3673-38-9

Basic information

• Product Name: ethyl carbamothioylcarbamate
• CAS NO: 3673-38-9
• Molecular Formula: C₄H₈N₂O₂S
• Molecular Weight: 148.1835
• Mol File: 3673-38-9.mol
• Article Data: 2

Chemical Properties

• Density: 1.282g/cm³
• Refractive Index: 1.549
• CAS DataBase Reference: ethyl carbamothioylcarbamate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl carbamothioylcarbamate(3673-38-9)
• EPA Substance Registry System: ethyl carbamothioylcarbamate(3673-38-9)

Safety Data

• Hazardous Substances Data: 3673-38-9(Hazardous Substances Data)

Upstream product

• 16182-04-0 Ethoxycarbonyl isothiocyanate 
• 7664-41-7 ammonia 
• 89164-67-0 N,N'-bis-ethoxycarbonyl-thiourea 
• 1263166-90-0 (1R,8S,9S)‐bicyclo[6.1.0]non‐4‐yn‐9‐ylmethanol 
• 7647-01-0 hydrogenchloride 
• 64-17-5 ethanol 
• 4755-77-5 Ethyl oxalyl chloride 
• 17356-08-0 thiourea 

Downstream Products

• 3673-34-5 thiazole-2-ylcarbamic acid ethyl ester 
• 1037088-41-7 methyl (2S)-2-({[1-(diphenylmethyl)-2-oxo-1,2-dihydropyridin-3-yl]carbonyl}amino)-4-{[(ethoxycarbonyl)carbamothioyl]amino}butanoate 
• 51863-08-2 N-Ethoxycarbonyl-S-benzylisothioharnstoff 
• 626-36-8 ethyl allophanate 
• 603-54-3 N,N-diphenylurea 

Relevant articles and documents

Design and Synthesis of Iminosydnones for Fast Click and Release Reactions with Cycloalkynes

Emerging applications in the field of chemical biology are currently limited by the lack of bioorthogonal reactions allowing both removal and linkage of chemical entities on complex biomolecules. We recently discovered a novel reaction between iminosydnones and strained alkynes leading to two products resulting from ligation and fragmentation of iminosydnones under physiological conditions. We now report the synthesis of a panel of substituted iminosydnones and the structure reactivity relationship between these compounds and strained alkyne partners. This study identified the most relevant substituents, which allow to increase the rate of the transformation and to develop a bifunctional cleavable linker with improved kinetics.