3674-10-0

Basic information

• Product Name: 1-chloro-1-phenylpropan-2-one
• Synonyms: 1-Chloro-1-phenyl-propan-2-one; 2-propanone, 1-chloro-1-phenyl-
• CAS NO: 3674-10-0
• Molecular Formula: C₅H₈Cl₂O₂
• Molecular Weight: 168.6202
• Mol File: 3674-10-0.mol

Chemical Properties

• Boiling Point: 228.1°C at 760 mmHg
• Flash Point: 112.8°C
• Density: 1.139g/cm³
• Vapor Pressure: 0.0747mmHg at 25°C
• Refractive Index: 1.524
• CAS DataBase Reference: 1-chloro-1-phenylpropan-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1-chloro-1-phenylpropan-2-one(3674-10-0)
• EPA Substance Registry System: 1-chloro-1-phenylpropan-2-one(3674-10-0)

Safety Data

• Hazardous Substances Data: 3674-10-0(Hazardous Substances Data)

Usage

Physical state

Pale yellow liquid

Odor

Pungent

Uses

a. Production of pharmaceuticals
b. Production of pesticides
c. Production of fragrances
d. Versatile intermediate in organic synthesis
e. Manufacture of other chemicals

Hazardous nature

Yes, should be handled with care and in compliance with safety regulations

Upstream product

• 102-76-1 triacetylglycerol 
• 56-81-5 glycerol 
• 64-19-7 acetic acid 
• 75-36-5 acetyl chloride 
• 106-89-8 epichlorohydrin 

Downstream Products

• 75-36-5 acetyl chloride 
• 106-89-8 epichlorohydrin 
• 96-23-1 1,3-Dichloro-2-propanol 
• 591-87-7 Allyl acetate 

Relevant articles and documents

CONVERSION OF A MULTIHYDROXYLATED-ALIPHATIC HYDROCARBON OR ESTER THEREOF TO A CHLOROHYDRIN

The present invention relates to a process for converting a multihydroxylated-aliphatic hydrocarbon or ester thereof to a chlorohydrin, by contacting the multihydroxylated-aliphatic hydrocarbon or ester thereof starting material with a source of a superatmospheric partial pressure of hydrogen chloride for a sufficient time and at a sufficient temperature, and wherein such contracting step is carried out without substantial removal of water, to produce the desired chlorohydrin product; wherein the desired product or products can be made in high yield without substantial formation of undesired overchlorinated byproducts. In addition, certain catalysts of the present invention may be used in the present process at superatmospheric, atmospheric and subatmospheric pressure conditions with improved results.

Cobalt(II)chloride catalysed cleavage of ethers with acyl halides: Scope and mechanism

Cobalt(II) chloride in acetonitrile catalyses the cleavage of a wide variety of ethers with acyl halides under mild conditions to give the corresponding esters in good yields. Acyclic aliphatic ethers are cleaved to the corresponding ester and chlorides whereas the cyclic aliphatic ethers give rise to the ω-chloroesters. The benzyl ethers can be converted to the corresponding esters along with the formation of benzyl chloride and benzyl acetamide. A comparative study for the cleavage of allyl and benzyl ether has revealed that benzyl ether can be selectively cleaved in presence of the allyl ethers. The oxiranes can be cleaved in highly regioselective manner to the corresponding-β-chloroesters. The vinyl ethers undergo sp2-hybridised carbon-oxygen bond cleavage under these conditions. Based on product analysis, a mechanism involving electron transfer followed by O-acylation and S(N)1 or S(N)2 attack by chloride-ion is discussed.