-0 4-amino-benzoic acid 

Downstream Products

• 36729-31-4 2,3-diphenyl-indole-5-carboxylic acid ethyl ester 
• 61566-69-6 4-amino-3-benzoyl-benzoic acid 

Relevant academic research and scientific papers

URAZOLE COMPOUNDS

The present invention relates to a compound of formula (I) or a stereoisomer, enantiomer, racemic, or tautomer thereof, (I) wherein R1, R2, R3, R4, R5, R6, R7, L1 and Q1 have the meaning defined in the claims and the description. The present invention also relates to a process for the preparation of the compound of formula (I). The present invention also relates to the use of a compound of formula (I) as an in situ precursor of a triazolinedione reagent for the functionalization of enes, dienes, aryl and heteroaryl systems via the ene reactions, Diels-Alder reactions, and electrophilic aromatic substitution reactions of said reagent. The present invention also relates to the use of a compound of formula (I) in polymers, membranes, adhesives, foams, sealants, molded articles, films, extruded articles, fibers, elastomers, polymer based additives, pharmaceutical and biomedical products, varnishes, paints, coatings, inks, composite material, organic LEDs, organic semiconductors, conducting organic polymers, or 3D printed articles. The present invention also relates to article comprising said compound of formula (I) and to a process for reshaping and/or repairing said article.

Regioselective synthesis of indoles via rhodium-catalyzed C-H activation directed by an in-situ generated redox-neutral group

A regioselective synthesis of indoles from arylhydrazine hydrochlorides with alkynes and diethyl ketone catalyzed by a rhodium complex is described. A possible mechanism involving an in-situ generated oxidizing directing group -N-Ni'CR1R2 assisted ortho-C-H activation and reductive elimination are proposed. The catalytic reaction is highly compatible with a wide range of functional arylhydrazines and alkynes. The reaction proceeds under mild reaction conditions and is atom-step economical.

AZAINDOLE DERIVATIVES

Compounds of the formula (I), in which X1, X2, X3, X4, R1, R2, R3 and R4 have the meanings indicated in Claim 1, are inhibitors of tyrosine kinases, in particular Met

Substituted indoles

Compounds of the formula I are suitable for preparing pharmaceuticals for the prophylaxis and therapy of disorders in whose course an increased activity of NFκB is involved.